scholarly journals Reversible ecchymosis and hyperpigmented lesions: A rare presentation of dietary Vitamin B12 deficiency

2016 ◽  
Vol 5 (2) ◽  
pp. 485 ◽  
Author(s):  
HansRaj Pahadiya ◽  
Manoj Lakhotia ◽  
Sukhdev Choudhary ◽  
GopalRaj Prajapati ◽  
Sangeeta Pradhan
2002 ◽  
Vol 55 (6) ◽  
pp. 475-476 ◽  
Author(s):  
P O'Gorman ◽  
D Holmes ◽  
A V Ramanan ◽  
B Bose-Haider ◽  
M J Lewis ◽  
...  

2003 ◽  
Vol 49 (12) ◽  
pp. 2076-2078 ◽  
Author(s):  
Zouë Lloyd-Wright ◽  
Anne-Mette Hvas ◽  
Jan Møller ◽  
Tom A B Sanders ◽  
Ebba Nexø

2017 ◽  
Vol 85 (4) ◽  
pp. 322-324
Author(s):  
K. Jagadish Kumar ◽  
Divya Chowdary ◽  
Akshatha U. Shetty ◽  
C. Anitha

Nutrients ◽  
2022 ◽  
Vol 14 (2) ◽  
pp. 334
Author(s):  
Živa Lavriša ◽  
Hristo Hristov ◽  
Maša Hribar ◽  
Katja Žmitek ◽  
Anita Kušar ◽  
...  

Vitamin B12 deficiency poses a health concern, especially in vulnerable populations. Dietary vitamin B12 intake was obtained by two 24 h dietary recalls and food propensity questionnaires in a representative Slovenian cross-sectional food consumption survey, SI.Menu (n = 1248 subjects; 10–74 years). For a subgroup of 280 participants, data on serum vitamin B12 were available through the Nutrihealth study. The estimated usual population-weighted mean daily vitamin B12 intakes were 6.2 µg (adults), 5.4. µg (adolescents), and 5.0 µg (elderly). Lower intakes were observed in females. Inadequate daily vitamin B12 intake (<4 µg) was detected in 37.3% of adolescents, 31.7% of adults, and 58.3% elderlies. The significant predictors for inadequate daily vitamin B12 intake were physical activity score in all age groups, sex in adolescents and adults, financial status and smoking in elderly, and employment in adults. Meat (products), followed by milk (products), made the highest vitamin B12 contribution in all age groups. In adolescents, another important vitamin B12 contributor was cereals. The mean population-weighted serum vitamin B12 levels were 322.1 pmol/L (adults) and 287.3 pmol/L (elderly). Low serum vitamin B12 concentration (<148 nmol/L) and high serum homocysteine (>15 µmol/L) were used as criteria for vitamin B12 deficiency. The highest deficiency prevalence was found in elderlies (7.0%), particularly in males (7.9%). Factors associated with high serum homocysteine were also investigated. In conclusion, although vitamin B12 status was generally not critical, additional attention should be focused particularly to the elderly.


Author(s):  
Imelda Rosalyn Sianipar ◽  
Irena Ujianti ◽  
Sophie Yolanda ◽  
Ahmad Aulia Jusuf ◽  
Neng Tine Kartinah ◽  
...  

Background <br />Nonalcoholic fatty liver disease (NAFLD) is one of the most widespread chronic liver diseases, caused by the development of insulin resistance. One of the mechanisms involved is a disturbance in insulin signaling by certain toxic substances that interact with one of the proteins responsible for the insulin signaling pathway. Increased homocysteine level, upon disruption of the methionine pathway, is associated with insulin resistance. The aim of this study was to evaluate the effect of hyperhomocysteinemia and insulin resistance (HOMA-IR level) induced by dietary vitamin B12 restriction on liver steatosis. <br /><br />Methods <br />A study of laboratory experimental design was conducted involving 18 male Sprague Dawley rats (age 36-40 weeks, BW 300-350 g), that were randomly divided into 3 groups: control, 8-week treatment, and 16-week treatment. Standard AIN-93 diet was administered to the control group, whereas rats in the treatment groups were fed vitamin B12 deficiency-AIN-93M. At the end of treatment, liver homocysteine levels were determined by ELISA, HOMA-IR values were calculated, and steatosis degree of the liver was determined histologically. Statistical analysis was performed using independent t-test. <br /><br />Results <br />A significant increase in liver homocysteine levels was found between the control and both the 8- and 16-week treatment groups (p&lt;0.001). HOMA-IR levels were significantly higher in both treatment groups compared to controls (p&lt;0.001). The area of liver steatosis in both treatment groups was significantly larger than that of the control group (p&lt;0.001). <br /><br />Conclusion <br />Increased homocysteine levels due to dietary vitamin B12 deficiency induces liver steatosis due to insulin resistance in rats.


1984 ◽  
Vol 145 (6) ◽  
pp. 671-671 ◽  
Author(s):  
Frank Rawlinson ◽  
John M. Eagles

1997 ◽  
Vol 27 (2) ◽  
pp. 155-158 ◽  
Author(s):  
Karl-Olof Lövblad ◽  
Gianpaolo Ramelli ◽  
Luca Remonda ◽  
Arto C. Nirkko ◽  
Christoph Ozdoba ◽  
...  

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