Histomorphometrical study of the tongue epithelium of the peregrine falcon (Falco peregrinus)

The aim of this study is to examine the dorsal lingual epithelium of the peregrine falcon (Falco peregrinus) of the family Falconidae. The tongue in its dorsal, lateral and ventral surfaces is covered with a non-keratinized multilayered stratified squamous epithelium. Lamina propria is present beneath the epithelial layers. Morphometrically, thickness of the apex tongue epithelium is more than that in the tongue body. Thickness of the ventral surface of the tongue is less than that in the dorsal one. Thickness of the lateral surface of the tongue was thicker than that in the ventral one and tongue body. Large and small conical papillae appeared on the posterior dorsal surface of the lingual body. There are lingual glands in certain areas of tongue body with numerous openings through the dorsal surface.

Proliferative activity of the epithelium in squamous epithelial lesions of the cervix

As a criterion for precancerous changes in the stratified squamous epithelium of the cervix, its proliferative activity, studied using monoclonal antibodies PC-10 to the antigen of proliferating cell nuclei (PCNA), is considered. The results of the studies showed that patients with a low degree of squamous intraepithelial lesion are characterized by weak proliferative activity, and for patients with a high degree of lesion it is moderate and pronounced. An increase in proliferative activity is a prognostic factor that determines long-term persistence and the likely progression of the lesion.

Dysplasia in Papilloma at the Tip of the Tongue; A Rare Entity-Importance of on Time Prevention

Background: Oral papilloma is benign lesion while there is concern about high-risk types of Human Papilloma Virus (HPV) for cancer. Case Presentation: The patient was a 30-year-old woman who presented to the School of Dentistry, Semnan University of Medical Sciences for orthodontic treatment. Intraoral examinations revealed a prominent white papule on the tip of the tongue. Histopathologic exanimation revealed the proliferation of hyper keratinized stratified squamous epithelium arranged in projections with fibrovascular connective tissue cores, cell irregularity with hyperchromatic nucleus and koilocytes within the epithelium which confirmed the diagnosis of squamous papilloma (SP) with mild to moderate dysplasia. The patient was instructed to take care of the sexual behaviors and the injection of Gardasil vaccine was recommended. A month later, there was no evidence of a lesion. Conclusion: Though SPs are common lesions in the oral cavity, occurrence of dysplasia on SPs on the anterior part of the mouth is rare. Surgical removal supplemented by administration of Gardasil vaccine can be the treatment of choice in these cases. The significance of close attention to the oral lesions and consultation with an Oral and Maxillofacial Medicine Specialist is highly recommended in order to accurate diagnosis and timely treatment.

Estimation Of Pathomorphological Peculiarities Of Perivulnar Tissue After Ultrasonic Curettage Of Pilonidal Cysts Of Sacro-Coccygeal Region

The results of morphological research of operative wound’s tissue after ultrasonic curettage of acute pilonidal abscess are presented in the article. 13 patients were treated using the offered method, and of these, 11 patients underwent morphological research of the wound’s walls. Areas of the mucoid degeneration of the fibrous connective tissue and fragments of coagulation necrosis were identified, as a result of low-frequency ultrasound. The morphological substrates of recurrence pilonidal sinus, such as stratified squamous epithelium and hair follicles, were not found in any preparation, The offered method of treatment allows for ambulatory primary radical treatment in theacute stage of pilonidal illness. The offered method of ultrasonic curettage of the pilonidal sinus requires more scientific research and monitoring.

A Rare Case of Facial Multiple Epidermal Cysts: Successfully Treated by Surgical Excision

Background Epidermal cysts are common skin tumors that are composed of a keratinocytic cyst wall and central keratin material, which can occur anywhere in the body, especially on the face. However, there are no relevant reports of multiple epidermal cysts coexisting at the same location.Case presentation Here, we report one rare case of facial multiple epidermal cysts, who underwent sequential resection of all cysts. A 45-year-old male presented with facial multiple masses for over 2 years. Physical examination showed multiple cysts with varied sizes on the face. All cysts were smooth, dome-shaped, freely movable, and some of them were attached to the skin by a central pore. The histopathology revealed cysts in the dermis, the wall of which were composed of stratified squamous epithelium, and the cavity were filled with keratin. Therefore, the patient was diagnosed as facial multiple epidermal cysts.Conclusions This is the first well-documented case of multiple epidermal cysts on the face. We report this rare case to highlight that although epidermal cysts usually appear single, they may also appear multiple in the same location, especially in those patients with vigorous sebaceous gland function. Surgical excision is the first-line effective treatment for epidermal cysts.

Case Report: Giant Epidermoid Cyst on the Neck with Hypopharyngeal Propulsion

Introduction: Dermoid cyst is a cystic mass lined with stratified squamous epithelium with skin adnexal structure. Histopathologically dermoid cysts consist of 3 types, namely epidermoid cysts, true dermoid cysts and teratoid cysts. Epidermoid cysts are characterized by masses with a simple squamous epithelial lining. When the cyst ruptures, it releases a cheesy white matter that smells bad. Epidermoid cysts are most commonly found in the age range of 15 and 35 years with almost the same frequency between male and female sexes. Case description: We report a case of a 52-year-old man with a lump on the left side of the neck that has been slowly growing since 1 year and a computer tomography of the neck suspected a cyst in the anterior glottis. The patient was diagnosed as a neck cyst. Management was carried out by excision of the cyst under general anesthesia and histopathological examination with the results of an Epidermoid cyst. Conclusion: Epidermoid cysts can develop in any part of the body, but are very rare on the head and neck. Definitive management of epidermoid cysts with complete excision of the cyst gives satisfactory results Keywords: Giant Epidermoid Cyst, excision, hypopharyngeal propulsion

