Role of circulating endothelial progenitor cells in patients with breast cancer

2019 ◽  
Vol 32 (3) ◽  
pp. 770
Author(s):  
AsmaaS Abo El-Yazeed ◽  
LailaM Montaser ◽  
AhmedA Sonbol ◽  
AhmedS EL-Gammal
2013 ◽  
Vol 61 (10) ◽  
pp. E1371
Author(s):  
Francesca Felice ◽  
Rossella Di Stefano ◽  
Stefano Pini ◽  
Gianfranco Mazzotta ◽  
Francesco M. Bovenzi ◽  
...  

Lung Cancer ◽  
2005 ◽  
Vol 49 ◽  
pp. S368-S369
Author(s):  
B. Dome ◽  
J. Timar ◽  
G. Ostoros ◽  
L. Meszaros ◽  
J. Dobos ◽  
...  

2019 ◽  
Vol 392 (6) ◽  
pp. 669-683 ◽  
Author(s):  
Jolly Mounir William Labib ◽  
Sawsan Aboul-Fotouh ◽  
Mohamed Z. Habib ◽  
Mohamed Abd Elrahman Ahmed Mekawy ◽  
Kawthar A. Farrag ◽  
...  

2019 ◽  
Vol 40 (Supplement_1) ◽  
Author(s):  
Y.-H Chan ◽  
M C Ngai ◽  
Y Chen ◽  
M Z Wu ◽  
Y J Yu ◽  
...  

Abstract Background Rheumatoid arthritis is associated with both abnormal bone metabolism and atherogenesis but mechanistic links were missing. Aim This study aimed to investigate the role of osteocalcin (OCN)-expressing circulating endothelial progenitor cells (EPC)s in the severity and dissemination of systemic arterial calcifications in rheumatoid arthritis. Methods We performed flow cytometry studies in 145 consecutive patients with rheumatoid arthritis to determine osteogenic circulating levels of OCN-positive (OCN+) CD34+KDR+ and OCN+CD34+, versus conventional early EPC CD34+CD133+KDR+. Total calcium load of the thoracic aorta (ascending plus descending) and the carotid arteries were assessed by non-contrast computed tomography (CT) and contrast CT angiography. Results Osteogenic EPCs OCN+CD34+KDR+ (P=0.002) and OCN+CD34+ were strikingly associated with the clustered presence of aortic and carotid calcification (P=0.002 and 0.001 respectively, Figure). Multivariable analyses revealed that circulating OCN+CD34+KDR+ (B=14.4 [95% CI 4.0 to 24.8], P=0.007) and OCN+CD34+ (B=9.6 [95% CI 4.9 to 14.3], P<0.001) remained independently associated with increased aortic calcium load. OCN+CD34+ EPC (B=0.8 [95% CI 0.1 to 1.5], P=0.023), but not OCN+CD34+KDR+ EPC (B=1.2 [95% CI −0.2 to 2.6], P=0.09) was further independently associated with carotid calcium load. In comparison, conventional early EPC CD34+CD133+KDR+ had no significant association with aortic or carotid calcium load (P=0.46 and 0.88, respectively). Conclusions Circulating level of osteogenic EPC is associated with promulgated aortic and carotid calcification in patients with rheumatoid arthritis, suggesting a potential mechanistic role of the bone-vascular axis in pro-atherogenicity of rheumatic diseases. Acknowledgement/Funding General Research Fund, Hong Kong Research Grants Council


2013 ◽  
Vol 325 (1-2) ◽  
pp. 90-99 ◽  
Author(s):  
E. Paczkowska ◽  
M. Gołąb-Janowska ◽  
A. Bajer-Czajkowska ◽  
A. Machalińska ◽  
P. Ustianowski ◽  
...  

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