Evaluation of sample extraction methods for minimizing hematocrit effect on whole blood analysis with volumetric absorptive microsampling

Bioanalysis ◽  
2017 ◽  
Vol 9 (4) ◽  
pp. 349-357 ◽  
Author(s):  
Zhengqi Ye ◽  
Hong Gao
Keyword(s):  
Whole Blood ◽  
Extraction Methods ◽  
Blood Analysis ◽  
Sample Extraction ◽  
Whole Blood Analysis ◽  
Volumetric Absorptive Microsampling ◽  
Hematocrit Effect

Validation of methods for determining pediatric midazolam using wet whole blood and volumetric absorptive microsampling

Bioanalysis ◽  
2019 ◽  
Vol 11 (19) ◽  
pp. 1737-1754 ◽  
Author(s):  
Paul Abu-Rabie ◽  
Bikalpa Neupane ◽  
Neil Spooner ◽  
James Rudge ◽  
Philip Denniff ◽  
...  
Keyword(s):  
Whole Blood ◽  
Pediatric Patients ◽  
Blood Analysis ◽  
Pharmacokinetic Parameters ◽  
Validation Data ◽  
Bioanalytical Method ◽  
Whole Blood Analysis ◽  
Suitable Technique ◽  
Volumetric Absorptive Microsampling

Aim: Collection and quantitative analysis in dry blood using volumetric absorptive microsampling (VAMS™) potentially offers significant advantages over conventional wet whole blood analysis. This manuscript explores their use for pediatric sampling and explores additional considerations for the validation of the bioanalytical method. Results: HPLC–MS/MS methods for the determination of midazolam and its major metabolite 1-OH midazolam in both whole wet blood, and dry blood collected on VAMS were developed, validated, and used to support an observational clinical study to compare pharmacokinetic parameters in pediatric patients. Conclusion: Validation data met internationally accepted guideline criteria. A strong correlation was observed in calculated concentrations between wet and dry test samples, indicating that VAMS is a suitable technique for use in pediatric clinical studies.

Pneumatic-pumping metering in CD-like microfluidic chip for whole blood analysis

2014 ◽  
Vol 22 (10) ◽  
pp. 2733-2739 ◽  
Author(s):  
范建华 FAN Jian-hua ◽  
邓永波 DENG Yong-bo ◽  
宣明 XUAN Ming ◽  
周松 ZHOU Song ◽  
武俊峰 WU Jun-feng ◽  
...  
Keyword(s):  
Microfluidic Chip ◽  
Whole Blood ◽  
Blood Analysis ◽  
Whole Blood Analysis

Demonstration of whole blood analysis using proton-induced x-ray emission

1976 ◽  
Vol 3 (2) ◽  
pp. 91-94 ◽  
Author(s):  
J. J. Malanify ◽  
C. E. Burns ◽  
D. A. Close ◽  
R. C. Bearse
Keyword(s):  
Whole Blood ◽  
Blood Analysis ◽  
X Ray ◽  
Whole Blood Analysis

Whole blood analysis of kwashiorkor cases by PIXE

1981 ◽  
Vol 181 (1-3) ◽  
pp. 305-308 ◽  
Author(s):  
B. Spoelstra ◽  
J.P.F. Sellschop ◽  
H.J. Annegarn ◽  
M.J. Renan
Keyword(s):  
Whole Blood ◽  
Blood Analysis ◽  
Whole Blood Analysis

An electrochemical Lab-on-a-CD system for parallel whole blood analysis

Lab on a Chip ◽  
2013 ◽  
Vol 13 (13) ◽  
pp. 2634 ◽  
Author(s):  
Tingjie Li ◽  
Yaxi Fan ◽  
Yang Cheng ◽  
Jun Yang
Keyword(s):  
Whole Blood ◽  
Blood Analysis ◽  
Whole Blood Analysis

scholarly journals Micro Ion Extractor for Single Drop Whole Blood Analysis

2015 ◽  
Vol 87 (13) ◽  
pp. 6483-6486 ◽  
Author(s):  
Yukihide Nakamura ◽  
Shiori Maeda ◽  
Hiroka Nishiyama ◽  
Shin-Ichi Ohira ◽  
Purnendu K. Dasgupta ◽  
...  
Keyword(s):  
Whole Blood ◽  
Blood Analysis ◽  
Single Drop ◽  
Whole Blood Analysis

scholarly journals Early Prediction of Hepatitis C Virus (HCV) Infection Relapse in Nonresponders to Primary Interferon Therapy by means of HCV RNA Whole-Blood Analysis

2004 ◽  
Vol 39 (12) ◽  
pp. 1754-1760 ◽  
Author(s):  
T. Watkins-Riedel ◽  
P. Ferenci ◽  
P. Steindl-Munda ◽  
M. Gschwantler ◽  
C. Mueller ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Whole Blood ◽  
Interferon Therapy ◽  
Hcv Infection ◽  
Blood Analysis ◽  
Hcv Rna ◽  
Early Prediction ◽  
Whole Blood Analysis
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