Cecal epidermoid cyst: a neonatal case with clinicopathological consideration

Background Only 10 cases of cecal epidermoid cyst (CEC) have been reported in the literature. Furthermore, its pathogenesis remains unclear. We report a rare case of congenital CEC in neonate, and discuss its clinicopathological findings. Case presentation A cystic lesion was incidentally identified in the retroperitoneal area of the abdominal right lower quadrant during a routine prenatal ultrasonography (US), prompting an ileocolectomy 3 days after birth. This congenital cyst was composed of mucosal lining cells and submucosal connective tissues, and the inner lining mucosa was composed of stratified squamous epithelium and focally mucin-producing ciliated epithelium. Based on the macroscopic and microscopic findings, the cystic lesion was diagnosed as a congenital cecal epidermoid cyst. Conclusions The management of a fetal abdominal mass should be tailored individually, considering that epidermoid cysts can occur in the cecum during the perinatal period. We report the clinicopathological findings in this case, including its possible pathogenesis.

Immunolocalization of Antibacterial Peptide S100A7 in Goat Mammary Gland and Lipopolysaccharide Induces the Expression and Secretion of S100A7 in Goat Mammary Gland Epithelial Cells via TLR4/NFκB Signal Pathway

Background: The antimicrobial peptide (AMP) S100A7, with antimicrobial activities for a broad spectrum of bacteria, have attracted more and more attention for the prevention and treatment of mastitis. However, in goat mastitis, there is little information about the expression and regulation mechanism of S100A7. In present study, the immunolocalization of S100A7 in healthy and mastitis goat udder were compared. In order to further explore the regulatory mechanism of S100A7 expression in mammary epithelial cells (MECs), goat MECs were isolated and treated by 2.5, 5, 10 and 20 μg/mL lipopolysaccharide (LPS) respectively for different time.Results: Both in healthy and mastitis goat teat, S100A7 was mainly expressed in stratified squamous epithelium of teat skin and streak canal. In healthy goat mammary gland, weakly S100A7 immunoreactivity was present in the alveolus. But in the collapsed alveolus of mastitis goat mammary gland, densely S100A7 immunoreactivity could be observed.The goat MECs were treated by 2.5, 5, 10 and 20 μg/mL LPS respectively for different time. For all of these four groups, after treatment for 3 h, increase in S100A7 mRNA expression and protein secretion were detected compared to control (p<0.05). For 10 and 20μg/mL LPS groups, after treatment for 6 h, the mRNA and secreted protein levels of S100A7 were remarkably up-regulated compared to control(p<0.01). For all of these four groups, the secretion level of S100A7 descended after 48 h treatment. Moreover, after treatment with LPS, the mRNA levels of Toll-like receptor 4(TLR4) and MyD88 were up-regulated, and the phosphorylation of p65 was up-regulated markedly compared to control. However, adding TLR4 inhibitor TAK-242 or/and NF-κB inhibitor QNZ significantly suppressed the phosphorylation of p-65，and then inhibited the expression and secretion of S100A7 induced by LPS treatment.Conclusions: S100A7 was mainly expressed in stratified squamous epithelium of teat skin and streak canal. In mastitis goat mammary gland alveolus, the expression level of S100A7 was up-regulated compared to that in healthy goat. LPS induced the expression and secretion of S100A7 in goat MECs depended on concentration and treatment duration. Moreover, LPS induced the expression and secretion of S100A7 in goat MECs via TLR4/NF-κB signaling pathway.

Isolated keratinising corneal ocular surface squamous neoplasia with multifocal recurrence

Corneal ocular surface squamous neoplasia usually begins at the limbus and presents as an avascular translucent sheet over the corneal surface. This case report describes a 67-year-old man with an unusual isolated, keratinous nodular corneal lesion. Slit-lamp examination showed an elevated, avascular, whitish plaque-like lesion at the central cornea surrounded by a normal corneal epithelium, with reduced visual acuity of 20/200 in the right eye. Anterior segment optical coherence tomography displayed a hyper-reflective, thickened epithelium with back shadowing. Histopathology showed keratinising hyperplastic stratified squamous epithelium with parakeratosis and moderate nuclear pleomorphism in lower second/third of epithelium suggestive of moderate dysplasia. His visual acuity returned to 20/20 after surgical excision but he developed multifocal corneal recurrences 6 weeks later, which were successfully managed with seven cycles of topical interferon immunotherapy. There are no recurrences observed at 6 months of follow-up.

Compound haemangioma of lower lip: an interesting and rare case report

Haemangiomas are common benign vascular tumours of infancy and childhood. Haemangiomas occur in 10-12% of children of 1 year of age and most of them are self-resolving within 9 years of age. Most common sites are head and neck (around 90%) and lip is one of the preferred sites. Sometimes persistence of haemangiomas may require surgical intervention. Capillary haemangiomas generally located superficially and cavernous haemangiomas located deep. Mixed capillary-cavernous haemangiomas or compound haemangiomas are one of the rarer types and location at lip rarest. Here we report a 14-years-old boy presented to paediatric surgery outdoor with swelling in lower lip for last 3 years. The excisional biopsy done with a clinical diagnosis of granuloma and sent for histopathological study. On microscopy of tissue sections given from lesion showed stratified squamous epithelium with sub epithelium revealing two distinct areas of capillary haemangioma component and cavernous haemangioma component within the lesion. So, final diagnosis of capillary-cavernous haemangioma (compound haemangioma) was made without any granuloma or malignant component. Patient followed up for six months and he was completely asymptomatic without any residual disease and recurrence.