scholarly journals GATA3 expression in the solid cell nest of thyroid

2020 ◽  
Vol 63 (3) ◽  
pp. 493
Author(s):  
Suvendu Purkait ◽  
Pavithra Ayyanar ◽  
Suvradeep Mitra
Keyword(s):  
Gata3 Expression ◽  
Solid Cell

scholarly journals Novel, Non–Gene-Destructive Knock-In Reporter Mice Refute the Concept of Monoallelic Gata3 Expression

2020 ◽  
Vol 204 (9) ◽  
pp. 2600-2611
Author(s):  
Tata Nageswara Rao ◽  
Suresh Kumar ◽  
Alex Jose Pulikkottil ◽  
Franziska Oliveri ◽  
Rudi W. Hendriks ◽  
...  
Keyword(s):  
Reporter Mice ◽  
Gata3 Expression

scholarly journals Gata3 drives development of RORγt+ group 3 innate lymphoid cells

2014 ◽  
Vol 211 (2) ◽  
pp. 199-208 ◽  
Author(s):  
Nicolas Serafini ◽  
Roel G.J. Klein Wolterink ◽  
Naoko Satoh-Takayama ◽  
Wei Xu ◽  
Christian A.J. Vosshenrich ◽  
...  
Keyword(s):  
T Cell ◽  
Fetal Liver ◽  
Innate Lymphoid Cells ◽  
Lymphoid Cells ◽  
T Cell Subsets ◽  
Mucosal Barrier ◽  
Hematopoietic Stem ◽  
Mucosal Surfaces ◽  
Gata3 Expression ◽  
Group 3

Group 3 innate lymphoid cells (ILC3) include IL-22–producing NKp46+ cells and IL-17A/IL-22–producing CD4+ lymphoid tissue inducerlike cells that express RORγt and are implicated in protective immunity at mucosal surfaces. Whereas the transcription factor Gata3 is essential for T cell and ILC2 development from hematopoietic stem cells (HSCs) and for IL-5 and IL-13 production by T cells and ILC2, the role for Gata3 in the generation or function of other ILC subsets is not known. We found that abundant GATA-3 protein is expressed in mucosa-associated ILC3 subsets with levels intermediate between mature B cells and ILC2. Chimeric mice generated with Gata3-deficient fetal liver hematopoietic precursors lack all intestinal RORγt+ ILC3 subsets, and these mice show defective production of IL-22 early after infection with the intestinal pathogen Citrobacter rodentium, leading to impaired survival. Further analyses demonstrated that ILC3 development requires cell-intrinsic Gata3 expression in fetal liver hematopoietic precursors. Our results demonstrate that Gata3 plays a generalized role in ILC lineage determination and is critical for the development of gut RORγt+ ILC3 subsets that maintain mucosal barrier homeostasis. These results further extend the paradigm of Gata3-dependent regulation of diversified innate ILC and adaptive T cell subsets.

Lymphoepithelial Cysts of the Thyroid Gland

2003 ◽  
Vol 127 (4) ◽  
pp. e205-e208
Author(s):  
Elliot Carter ◽  
Ozlem Ulusarac
Keyword(s):  
Thyroid Gland ◽  
Chronic Lymphocytic Thyroiditis ◽  
Chronic Thyroiditis ◽  
Lymphocytic Thyroiditis ◽  
Gland Tissue ◽  
Lymphoepithelial Cysts ◽  
Stratified Squamous Epithelium ◽  
Branchial Cleft ◽  
Solid Cell ◽  
Branchial Cleft Cysts

Abstract We report a case of multiple lymphoepithelial cysts of the thyroid gland in a patient with severe chronic lymphocytic thyroiditis. Lymphoepithelial cysts of the thyroid gland are rare lesions that are histologically similar to branchial cleft cysts found in the lateral neck. The cysts have an epithelial lining that is usually stratified squamous epithelium but may be focally respiratory-type epithelium. Abundant lymphoid tissue is present beneath the epithelium, and lymphoid follicles with reactive germinal centers are common features in the walls of the cysts. Because of their similarity to branchial cleft cysts and the presence of intrathyroidal branchiae-derived structures such as thymus and parathyroid gland tissue in the vicinity of some cysts, lymphoepithelial cysts of the thyroid have been postulated to arise from remnants of branchial derivatives; origination from solid cell nest remnants of the ultimobranchial bodies has been raised as a possibility. A definitive origin, however, has not been established. An association with chronic thyroiditis has been noted in 8 of the previously reported 16 cases occurring in a background of Hashimoto or chronic lymphocytic thyroiditis.

