scholarly journals H3 and H4 Lysine Acetylation Correlates with Developmental and Experimentally Induced Adult Experience-Dependent Plasticity in the Mouse Visual Cortex

2016 ◽  
Vol 10s1 ◽  
pp. JEN.S39888 ◽  
Author(s):  
Gabriela Vierci ◽  
Bruno Pannunzio ◽  
Natalia Bornia ◽  
Francesco M. Rossi
Keyword(s):  
Visual Cortex ◽  
Posttranslational Modifications ◽  
Visual Experience ◽  
High Plasticity ◽  
Experimental Conditions ◽  
Dynamic Regulation ◽  
Dependent Plasticity ◽  
Fluoxetine Treatment ◽  
Mouse Visual Cortex ◽  
Adult Plasticity

Histone posttranslational modifications play a fundamental role in orchestrating gene expression. In this work, we analyzed the acetylation of H3 and H4 histones (AcH3-AcH4) and its modulation by visual experience in the mouse visual cortex (VC) during normal development and in two experimental conditions that restore juvenile-like plasticity levels in adults (fluoxetine treatment and enriched environment). We found that AcH3-AcH4 declines with age and is upregulated by treatments restoring plasticity in the adult. We also found that visual experience modulates AcH3-AcH4 in young and adult plasticity-restored mice but not in untreated ones. Finally, we showed that the transporter vGAT is downregulated in adult plasticity-restored models. In summary, we identified a dynamic regulation of AcH3-AcH4, which is associated with high plasticity levels and enhanced by visual experience. These data, along with recent ones, indicate H3-H4 acetylation as a central hub in the control of experience-dependent plasticity in the VC.

scholarly journals Audio-visual experience strengthens multisensory assemblies in adult mouse visual cortex

2019 ◽  
Vol 10 (1) ◽  
Author(s):  
Thomas Knöpfel ◽  
Yann Sweeney ◽  
Carola I. Radulescu ◽  
Nawal Zabouri ◽  
Nazanin Doostdar ◽  
...  
Keyword(s):  
Visual Cortex ◽  
Visual Experience ◽  
Adult Mouse ◽  
Neural Circuits ◽  
Multisensory Processing ◽  
Functional Networks ◽  
Auditory Responses ◽  
Visual Events ◽  
Calcium Indicators ◽  
Mouse Visual Cortex

AbstractWe experience the world through multiple senses simultaneously. To better understand mechanisms of multisensory processing we ask whether inputs from two senses (auditory and visual) can interact and drive plasticity in neural-circuits of the primary visual cortex (V1). Using genetically-encoded voltage and calcium indicators, we find coincident audio-visual experience modifies both the supra and subthreshold response properties of neurons in L2/3 of mouse V1. Specifically, we find that after audio-visual pairing, a subset of multimodal neurons develops enhanced auditory responses to the paired auditory stimulus. This cross-modal plasticity persists over days and is reflected in the strengthening of small functional networks of L2/3 neurons. We find V1 processes coincident auditory and visual events by strengthening functional associations between feature specific assemblies of multimodal neurons during bouts of sensory driven co-activity, leaving a trace of multisensory experience in the cortical network.

Reversible blockade of experience-dependent plasticity by calcineurin in mouse visual cortex

2005 ◽  
Vol 8 (6) ◽  
pp. 791-796 ◽  
Author(s):  
Yupeng Yang ◽  
Quentin S Fischer ◽  
Ying Zhang ◽  
Karsten Baumgärtel ◽  
Isabelle M Mansuy ◽  
...  
Keyword(s):  
Visual Cortex ◽  
Dependent Plasticity ◽  
Mouse Visual Cortex

scholarly journals Brief Novel Visual Experience Fundamentally Changes Synaptic Plasticity in the Mouse Visual Cortex

2017 ◽  
Vol 37 (39) ◽  
pp. 9353-9360 ◽  
Author(s):  
Shuo Li ◽  
Laijian Wang ◽  
Xiaoxiu Tie ◽  
Kazuhiro Sohya ◽  
Xian Lin ◽  
...  
Keyword(s):  
Synaptic Plasticity ◽  
Visual Cortex ◽  
Visual Experience ◽  
Mouse Visual Cortex

scholarly journals Instructive Effect of Visual Experience in Mouse Visual Cortex

Neuron ◽  
2006 ◽  
Vol 51 (3) ◽  
pp. 339-349 ◽  
Author(s):  
Mikhail Y. Frenkel ◽  
Nathaniel B. Sawtell ◽  
Antonia Cinira M. Diogo ◽  
Bongjune Yoon ◽  
Rachael L. Neve ◽  
...  
Keyword(s):  
Visual Cortex ◽  
Visual Experience ◽  
Mouse Visual Cortex

scholarly journals Spatial modulation of dark versus bright stimulus responses in mouse visual cortex

2020 ◽  
Author(s):  
Brice Williams ◽  
Joseph Del Rosario ◽  
Stefano Coletta ◽  
Edyta K. Bichler ◽  
Tomaso Muzzu ◽  
...  
Keyword(s):  
Visual Cortex ◽  
Membrane Potential ◽  
Field Potential ◽  
Visual Space ◽  
Spatial Modulation ◽  
Single Neurons ◽  
Central Visual Field ◽  
Experimental Conditions ◽  
Whole Cell Patch Clamp ◽  
Mouse Visual Cortex

AbstractA fundamental task of the visual system is to respond to luminance increments and decrements. In primary visual cortex (V1) of cats and primates, luminance decrements elicit stronger, faster, and more salient neural activity (OFF responses) than luminance increments (ON responses). However, studies of V1 in ferrets and mice show that ON responses may be stronger. These discrepancies may arise from differences in species, experimental conditions, or from measuring responses in single neurons versus populations. Here, we examined OFF versus ON responses across different regions of visual space in both single neurons and populations of mouse V1. We used high-density silicon probes and whole-cell patch-clamp recordings to assess OFF versus ON dominance in local field potential (LFP), single neuron, and membrane potential responses. Across these levels, we found that OFF responses clearly dominated in the central visual field, whereas ON responses were more evident in the periphery. These observations were clearest in LFP and subthreshold membrane potential. Our findings consolidate and resolve prior conflicting results and reveal that retinotopy may provide a common organizing principle for spatially biasing OFF versus ON processing in mammalian visual systems.

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