ROLE OF INTRAVENOUS INSULIN THERAPY IN CRITICALLY ILL PATIENTS

2004 ◽  
Vol 10 (Supplement 2) ◽  
pp. 17-20 ◽  
Author(s):  
Greet H. Van den Berghe
Keyword(s):  
Insulin Therapy ◽  
Critically Ill ◽  
Critically Ill Patients ◽  
Intravenous Insulin

The Role of Insulin Therapy in Critically Ill Patients

2005 ◽  
Vol 4 (6) ◽  
pp. 353-360 ◽  
Author(s):  
Lies Langouche ◽  
Ilse Vanhorebeek ◽  
Greet Van den Berghe
Keyword(s):  
Insulin Therapy ◽  
Critically Ill ◽  
Critically Ill Patients

scholarly journals Glucose Management Technologies for the Critically Ill

2019 ◽  
Vol 13 (4) ◽  
pp. 682-690 ◽  
Author(s):  
Pedro D. Salinas ◽  
Carlos E. Mendez
Keyword(s):  
Insulin Therapy ◽  
Critically Ill ◽  
Critically Ill Patients ◽  
New Technologies ◽  
Point Of Care ◽  
Glucose Monitoring ◽  
Standard Of Care ◽  
Optimal Method ◽  
Intravenous Insulin ◽  
Glucose Management

Hyperglycemia is common in the intensive care unit (ICU) both in patients with and without a previous diagnosis of diabetes. The optimal glucose range in the ICU population is still a matter of debate. Given the risk of hypoglycemia associated with intensive insulin therapy, current recommendations include treating hyperglycemia after two consecutive glucose >180 mg/dL with target levels of 140-180 mg/dL for most patients. The optimal method of sampling glucose and delivery of insulin in critically ill patients remains elusive. While point of care glucose meters are not consistently accurate and have to be used with caution, continuous glucose monitoring (CGM) is not standard of care, nor is it generally recommended for inpatient use. Intravenous insulin therapy using paper or electronic protocols remains the preferred approach for critically ill patients. The advent of new technologies, such as electronic glucose management, CGM, and closed-loop systems, promises to improve inpatient glycemic control in the critically ill with lower rates of hypoglycemia.

Improved safety with intravenous insulin therapy for critically ill patients with renal failure

Nutrition ◽  
2014 ◽  
Vol 30 (5) ◽  
pp. 557-562 ◽  
Author(s):  
Roland N. Dickerson ◽  
Allison M. Lynch ◽  
George O. Maish ◽  
Martin A. Croce ◽  
Gayle Minard ◽  
...  
Keyword(s):  
Renal Failure ◽  
Insulin Therapy ◽  
Critically Ill ◽  
Critically Ill Patients ◽  
Intravenous Insulin

Effect of Intravenous Insulin Therapy on Clinical Outcomes in Critically Ill Patients

2007 ◽  
Vol 333 (6) ◽  
pp. 354-361 ◽  
Author(s):  
Saad A. Hafidh ◽  
Matthew D. Reuter ◽  
Loren J. Chassels ◽  
Sangita Aradhyula ◽  
Saqib S. Bhutto ◽  
...  
Keyword(s):  
Insulin Therapy ◽  
Clinical Outcomes ◽  
Critically Ill ◽  
Critically Ill Patients ◽  
Intravenous Insulin

scholarly journals Serum Procalcitonin Level and Mortality Risk in Critically ill Patients with Ventilator-Associated Pneumonia

2015 ◽  
Vol 37 (5) ◽  
pp. 1967-1972 ◽  
Author(s):  
Bo Li ◽  
Xin Zhao ◽  
Shumei Li
Keyword(s):  
Critically Ill ◽  
Mortality Risk ◽  
Critically Ill Patients ◽  
Cox Regression ◽  
High Serum ◽  
Ventilator Associated Pneumonia ◽  
Prognostic Role ◽  
Procalcitonin Level ◽  
Increased Risk

Background/Aims: The prognostic role of serum procalcitonin level in critically ill patients with ventilator-associated pneumonia was unclear. The aim of our study was to investigate the relationship between serum procalcitonin level and mortality risk in critically ill patients with ventilator-associated pneumonia. Methods: Data of critically ill patients with ventilator-associated pneumonia were retrospectively collected. Demographics, comorbidities, and serum procalcitonin level were extracted from electronic medical records. The primary outcome was mortality within two months after diagnosis. Multivariable Cox regression analyses were performed to assess the prognostic role of serum procalcitonin level in those patients. Results: A total of 115 critically ill patients with ventilator-associated pneumonia were enrolled in our study. Serum procalcitonin level was not associated with age, gender, or other comorbidities. Univariate Cox regression model showed that high serum procalcitonin level was associated increased risk of morality within 2 months after diagnosis (OR = 2.32, 95% CI 1.25-4.31, P = 0.008). Multivariable Cox regression model showed that high serum procalcitonin level was independently associated increased risk of morality within 2 months after diagnosis (OR = 2.38, 95% CI 1.26-4.50, P = 0.008). Conclusion: High serum procalcitonin level is an independent prognostic biomarker of mortality risk in critically ill patients with ventilator-associated pneumonia, and it's a promising biomarker of prognosis in critically ill patients.

scholarly journals Do Aspirin and Other Antiplatelet Drugs Reduce the Mortality in Critically Ill Patients?

Thrombosis ◽  
2012 ◽  
Vol 2012 ◽  
pp. 1-8 ◽  
Author(s):  
Wolfgang Lösche ◽  
Janina Boettel ◽  
Björn Kabisch ◽  
Johannes Winning ◽  
Ralf A. Claus ◽  
...  
Keyword(s):  
Organ Failure ◽  
Critically Ill ◽  
Critically Ill Patients ◽  
Therapeutic Option ◽  
Bleeding Risk ◽  
Antiplatelet Drugs ◽  
Beneficial Effects ◽  
Prospective Trials ◽  
High Bleeding Risk

Platelet activation has been implicated in microvascular thrombosis and organ failure in critically ill patients. In the first part the present paper summarises important data on the role of platelets in systemic inflammation and sepsis as well as on the beneficial effects of antiplatelet drugs in animal models of sepsis. In the second part the data of retrospective and prospective observational clinical studies on the effect of aspirin and other antiplatelet drugs in critically ill patients are reviewed. All of these studies have shown that aspirin and other antiplatelet drugs may reduce organ failure and mortality in these patients, even in case of high bleeding risk. From the data reviewed here interventional prospective trials are needed to test whether aspirin and other antiplatelet drugs might offer a novel therapeutic option to prevent organ failure in critically ill patients.

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