Emerging oral disease-modifying therapies in multiple sclerosis: a review of the latest clinical evidence

2011 ◽  
Vol 1 (7) ◽  
pp. 1049-1058
Author(s):  
Esther V Hobson ◽  
Basil Sharrack
Keyword(s):  
Multiple Sclerosis ◽  
Clinical Evidence ◽  
Oral Disease ◽  
Disease Modifying Therapies ◽  
Disease Modifying

scholarly journals Adherence to Glatiramer Acetate 40 Mg Versus Oral Disease-Modifying Therapies for Multiple Sclerosis

2015 ◽  
Vol 18 (7) ◽  
pp. A766 ◽  
Author(s):  
R Halpern ◽  
R Wolbeck ◽  
C Blauer-Peterson ◽  
Y Wu ◽  
SK Gandhi
Keyword(s):  
Multiple Sclerosis ◽  
Glatiramer Acetate ◽  
Oral Disease ◽  
Disease Modifying Therapies ◽  
Disease Modifying

The Use of Oral Disease-Modifying Therapies in Multiple Sclerosis

2016 ◽  
Vol 16 (4) ◽  
Author(s):  
Benedikt Kretzschmar ◽  
Hannah Pellkofer ◽  
Martin S. Weber
Keyword(s):  
Multiple Sclerosis ◽  
Oral Disease ◽  
Disease Modifying Therapies ◽  
Disease Modifying

Use of the new oral disease-modifying therapies for multiple sclerosis in British Columbia, Canada: the first five-years

2018 ◽  
Vol 25 ◽  
pp. 57-60 ◽  
Author(s):  
Solmaz Setayeshgar ◽  
Elaine Kingwell ◽  
Feng Zhu ◽  
Xinyu Zhang ◽  
Tingting Zhang ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
British Columbia ◽  
Oral Disease ◽  
Disease Modifying Therapies ◽  
Disease Modifying

scholarly journals Efficacy and tolerability of oral versus injectable disease-modifying therapies for multiple sclerosis in clinical practice

2016 ◽  
Vol 2 ◽  
pp. 205521731667786 ◽  
Author(s):  
Erin E Longbrake ◽  
Anne H Cross ◽  
Amber Salter
Keyword(s):  
Multiple Sclerosis ◽  
Clinical Practice ◽  
Proportional Hazards ◽  
Dimethyl Fumarate ◽  
Cox Proportional Hazards ◽  
Oral Disease ◽  
Sensitivity Analyses ◽  
Drug Discontinuation ◽  
Disease Modifying Therapies ◽  
Disease Modifying

Background The advent of oral disease-modifying therapies fundamentally changed the treatment of multiple sclerosis. Nevertheless, impressions of their relative efficacy and tolerability are primarily founded on expert opinion. Objective The purpose of this study was to determine whether oral disease-modifying therapies were better tolerated and/or more effective for controlling multiple sclerosis compared to injectable therapies in clinical practice. Methods Single-center, retrospective cohort study. 480 patients initiated oral (fingolimod, teriflunomide, or dimethyl fumarate) or injectable therapy between March 2013–March 2015 and follow-up data was collected for 5–31 months. Outcomes included on-drug multiple sclerosis activity and drug discontinuation. Cox proportional hazards models were used to control for baseline differences and sensitivity analyses using propensity-weighted matching were performed. Results A higher proportion of teriflunomide-treated patients experienced multiple sclerosis activity compared to those treated with injectable therapies ( p = 0.0053) in the adjusted model. Breakthrough multiple sclerosis was equally prevalent among fingolimod and dimethyl fumarate-treated compared to injectable therapy-treated patients. Of patients initiating a disease-modifying therapy, 32–46% discontinued or switched treatments during the study. After controlling for baseline differences, discontinuation rates were comparable across treatment groups. Conclusions In this cohort, oral and injectable disease-modifying therapies were equally well tolerated, but teriflunomide appeared less effective for controlling multiple sclerosis activity than injectable therapies. Further study is needed.

Persistence and adherence to the new oral disease-modifying therapies for multiple sclerosis: A population-based study

2019 ◽  
Vol 27 ◽  
pp. 364-369 ◽  
Author(s):  
Solmaz Setayeshgar ◽  
Elaine Kingwell ◽  
Feng Zhu ◽  
Tingting Zhang ◽  
Robert Carruthers ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Population Based ◽  
Oral Disease ◽  
Population Based Study ◽  
Disease Modifying Therapies ◽  
Disease Modifying
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