scholarly journals Clinicopathologic Characteristics of Patients Who Underwent Curative Additional Gastrectomy after Endoscopic Submucosal Dissection for Early Gastric Cancer or Adenoma

2012 ◽  
Vol 59 (4) ◽  
pp. 289 ◽  
Author(s):  
Hyejin Noh ◽  
Jong-Jae Park ◽  
Jae-Won Yun ◽  
Minjung Kwon ◽  
Dae Woong Yoon ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Early Gastric Cancer ◽  
Endoscopic Submucosal Dissection ◽  
Clinicopathologic Characteristics ◽  
Submucosal Dissection ◽  
Additional Gastrectomy

scholarly journals Is Additional Gastrectomy Required for Elderly Patients after Endoscopic Submucosal Dissection with Endoscopic Curability C-2 for Early Gastric Cancer?

Digestion ◽  
2021 ◽  
pp. 1-9
Author(s):  
Waku Hatta ◽  
Takuji Gotoda ◽  
Tomoyuki Koike ◽  
Kaname Uno ◽  
Naoki Asano ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Early Gastric Cancer ◽  
Risk Stratification ◽  
Elderly Patients ◽  
Endoscopic Submucosal Dissection ◽  
Submucosal Dissection ◽  
All Cause Mortality ◽  
Specific Mortality ◽  
Cancer Specific Mortality ◽  
Additional Gastrectomy

<b><i>Background:</i></b> With the ongoing growth of the aged population, the number of elderly patients suffering from gastric cancer has increased in Japan. Since the frequency of lymph node metastasis (LNM) in patients after endoscopic submucosal dissection (ESD) with endoscopic curability (eCura) C-2 for early gastric cancer (EGC) is relative low, the following question can be raised: “Is additional gastrectomy required for elderly patients with such criteria for ESD?” <b><i>Summary:</i></b> For therapeutic decision-making after ESD with eCura C-2, the risk of all-cause mortality and impaired quality of life (QoL) should thus be evaluated. Risk stratification of LNM and gastric cancer-specific mortality was established by the eCura system; however, it remains unclear how much these categories and treatment selection affect all-cause mortality. The contribution of prognostic tools for predicting all-cause mortality was noted to vary across the studies of patients with EGC; thus, further studies that investigate comprehensive geriatric assessment (CGA) may be required. Regarding the QoL, studies on elderly patients remain to be lacking. Furthermore, one of the issues with CGA and QoL tools is that they are time consuming. <b><i>Key Messages:</i></b> Combined evaluation of risk stratification of gastric cancer-specific mortality by the eCura system and risk of nongastric cancer-related mortality and impaired QoL may be the current optimal method to decide treatment strategy after ESD with eCura C-2 for EGC among elderly patients. A large-scale prospective study that investigates CGA domains is required to identify predictors of all-cause mortality and impaired QoL, and a more easily usable tool should be developed.

Clinicopathologic Characteristics and Outcomes of Early Gastric Cancer Treated with Endoscopic Submucosal Dissection at the gastric angle

2020 ◽  
Author(s):  
Qiaoyan Wu ◽  
Haizhong Jiang ◽  
Shuanglin Xie ◽  
Xiaoyun Ding
Keyword(s):  
Gastric Cancer ◽  
Early Gastric Cancer ◽  
Endoscopic Submucosal Dissection ◽  
Chinese Patients ◽  
Gastric Body ◽  
Anatomic Site ◽  
Clinicopathologic Characteristics ◽  
Submucosal Dissection ◽  
Common Location ◽  
Submucosal Fibrosis

Abstract BackgroundNone studies have been reported focused on Early gastric cancer(EGC) at the gastric angle although EGCs have been commonly found in this region in Chinese patients. We attempted to discover the characteristics of EGC patients treated Endoscopic submucosal dissection(ESD) at the gastric angle that have not yet to be reported.METHODS We reviewed the medical records of patients with EGC treated with ESD from January 2010 to December 2018, and investigated and analyzed clinicopathologic features and ESD outcomes of EGC patients.RESULTSIn all 444 EGC patients receiving ESD treatment, the second most common anatomic site was the gastric angle (23.0%), following the gastric antrum (55.6%). Compared to the other gastric parts, the EGC at the gastric angle had a relatively higher percentage of the flat or depressed lesions (67.7%)( P=0.05) . The rate of severe submucosal fibrosis was significantly higher in the gastric angle lesions(15.69%) than those in the gastric body (4.5%) ,cardia (3.9% ),antrum (1.21%) (P < 0.001) .Among EGCs at the gastric angle there were lower rates of en bloc resection , complete resection and curative resection , as well as higher perforation rate and longer procedure time in the severe submucosal fibrosis group (P<0.05) .CONCLUSIONSThe gastric angle is the second most common location of EGCs resected with ESD.There is a higher rate of severe submucosal fibrosis in EGCs at the gastric angle ,which suggests more attention should be paid to patients with EGCs at the gastric angle referred for ESD.

scholarly journals Clinicopathologic characteristics and resection rates of papillary early gastric cancer removed by endoscopic submucosal dissection

2017 ◽  
Vol 1 ◽  
pp. 11-15 ◽  
Author(s):  
Katarzyna Karpińska-Kaczmarczyk ◽  
Magdalena Lewandowska ◽  
Andrzej Białek ◽  
Małgorzata Ławniczak ◽  
Ewa Dobak ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Early Gastric Cancer ◽  
Endoscopic Submucosal Dissection ◽  
Clinicopathologic Characteristics ◽  
Submucosal Dissection

scholarly journals Favorable Long-Term Outcomes of Endoscopic Submucosal Dissection for Differentiated-Type-Predominant Early Gastric Cancer with Histological Heterogeneity

2020 ◽  
Vol 9 (4) ◽  
pp. 1064
Author(s):  
Tae-Se Kim ◽  
Hyeong Chan Shin ◽  
Byung-Hoon Min ◽  
Kyoung-Mee Kim ◽  
Yang Won Min ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Early Gastric Cancer ◽  
Endoscopic Submucosal Dissection ◽  
Curative Resection ◽  
Regional Lymph Node ◽  
Long Term Outcomes ◽  
Clinicopathologic Characteristics ◽  
Submucosal Dissection ◽  
Histological Heterogeneity

It remains unclear whether endoscopic submucosal dissection (ESD) can be indicated for differentiated-type-predominant early gastric cancer mixed with a minor undifferentiated component (EGC with histological heterogeneity (HH)). Here, we reviewed and compared clinicopathologic characteristics and long-term outcomes of ESD of 257 patients with EGC-HH and those of 2386 patients with pure differentiated-type EGC (PuD-EGC). After ESD, EGC-HH was managed in the same way as PuD-EGC. EGC-HHs were significantly associated with larger tumor size, more frequent submucosal invasion, and lymphovascular invasion compared to PuD-EGCs. Despite these aggressive features of EGC-HH, no local recurrence or gastric cancer-related death occurred during a median of 58 months of follow up after ESD for EGC-HH, if curative resection was achieved. After curative ESD for EGC-HH, six patients had metachronous recurrence (5.0%) and one patient underwent extragastric recurrence in a regional lymph node (0.8%). All these recurrence cases were curatively treated with ESD or gastrectomy. For patients with EGC-HH, five-year overall survival and recurrence-free survival rates after curative ESD were 97.0% and 94.8%, respectively, which were comparable to those of patients with PuD-EGC. In conclusion, ESD showed favorable long-term outcomes after curative resection and may be an acceptable treatment option for EGC-HH meeting curative endoscopic resection criteria.

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