Intrathyroidal Branchial Cleft-like Cyst with Heterotopic Salivary Gland-type Tissue

2004 ◽  
Vol 7 (3) ◽  
pp. 262-267 ◽  
Author(s):  
Ji-Young Park ◽  
Gou Young Kim ◽  
Yeon-Lim Suh
Keyword(s):  
Salivary Gland ◽  
Fibrous Tissue ◽  
Lymphoid Tissues ◽  
Lateral Neck ◽  
Fat Tissue ◽  
Branchial Cleft ◽  
Well Differentiated ◽  
Solid Cell ◽  
Gland Type ◽  
And Cartilage

A rare case is described of intrathyroidal branchial cleft-like cyst associated with unusual heterotopic tissues including the salivary gland type tissue, fat, and cartilage. This coexistence in the thyroid gland has not been described previously, to our knowledge. The patient was a 7-year-old girl with a growing mass in the left lateral neck. The ultrasonography revealed a cystic lesion in the left thyroid. Histologically, the cyst was lined by squamous or respiratory-type epithelium resting on the fibrous tissue containing lymphoid tissues with follicle formation and solid cell nests (SCNs). This cyst was intimately associated with heterotopic tissues including lobules of well-differentiated seromucinous salivary glands, mature fat tissue, and islands of the cartilage. This association of branchial cleft-like cyst with SCNs and unusual heterotopic tissues in the normal thyroid suggests a possible origin from the SCN as ultimobranchial vestigial structures.

scholarly journals A Case Report: A Third/Fourth Branchial Pouch Anomaly Presented by Solid Thyroid and Lateral Cervical Neck Masses

2016 ◽  
Vol 9 ◽  
pp. CPath.S31734 ◽  
Author(s):  
Magda H. A. Nasreldin ◽  
Eman A. Ibrahim ◽  
Somaia A. Saad El-Din
Keyword(s):  
Rare Case ◽  
Histopathological Examination ◽  
Parathyroid Tissue ◽  
Thyroid Tumor ◽  
Cervical Lymph Nodes ◽  
Neck Masses ◽  
Malignant Thyroid Tumor ◽  
Branchial Arches ◽  
Thyroid Swelling ◽  
Solid Cell

Branchial pouch-derived anomalies may arise from remnants of the first, second, or third/fourth branchial arches. Branchial pouch-related structures are found within the thyroid gland in the form of solid cell rests, epithelial lined cyst with or without an associated lymphoid component, thymic and/or parathyroid tissue, and less commonly in the form of heterotopic cartilage. We present a rare case of left solid thyroid swelling nearby two cervical nodules in a seven-year-old female with a clinical diagnosis suggestive of malignant thyroid tumor with metastasis to the cervical lymph nodes. Histopathological examination revealed that it was compatible with third/fourth branchial pouch-derived anomaly composed of mature cartilage and thymic and parathyroid tissues for clinical and radiological correlations.

Enforced Gata3 Expression Increases Susceptibility To Allergic Airway Inflammation In Mice

2011 ◽  
Vol 127 (2) ◽  
pp. AB58-AB58
Author(s):  
A. KleinJan ◽  
M.J.W. De Bruijn ◽  
Y. Levani ◽  
M. Van Nimwegen ◽  
H.C. Hoogsteden ◽  
...  
Keyword(s):  
Airway Inflammation ◽  
Allergic Airway Inflammation ◽  
Gata3 Expression
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