scholarly journals Cellular Targets of the SV40 Small-t Antigen in Human Cell Transformation

Cell Cycle ◽  
2004 ◽  
Vol 3 (5) ◽  
pp. 604-608 ◽  
Author(s):  
Christine Skoczylas ◽  
Kelly M. Fahrbach ◽  
Kathleen Rundell
Keyword(s):  
Human Cell ◽  
Cell Transformation ◽  
T Antigen ◽  
Cellular Targets ◽  
Small T Antigen ◽  
Sv40 Small T

scholarly journals Critical Role for SV40 Small-t Antigen in Human Cell Transformation

Virology ◽  
2001 ◽  
Vol 290 (2) ◽  
pp. 192-198 ◽  
Author(s):  
Jing Yu ◽  
Anita Boyapati ◽  
Kathleen Rundell
Keyword(s):  
Human Cell ◽  
Cell Transformation ◽  
Critical Role ◽  
T Antigen ◽  
Small T Antigen ◽  
Sv40 Small T

scholarly journals STRIPAK directs PP2A activity toward MAP4K4 to promote oncogenic transformation of human cells

eLife ◽  
2020 ◽  
Vol 9 ◽  
Author(s):  
Jong Wook Kim ◽  
Christian Berrios ◽  
Miju Kim ◽  
Amy E Schade ◽  
Guillaume Adelmant ◽  
...  
Keyword(s):  
Cell Transformation ◽  
Hippo Pathway ◽  
T Antigen ◽  
Subunit Interactions ◽  
C Subunit ◽  
B Subunits ◽  
Small T Antigen ◽  
Sv40 Small T ◽  
The Hippo Pathway

Alterations involving serine-threonine phosphatase PP2A subunits occur in a range of human cancers, and partial loss of PP2A function contributes to cell transformation. Displacement of regulatory B subunits by the SV40 Small T antigen (ST) or mutation/deletion of PP2A subunits alters the abundance and types of PP2A complexes in cells, leading to transformation. Here, we show that ST not only displaces common PP2A B subunits but also promotes A-C subunit interactions with alternative B subunits (B’’’, striatins) that are components of the Striatin-interacting phosphatase and kinase (STRIPAK) complex. We found that STRN4, a member of STRIPAK, is associated with ST and is required for ST-PP2A-induced cell transformation. ST recruitment of STRIPAK facilitates PP2A-mediated dephosphorylation of MAP4K4 and induces cell transformation through the activation of the Hippo pathway effector YAP1. These observations identify an unanticipated role of MAP4K4 in transformation and show that the STRIPAK complex regulates PP2A specificity and activity.

SV40 small T antigen and PP2A phosphatase in cell transformation

2008 ◽  
Vol 27 (2) ◽  
pp. 137-146 ◽  
Author(s):  
Anna A. Sablina ◽  
William C. Hahn
Keyword(s):  
Cell Transformation ◽  
T Antigen ◽  
Small T Antigen ◽  
Sv40 Small T

scholarly journals STRIPAK directs PP2A activity toward MAP4K4 to promote oncogenic transformation

2019 ◽  
Author(s):  
Jong Wook Kim ◽  
Christian Berrios ◽  
Miju Kim ◽  
Amy E. Schade ◽  
Guillaume Adelmant ◽  
...  
Keyword(s):  
Cell Transformation ◽  
Hippo Pathway ◽  
T Antigen ◽  
Subunit Interactions ◽  
C Subunit ◽  
B Subunits ◽  
Small T Antigen ◽  
Sv40 Small T ◽  
The Hippo Pathway

AbstractAlterations involving serine-threonine phosphatase PP2A subunits occur in a range of human cancers and partial loss of PP2A function contributes to cell transformation. Displacement of regulatory B subunits by the SV40 Small T antigen (ST) or mutation/deletion of PP2A subunits alters the abundance and types of PP2A complexes in cells, leading to transformation. Here we show that ST not only displaces common PP2A B subunits but also promotes A-C subunit interactions with alternative B subunits (B’’’, striatins) that are components of the Striatin-interacting phosphatase and kinase (STRIPAK) complex. We found that STRN4, a member of STRIPAK, is associated with ST and is required for ST-PP2A-induced cell transformation. ST recruitment of STRIPAK facilitates PP2A-mediated dephosphorylation of MAP4K4 and induces cell transformation through the activation of the Hippo pathway effector YAP1. These observations identify an unanticipated role of MAP4K4 in transformation and show that the STRIPAK complex regulates PP2A specificity and activity.

SV40 small t antigen enhances the transformation activity of limiting concentrations of SV40 large T antigen

Cell ◽  
1987 ◽  
Vol 48 (2) ◽  
pp. 321-330 ◽  
Author(s):  
Ilan Bikel ◽  
Ximena Montano ◽  
Mounzer E. Agha ◽  
Myles Brown ◽  
Melissa McCormack ◽  
...  
Keyword(s):  
T Antigen ◽  
Large T Antigen ◽  
Sv40 Large T Antigen ◽  
Transformation Activity ◽  
Small T Antigen ◽  
Sv40 Small T

A fail-safe system to prevent oncogenesis by senescence is targeted by SV40 small T antigen

Oncogene ◽  
2019 ◽  
Vol 39 (10) ◽  
pp. 2170-2186 ◽  
Author(s):  
Kiyotaka Oshikawa ◽  
Masaki Matsumoto ◽  
Manabu Kodama ◽  
Hideyuki Shimizu ◽  
Keiichi I. Nakayama
Keyword(s):  
T Antigen ◽  
Small T Antigen ◽  
Fail Safe ◽  
Sv40 Small T

SV40 Small T Antigen Enhances Progression to >G2 during Lytic Infection

1999 ◽  
Vol 251 (1) ◽  
pp. 121-127 ◽  
Author(s):  
Brian Whalen ◽  
Judith Laffin ◽  
Thomas D. Friedrich ◽  
John M. Lehman
Keyword(s):  
T Antigen ◽  
Lytic Infection ◽  
Small T Antigen ◽  
Sv40 Small T

Hepatic Expression of SV40 Small-t Antigen Blocks the in Vivo CD95-Mediated Apoptosis

2001 ◽  
Vol 284 (2) ◽  
pp. 369-376 ◽  
Author(s):  
Raphaëlle Gillet ◽  
Catherine Cavard ◽  
Gisèle Grimber ◽  
Pascale Briand ◽  
Virginie Joulin
Keyword(s):  
T Antigen ◽  
Hepatic Expression ◽  
Small T Antigen ◽  
Sv40 Small T
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