Single Nucleotide Polymorphisms of BMP15 are Associated with Poor Ovarian Response in In Vitro Fertilization Programs

2015 ◽  
Vol 03 (04) ◽  
Author(s):  
Rosa Vanyan ◽  
Nataliya Dolgushina ◽  
Andrey Donnikov
Keyword(s):  
In Vitro Fertilization ◽  
Single Nucleotide Polymorphisms ◽  
Ovarian Response ◽  
Nucleotide Polymorphisms ◽  
Poor Ovarian Response ◽  
Single Nucleotide ◽  
Vitro Fertilization

scholarly journals Association of single-nucleotide polymorphisms in the ESR2 and FSHR genes with poor ovarian response in infertile Jordanian women

2021 ◽  
Vol 48 (1) ◽  
pp. 69-79
Author(s):  
Amer Mahmoud Sindiani ◽  
Osamah Batiha ◽  
Esra’a Al-zoubi ◽  
Sara Khadrawi ◽  
Ghadeer Alsoukhni ◽  
...  
Keyword(s):  
Single Nucleotide Polymorphisms ◽  
Statistical Significance ◽  
Ovarian Response ◽  
Control Group ◽  
P Value ◽  
Case Group ◽  
Nucleotide Polymorphisms ◽  
Poor Ovarian Response ◽  
Single Nucleotide ◽  
Number Of Patients

Objective: Poor ovarian response (POR) refers to a subnormal follicular response that leads to a decrease in the quality and quantity of the eggs retrieved after ovarian stimulation during assisted reproductive treatment (ART). The present study investigated the associations of multiple variants of the estrogen receptor 2 (ESR2) and follicle-stimulating hormone receptor (FSHR) genes with POR in infertile Jordanian women undergoing ART.Methods: Four polymorphisms, namely ESR2 rs1256049, ESR2 rs4986938, FSHR rs6165, and FSHR rs6166, were investigated in 60 infertile Jordanian women undergoing ART (the case group) and 60 age-matched fertile women (the control group), with a mean age of 33.60±6.34 years. Single-nucleotide polymorphisms (SNPs) were detected by restriction fragment length polymorphism and then validated using Sanger sequencing.Results: The p-value of the difference between the case and control groups regarding FSHR rs6166 was very close to 0.05 (p=0.054). However, no significant differences were observed between the two groups in terms of the other three SNPs, namely ESR2 rs1256049, ESR2 rs4986938, and FSHR rs6165 (p=0.561, p=0.433, and p=0.696, respectively).Conclusion: The association between FSHR rs6166 and POR was not statistically meaningful in the present study, but the near-significant result of this experiment suggests that statistical significance might be found in a future study with a larger number of patients.

scholarly journals Poor ovarian response in women undergoing in vitro fertilization is associated with altered microRNA expression in cumulus cells

2015 ◽  
Vol 103 (6) ◽  
pp. 1469-1476.e3 ◽  
Author(s):  
Cengiz Karakaya ◽  
Ozlem Guzeloglu-Kayisli ◽  
Asli Uyar ◽  
Amanda N. Kallen ◽  
Elnur Babayev ◽  
...  
Keyword(s):  
In Vitro Fertilization ◽  
Ovarian Response ◽  
Cumulus Cells ◽  
Microrna Expression ◽  
Poor Ovarian Response ◽  
Vitro Fertilization

scholarly journals Serum anti-Müllerian hormone level as a predictor of poor ovarian response in in vitro fertilization patients

2010 ◽  
Vol 10 (1) ◽  
pp. 9-14 ◽  
Author(s):  
Sezai Sahmay ◽  
Meral Cetin ◽  
Pelin Ocal ◽  
Semih Kaleli ◽  
Hulya Senol ◽  
...  
Keyword(s):  
In Vitro Fertilization ◽  
Hormone Level ◽  
Ovarian Response ◽  
Poor Ovarian Response ◽  
Vitro Fertilization
Sign in / Sign up

Export Citation Format

Share Document