scholarly journals Efficacy of 2-hour post glucose insulin levels in predicting insulin resistance in polycystic ovarian syndrome with infertility

2011 ◽  
Vol 4 (1) ◽  
pp. 20 ◽  
Author(s):  
Pikee Saxena ◽  
Anupam Prakash ◽  
Aruna Nigam
Keyword(s):  
Insulin Resistance ◽  
Polycystic Ovarian Syndrome ◽  
Insulin Levels ◽  
Ovarian Syndrome

scholarly journals Correlation of Ovarian and Stromal Volumes to Fasting and Postprandial Insulin Levels in Polycystic Ovarian Syndrome Patients

2014 ◽  
Vol 5 (1) ◽  
pp. 12-14
Author(s):  
CB Nagori
Keyword(s):  
Insulin Resistance ◽  
Polycystic Ovarian Syndrome ◽  
Pearson Correlation ◽  
3D Ultrasound ◽  
Fasting Insulin ◽  
Ovarian Volume ◽  
Significance Level ◽  
Insulin Levels ◽  
Ovarian Syndrome ◽  
Postprandial Insulin

ABSTRACT Background Patients with polycystic ovarian syndrome (PCOS) are believed to have large ovaries due to increased stroma. They also have derangement in luteinizing hormone (LH) and testosterone levels and high insulin resistance. As insulin resistance is thought to be associated with androgen and stromal excess, correlation was expected between insulin resistance and stromal excess. Aim To assess if ovarian and stromal volumes in PCOS patients have any correlation with fasting and postprandial insulin levels. Materials and methods A prospective study of 153 subfertile patients was done over a period 18 months. After detailed history, clinical examination and informed consent of all patients were scanned by two-dimensional (2D) on day 3 of the cycle. Patients were divided into PCOS and non-PCOS groups according to Rotterdam criteria. Patients with hormonal derangements other than PCOS were excluded from the study. Patients were assessed by three-dimensional (3D) ultrasound (US) for ovarian and stromal volumes and fasting and postprandial insulin levels were checked on the same day. Results With Pearson correlation significance level of 0.354 (2 tailed) correlation for ovarian volume to fasting insulin was 0.588, for ovarian volume to postprandial insulin was 0.523, for stromal volume to fasting insulin was 0.601, and for stromal volume to postprandial insulin was 0.523. No correlation could be established in non-PCOS group. Conclusion In PCOS patients, a strong correlation was found between ovarian and stromal volume and fasting and post prandial insulin levels. How to cite this article Panchal S, Nagori CB. Correlation of Ovarian and Stromal Volumes to Fasting and Postprandial Insulin Levels in Polycystic Ovarian Syndrome Patients. Int J Infertil Fetal Med 2014;5(1):12-14.

scholarly journals To Evaluate the Association between Serum Leptin and Insulin/Insulin Resistance in Polycystic Ovarian Syndrome in a Tertiary Care Centre in North India

2019 ◽  
pp. 1-8
Author(s):  
Manohar Athrey ◽  
Manjulata Kumawat ◽  
Sameer Aggarwal
Keyword(s):  
Insulin Resistance ◽  
Polycystic Ovarian Syndrome ◽  
Tertiary Care ◽  
North India ◽  
Control Group ◽  
Care Centre ◽  
Tertiary Care Centre ◽  
Serum Leptin ◽  
Insulin Levels ◽  
Ovarian Syndrome

Background: Polycystic ovarian syndrome (PCOS) a common endocrinological disorder among women in the reproductive age group, is associated with hyperinsulinemia/Insulin resistance, obesity, menstrual irregularities and anovulation. Aim and Objectives: The present study was conducted to evaluate the association between insulin/insulin resistance and leptin among women with PCOS in a sample population of a tertiary care centre in North India. Materials: Ninety newly diagnosed cases of PCOS as per Rotterdam criteria were enrolled in the study, along with ninety normal women of similar age and BMI. Serum insulin, fasting glucose and serum leptin were estimated, Insulin resistance was calculated using (HOMA-IR) the homeostatic model for assessment-insulin resistance. Results: In our study leptin levels were raised in both cases and in controls. Leptin levels correlated positively with BMI among the cases (r=0.21) and also among the controls (r=0.003). In our study PCOS women had higher mean BMI and leptin levels when compared to controls. Insulin levels correlated positively with BMI among the cases (r=0.21) and was statistically significant (P=.004). Insulin levels were higher in women with BMI in the overweight and obese category. Although most of our cases were of lean weight and BMI in the normal range, high insulin and IR was detected in them showing impaired glucose metabolism. Leptin levels were higher in cases group who also had high IR when compared to healthy controls in our study. Leptin levels correlated positively with IR among cases (r=0.25) and this was statistically significant (P=.013). Conclusion: Our study showed higher serum Leptin, insulin and IR among PCOS cases when compared to the control group.

Polycystic ovarian syndrome: Correlation between hyperandrogenism, insulin resistance and obesity

2020 ◽  
Vol 502 ◽  
pp. 214-221 ◽  
Author(s):  
Xin Zeng ◽  
Yuan-jie Xie ◽  
Ya-ting Liu ◽  
Shuang-lian Long ◽  
Zhong-cheng Mo
Keyword(s):  
Insulin Resistance ◽  
Polycystic Ovarian Syndrome ◽  
Ovarian Syndrome

scholarly journals Role of insulin sensitising agents in altering PSA level in PCOS

2017 ◽  
Vol 6 (11) ◽  
pp. 4986 ◽  
Author(s):  
Rajashree Panigrahy ◽  
Bratati Singh ◽  
Tapan K. Pattnaik ◽  
Sanjukta Misra
Keyword(s):  
Insulin Resistance ◽  
Polycystic Ovarian Syndrome ◽  
Specific Antigen ◽  
Serum Testosterone ◽  
Healthy Controls ◽  
Androgen Excess ◽  
Control Serum ◽  
Ovarian Syndrome ◽  
Significant Concentration

Background: Ovarian androgen production can be promoted by insulin resistance which leads to reproductive abnormalities in Polycystic Ovarian Syndrome (PCOS). A wide variety of female tissues can synthesize and secrete Prostate Specific Antigen (PSA). Androgens may take part a significant role in PSA secretion in PCOS. As insulin resistance stimulates androgen production, the baseline value of PSA may decline by insulin sensitising agents in PCOS. Present study is an attempt to measure the function of PSA as a marker of androgen excess in PCOS and to assess the role of insulin sensitising agent metformin in altering PSA level in PCOS.Methods: The study was undertaken to assess the insulin resistance, testosterone and PSA level in 45 women diagnosed as PCOS and 45 healthy controls. Alteration of insulin resistance, serum testosterone and PSA levels by metformin was also analysed.Results: A significant increase in testosterone, PSA level and insulin resistance was observed in PCOS cases when compared with control (p<0.001). When metformin was given for 4 months, improvement in insulin resistance and testosterone level was found in cases, but PSA values observed no change. Correlation was not found linking insulin resistance with PSA level prior to and after therapy.Conclusions: Serum PSA level could be detected in high significant concentration in PCOS women. Various researches explain that insulin resistance and BMI may perhaps control serum PSA level, but our result demonstrate no effect of insulin sensitising agent on serum PSA value.

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