EVIDENCE FOR A CENTRAL OPIOID CONTROL OF RUMINATION

1984 ◽  
Vol 64 (5) ◽  
pp. 13-15 ◽  
Author(s):  
Y. RUCKEBUSCH ◽  
TH. BARDON
Keyword(s):  
Key Words ◽  
Opioid Receptor ◽  
Opioid Receptors ◽  
Opioid Peptides ◽  
Kappa Opioid Receptor ◽  
Kappa Opioid ◽  
Receptor Agonists ◽  
Opioid Agonists ◽  
Reflex Control ◽  
Opioid Receptor Agonists

Intravenous adrenaline induced reticular extracontractions and rumination within 26 sec in hay-fed, and 184 sec in cube-fed sheep. Regardless of diet, pretreatment with cerebroventricular infusion of kappa-opioid-receptor agonists enhanced this reflex. Control of rumination may involve multiple opioid-receptors, since inhibition of the reflex occurred after mu- and delta-opioid-agonists. Key words: Sheep, rumination, opioid-peptides

scholarly journals Cover Feature: Synthesis and Assessment of Fused β‐Carboline Derivatives as Kappa Opioid Receptor Agonists (12/2021)

ChemMedChem ◽  
2021 ◽  
Vol 16 (12) ◽  
pp. 1834-1834
Author(s):  
Veena D. Yadav ◽  
Lalan Kumar ◽  
Poonam Kumari ◽  
Sakesh Kumar ◽  
Maninder Singh ◽  
...  
Keyword(s):  
Opioid Receptor ◽  
Kappa Opioid Receptor ◽  
Kappa Opioid ◽  
Receptor Agonists ◽  
Opioid Receptor Agonists

scholarly journals 6,5-Fused Ring, C2-Salvinorin Ester, Dual Kappa and Mu Opioid Receptor Agonists as Analgesics Devoid of Anxiogenic Effects

2021 ◽  
Author(s):  
Nicholas S. Akins ◽  
Nisha Mishra ◽  
Hannah M. Harris ◽  
Narendar Dudhipala ◽  
Seong Jong Kim ◽  
...  
Keyword(s):  
Opioid Receptor ◽  
Opioid Receptors ◽  
Analgesic Activity ◽  
Mu Opioid Receptor ◽  
Kappa Opioid Receptor ◽  
Mu Opioid ◽  
Receptor Agonists ◽  
Opioid Receptor Agonists

Analgesia is commonly mediated through the mu or kappa opioid receptor agonism. Unfortunately, selective mu or kappa receptor agonists often cause harmful side effects. Recently, ligands exhibiting dual agonism to the opioid receptors, such as to mu and kappa, or to mu and delta, have been suggested to temper undesirable adverse effects while retaining analgesic activity. Herein we report an introduction of various 6,5-fused rings to C2 of the salvinorin scaffold <i>via</i> an ester linker. <i>In vitro</i> studies showed that some of these compounds have dual agonism on kappa and mu opioid receptors, while some have triple agonism on kappa, mu, and delta. <i>In vivo </i>studies on the lead dual kappa and mu opioid receptor agonist, compound <b>10</b>, showed that it<b> </b>produced analgesic activity while avoiding anxiogenic effects in murine models, thus providing further strong evidence for the therapeutic advantages of dual opioid receptor agonists over selective opioid receptor agonists.

scholarly journals Structurally Related Kappa Opioid Receptor Agonists with Substantial Differential Signaling Bias: Neuroendocrine and Behavioral Effects in C57BL6 Mice

2018 ◽  
Vol 21 (9) ◽  
pp. 847-857 ◽  
Author(s):  
Amelia D Dunn ◽  
Brian Reed ◽  
Catherine Guariglia ◽  
Alexandra M Dunn ◽  
Joshua M Hillman ◽  
...  
Keyword(s):  
Opioid Receptor ◽  
Kappa Opioid Receptor ◽  
Behavioral Effects ◽  
Kappa Opioid ◽  
Receptor Agonists ◽  
Differential Signaling ◽  
Opioid Receptor Agonists

Inhibition of the neuronal nicotinic receptor-mediated current by kappa opioid receptor agonists in PC12 cells

1998 ◽  
Vol 436 (6) ◽  
pp. 887-893 ◽  
Author(s):  
Keikou Oka ◽  
T. Andoh ◽  
Itaru Watanabe ◽  
Yoshinori Kamiya ◽  
Hideki Ito
Keyword(s):  
Pc12 Cells ◽  
Opioid Receptor ◽  
Nicotinic Receptor ◽  
Kappa Opioid Receptor ◽  
Kappa Opioid ◽  
Neuronal Nicotinic Receptor ◽  
Receptor Agonists ◽  
Opioid Receptor Agonists

Kappa opioid receptor agonists inhibit the pilocarpine-induced seizures and toxicity in the mouse

1994 ◽  
Vol 4 (4) ◽  
pp. 527-533 ◽  
Author(s):  
B. Przewłocka ◽  
H. Machelska ◽  
W. Lasoń
Keyword(s):  
Opioid Receptor ◽  
Kappa Opioid Receptor ◽  
Kappa Opioid ◽  
Receptor Agonists ◽  
Opioid Receptor Agonists

Spinal mu and delta, but not kappa, opioid-receptor agonists attenuate responses to noxious colorectal distension in the rat

Pain ◽  
1995 ◽  
Vol 63 (1) ◽  
pp. 39-47 ◽  
Author(s):  
R. M. Danzebrink ◽  
S. A. Green ◽  
G. F. Gebhart
Keyword(s):  
Opioid Receptor ◽  
Kappa Opioid Receptor ◽  
Kappa Opioid ◽  
Colorectal Distension ◽  
Receptor Agonists ◽  
Opioid Receptor Agonists

scholarly journals Effect of kappa-opioid receptor agonists U69593, U50488H, spiradoline and salvinorin A on cocaine-induced drug-seeking in rats

2009 ◽  
Vol 94 (2) ◽  
pp. 244-249 ◽  
Author(s):  
Aashish S. Morani ◽  
Bronwyn Kivell ◽  
Thomas E. Prisinzano ◽  
Susan Schenk
Keyword(s):  
Opioid Receptor ◽  
Kappa Opioid Receptor ◽  
Salvinorin A ◽  
Kappa Opioid ◽  
Drug Seeking ◽  
Receptor Agonists ◽  
Opioid Receptor Agonists

scholarly journals Potential for Kappa-Opioid Receptor Agonists to Engineer Nonaddictive Analgesics: A Narrative Review

2020 ◽  
Author(s):  
Shane W. Kaski ◽  
Allison N. White ◽  
Joshua D. Gross ◽  
David P. Siderovski
Keyword(s):  
Opioid Receptor ◽  
Kappa Opioid Receptor ◽  
Narrative Review ◽  
Kappa Opioid ◽  
Receptor Agonists ◽  
Opioid Receptor Agonists

Kappa-opioid receptor agonists in pain treatment

2019 ◽  
Vol 44 (1) ◽  
pp. 39
Author(s):  
Jr., J.V. Pergolizzi ◽  
J.A. LeQuang ◽  
Jr., R. Taylor ◽  
M.H. Ossipov ◽  
R.B. Raffa
Keyword(s):  
Opioid Receptor ◽  
Pain Treatment ◽  
Kappa Opioid Receptor ◽  
Kappa Opioid ◽  
Receptor Agonists ◽  
Opioid Receptor Agonists
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