The purpose of the study is to estimate the permeability of haemocapillaries in archicortex and paleocortex at alcohol intoxication and under the influence of ionizing irradiation. The experiment was carried out on 168 mature white inbred male rats of 180-200 g by mass at the age of 2.5-3 months, which were divided into 4 groups. In the first group of animals were irradiated by g-quanta 60Co dose of 87.5 Grams; run the second group of animals 15% aqueous ethanol solution in the dose of 2.25 g/kg was introduced intraperitoneally; in the third group the radiation monitoring was held; in the fourth group the ethanol control (injection of saline in similar dose) was carried out. The alkaline phosphatase was identified by a-naphthilphosphate and strong blue PP. The results were estimated statistically. The same type of activities changes of the alkaline phosphatase have been determined experimentally in pyri-form cortex and hippocampus at early phases of postradiation period, unlike the same phases of alcohol intoxication. Both of the studied factors provoke an hour after the impact of the development of destructive changes in the structures of the blood-brain barrier. Th determined changes of blood-brain barrier permeability depends on the phylogenetic age of parts of the cortex and manifest more sig nificant in younger formations (hippocampus) than in older ones (pyriform cortex).
A novel role for tissue-nonspecific alkaline phosphatase at the blood-brain barrier during sepsis
