scholarly journals Altered Visual Experience Induces Instructive Changes of Orientation Preference in Mouse Visual Cortex

2011 ◽  
Vol 31 (39) ◽  
pp. 13911-13920 ◽  
Author(s):  
A. K. Kreile ◽  
T. Bonhoeffer ◽  
M. Hubener
Keyword(s):  
Visual Cortex ◽  
Visual Experience ◽  
Orientation Preference ◽  
Mouse Visual Cortex

scholarly journals Audio-visual experience strengthens multisensory assemblies in adult mouse visual cortex

2019 ◽  
Vol 10 (1) ◽  
Author(s):  
Thomas Knöpfel ◽  
Yann Sweeney ◽  
Carola I. Radulescu ◽  
Nawal Zabouri ◽  
Nazanin Doostdar ◽  
...  
Keyword(s):  
Visual Cortex ◽  
Visual Experience ◽  
Adult Mouse ◽  
Neural Circuits ◽  
Multisensory Processing ◽  
Functional Networks ◽  
Auditory Responses ◽  
Visual Events ◽  
Calcium Indicators ◽  
Mouse Visual Cortex

AbstractWe experience the world through multiple senses simultaneously. To better understand mechanisms of multisensory processing we ask whether inputs from two senses (auditory and visual) can interact and drive plasticity in neural-circuits of the primary visual cortex (V1). Using genetically-encoded voltage and calcium indicators, we find coincident audio-visual experience modifies both the supra and subthreshold response properties of neurons in L2/3 of mouse V1. Specifically, we find that after audio-visual pairing, a subset of multimodal neurons develops enhanced auditory responses to the paired auditory stimulus. This cross-modal plasticity persists over days and is reflected in the strengthening of small functional networks of L2/3 neurons. We find V1 processes coincident auditory and visual events by strengthening functional associations between feature specific assemblies of multimodal neurons during bouts of sensory driven co-activity, leaving a trace of multisensory experience in the cortical network.

scholarly journals Brief Novel Visual Experience Fundamentally Changes Synaptic Plasticity in the Mouse Visual Cortex

2017 ◽  
Vol 37 (39) ◽  
pp. 9353-9360 ◽  
Author(s):  
Shuo Li ◽  
Laijian Wang ◽  
Xiaoxiu Tie ◽  
Kazuhiro Sohya ◽  
Xian Lin ◽  
...  
Keyword(s):  
Synaptic Plasticity ◽  
Visual Cortex ◽  
Visual Experience ◽  
Mouse Visual Cortex

Visual experience regulates the development of long-term synaptic modifications induced by low-frequency stimulation in mouse visual cortex

2017 ◽  
Vol 120 ◽  
pp. 36-44 ◽  
Author(s):  
Taketoshi Sugimura ◽  
Mariko Yamamoto ◽  
Kazumasa Yamada ◽  
Yukio Komatsu ◽  
Yumiko Yoshimura
Keyword(s):  
Visual Cortex ◽  
Visual Experience ◽  
Low Frequency ◽  
Low Frequency Stimulation ◽  
Frequency Stimulation ◽  
Mouse Visual Cortex

scholarly journals Instructive Effect of Visual Experience in Mouse Visual Cortex

Neuron ◽  
2006 ◽  
Vol 51 (3) ◽  
pp. 339-349 ◽  
Author(s):  
Mikhail Y. Frenkel ◽  
Nathaniel B. Sawtell ◽  
Antonia Cinira M. Diogo ◽  
Bongjune Yoon ◽  
Rachael L. Neve ◽  
...  
Keyword(s):  
Visual Cortex ◽  
Visual Experience ◽  
Mouse Visual Cortex

scholarly journals H3 and H4 Lysine Acetylation Correlates with Developmental and Experimentally Induced Adult Experience-Dependent Plasticity in the Mouse Visual Cortex

2016 ◽  
Vol 10s1 ◽  
pp. JEN.S39888 ◽  
Author(s):  
Gabriela Vierci ◽  
Bruno Pannunzio ◽  
Natalia Bornia ◽  
Francesco M. Rossi
Keyword(s):  
Visual Cortex ◽  
Posttranslational Modifications ◽  
Visual Experience ◽  
High Plasticity ◽  
Experimental Conditions ◽  
Dynamic Regulation ◽  
Dependent Plasticity ◽  
Fluoxetine Treatment ◽  
Mouse Visual Cortex ◽  
Adult Plasticity

Histone posttranslational modifications play a fundamental role in orchestrating gene expression. In this work, we analyzed the acetylation of H3 and H4 histones (AcH3-AcH4) and its modulation by visual experience in the mouse visual cortex (VC) during normal development and in two experimental conditions that restore juvenile-like plasticity levels in adults (fluoxetine treatment and enriched environment). We found that AcH3-AcH4 declines with age and is upregulated by treatments restoring plasticity in the adult. We also found that visual experience modulates AcH3-AcH4 in young and adult plasticity-restored mice but not in untreated ones. Finally, we showed that the transporter vGAT is downregulated in adult plasticity-restored models. In summary, we identified a dynamic regulation of AcH3-AcH4, which is associated with high plasticity levels and enhanced by visual experience. These data, along with recent ones, indicate H3-H4 acetylation as a central hub in the control of experience-dependent plasticity in the VC.

Visual experience promotes the isotropic representation of orientation preference

2004 ◽  
Vol 21 (1) ◽  
pp. 39-51 ◽  
Author(s):  
DAVID M. COPPOLA ◽  
LEONARD E. WHITE
Keyword(s):  
Visual Cortex ◽  
Visual Experience ◽  
Mammalian Species ◽  
Orientation Selectivity ◽  
Orientation Preference ◽  
Intrinsic Signal ◽  
Degree Of Orientation ◽  
Degree Of Anisotropy ◽  
Eye Opening ◽  
Cortical Maturation

Within the visual cortex of several mammalian species, more circuitry is devoted to the representation of vertical and horizontal orientations than oblique orientations. The sensitivity of this representation of orientation preference to visual experience during cortical maturation and the overabundance of cardinal contours in the environment suggest that vision promotes the development of this cortical anisotropy. We tested this idea by measuring the distribution of cortical orientation preference and the degree of orientation selectivity in developing normal and dark-reared ferrets using intrinsic signal optical imaging. The area of the angle map of orientation preference representing cardinal and oblique orientations was determined; in addition, orientation selectivity indices were computed separately for cardinal and oblique difference images. In normal juvenile animals, we confirm a small, but statistically significant overrepresentation of near horizontal orientations in the cortical angle map. However, the degree of anisotropy did not increase in the weeks that followed eye opening when orientation selectivity matured; rather, it decreased. In dark-reared ferrets, an even greater cortical anisotropy emerged, but angle maps in these animals developed an apparently anomalous overrepresentation of near vertical orientations. Thus, the overrepresentation of cardinal orientations in the visual cortex does not require experience with an anisotropic visual environment; indeed, cortical anisotropy can develop in the complete absence of vision. These observations suggest that the role of visual experience in cortical maturation is to promote the isotropic representation of orientation preference.

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