scholarly journals In vitro selected RNA aptamer recognizing glutathione induces ROS mediated apoptosis in the human breast cancer cell line MCF 7

RNA Biology ◽  
2011 ◽  
Vol 8 (1) ◽  
pp. 101-111 ◽  
Author(s):  
Jyoti Bala ◽  
Ashima Bhaskar ◽  
Akhil Varshney ◽  
Abhay Kumar Singh ◽  
Sharmistha Dey ◽  
...  
2011 ◽  
Vol 26 (1) ◽  
pp. 105-111 ◽  
Author(s):  
Ayfer Yurt Kilcar ◽  
F. Zumrut Biber Muftuler ◽  
Perihan Unak ◽  
Cigir Biray Avci ◽  
Cumhur Gunduz

2000 ◽  
Vol 7 (3) ◽  
pp. 121-128 ◽  
Author(s):  
Nikhil Gokhale ◽  
Subhash Padhye ◽  
Chris Newton ◽  
Robin Pritchard

The C-3 substituted phenylazo derivatives of lawsone (2-hydroxy-l,4 p-naphthoquinone, III) were synthesized and characterized. The X-ray crystal structure was determined for the ligand 3-(3′-methyl phenylazo) lawsone. The copper complexes of these derivatives were found to possess 1:2 metal stoichiometry and square planar geometries with intermolecular stackings, resulting in antiferromagnetic exchange interactions. The in vitro activity of all the synthesized compounds was examined against human breast cancer cell-line, MCF-7, which revealed enhanced activities for the metal complexes, the highest activity being observed for the copper compound of 3-(3′-methyl phenylazo) lawsone.


2014 ◽  
Vol 21 (9) ◽  
pp. 1160-1170 ◽  
Author(s):  
Dharmendra Yadav ◽  
Komal Kalani ◽  
Abhishek Singh ◽  
Feroz Khan ◽  
Santosh Srivastava ◽  
...  

1992 ◽  
Vol 292 (1) ◽  
pp. 136-140 ◽  
Author(s):  
Ryuji Kitamura ◽  
Keiko Sato ◽  
Minoru Sawada ◽  
Susumu Itoh ◽  
Mitsukazu Kitada ◽  
...  

2002 ◽  
Vol 129 (1-2) ◽  
pp. 55-63 ◽  
Author(s):  
Christel M Olsen ◽  
Elise T.M Meussen-Elholm ◽  
Jørn A Holme ◽  
Jan K Hongslo

2021 ◽  
Vol 66 (1) ◽  
pp. 65-71
Author(s):  
Hung Nguyen Phi ◽  
Toan Tran Quoc ◽  
Tuan Nguyen Anh ◽  
Vy Trinh Ngoc Thao ◽  
Yen Ngo Thi Ngoc ◽  
...  

Three alkaloids (named rutaecarpine (1), evodiamine (2), schinifoline (3) and one phenylpropanoid, integrifoliodiol (4)) have been isolated from the EtOAc extract of the fruits of Tetradium ruticarpum (A. Juss.) T. G. Hartley collected in Lang Son province. Their structures have been identified by using 1D and 2D NMR spectroscopies. All four compounds were tested for their cytotoxicity against the human breast cancer cell line (MCF-7) and tamoxifen-resistant breast cancer cell line (MCF\TAMR). The results showed that rutaecarpine (1) inhibited the growth of MCF7 and MCF\TAMR with its IC50 values of 41.2 and 64.6 µM, respectively. In addition, compounds 1, 2, and 4 showed moderate activity toward MCF-7 cell line.


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