scholarly journals The role of non-canonical SNAREs in synaptic vesicle recycling

2012 ◽  
Vol 2 (1) ◽  
pp. 20-27 ◽  
Author(s):  
Denise M.O. Ramirez ◽  
Ege T. Kavalali
Keyword(s):  
Synaptic Vesicle ◽  
Synaptic Vesicle Recycling ◽  
Vesicle Recycling

scholarly journals Essential Role of Phosphoinositide Metabolism in Synaptic Vesicle Recycling

Cell ◽  
1999 ◽  
Vol 99 (2) ◽  
pp. 179-188 ◽  
Author(s):  
Ottavio Cremona ◽  
Gilbert Di Paolo ◽  
Markus R Wenk ◽  
Anita Lüthi ◽  
Warren T Kim ◽  
...  
Keyword(s):  
Synaptic Vesicle ◽  
Essential Role ◽  
Phosphoinositide Metabolism ◽  
Synaptic Vesicle Recycling ◽  
Vesicle Recycling

Key role of clathrin-mediated endocytosis in synaptic vesicle recycling

2007 ◽  
Vol 39 (4-5) ◽  
pp. 339-340
Author(s):  
Y. Tsytsyura ◽  
N. Glyvuk ◽  
M. Krikunova ◽  
N. Jung ◽  
V. Haucke ◽  
...  
Keyword(s):  
Synaptic Vesicle ◽  
Synaptic Vesicle Recycling ◽  
Vesicle Recycling

scholarly journals The Role of Mitochondrially Derived ATP in Synaptic Vesicle Recycling

2015 ◽  
Vol 290 (37) ◽  
pp. 22325-22336 ◽  
Author(s):  
Divya Pathak ◽  
Lauren Y. Shields ◽  
Bryce A. Mendelsohn ◽  
Dominik Haddad ◽  
Wei Lin ◽  
...  
Keyword(s):  
Synaptic Vesicle ◽  
Synaptic Vesicle Recycling ◽  
Vesicle Recycling

scholarly journals Caenorhabditis elegans Intersectin: A Synaptic Protein Regulating Neurotransmission

2007 ◽  
Vol 18 (12) ◽  
pp. 5091-5099 ◽  
Author(s):  
Simon Rose ◽  
Maria Grazia Malabarba ◽  
Claudia Krag ◽  
Anna Schultz ◽  
Hanako Tsushima ◽  
...  
Keyword(s):  
Caenorhabditis Elegans ◽  
Synaptic Vesicle ◽  
Regulatory Role ◽  
Actin Dynamics ◽  
Synaptic Vesicle Recycling ◽  
Multifunctional Protein ◽  
C Elegans ◽  
Vesicle Recycling ◽  
Negative Regulatory Role

Intersectin is a multifunctional protein that interacts with components of the endocytic and exocytic pathways, and it is also involved in the control of actin dynamics. Drosophila intersectin is required for viability, synaptic development, and synaptic vesicle recycling. Here, we report the characterization of intersectin function in Caenorhabditis elegans. Nematode intersectin (ITSN-1) is expressed in the nervous system, and it is enriched in presynaptic regions. The C. elegans intersectin gene (itsn-1) is nonessential for viability. In addition, itsn-1-null worms do not display any evident phenotype, under physiological conditions. However, they display aldicarb-hypersensitivity, compatible with a negative regulatory role of ITSN-1 on neurotransmission. ITSN-1 physically interacts with dynamin and EHS-1, two proteins involved in synaptic vesicle recycling. We have previously shown that EHS-1 is a positive modulator of synaptic vesicle recycling in the nematode, likely through modulation of dynamin or dynamin-controlled pathways. Here, we show that ITSN-1 and EHS-1 have opposite effects on aldicarb sensitivity, and on dynamin-dependent phenotypes. Thus, the sum of our results identifies dynamin, or a dynamin-controlled pathway, as a potential target for the negative regulatory role of ITSN-1.

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