scholarly journals Airway Pressure Release Ventilation and High-Frequency Oscillatory Ventilation: Potential Strategies to Treat Severe Hypoxemia and Prevent Ventilator-Induced Lung Injury

2015 ◽  
Vol 60 (10) ◽  
pp. 1509-1521 ◽  
Author(s):  
F. Facchin ◽  
E. Fan
Keyword(s):  
Lung Injury ◽  
High Frequency ◽  
Airway Pressure ◽  
High Frequency Oscillatory Ventilation ◽  
Airway Pressure Release Ventilation ◽  
Severe Hypoxemia ◽  
Pressure Release ◽  
Ventilator Induced Lung Injury ◽  
Pressure Release Ventilation ◽  
High Frequency Oscillatory

scholarly journals Airway Pressure Release Ventilation Prevents Ventilator-Induced Lung Injury in Normal Lungs

JAMA Surgery ◽  
2013 ◽  
Vol 148 (11) ◽  
pp. 1005 ◽  
Author(s):  
Bryanna Emr ◽  
Louis A. Gatto ◽  
Shreyas Roy ◽  
Joshua Satalin ◽  
Auyon Ghosh ◽  
...  
Keyword(s):  
Lung Injury ◽  
Airway Pressure ◽  
Airway Pressure Release Ventilation ◽  
Pressure Release ◽  
Ventilator Induced Lung Injury ◽  
Pressure Release Ventilation ◽  
Normal Lungs

HIGH FREQUENCY PERCUSSIVE VENTILATION CAN MIMIC AIRWAY PRESSURE RELEASE VENTILATION IN A TEST LUNG MODEL

2004 ◽  
Vol 32 (Supplement) ◽  
pp. A38
Author(s):  
Faera L Byerly ◽  
Bruce A Cairns ◽  
Kathy A Short ◽  
John A Haithcock ◽  
Lynn Shapiro ◽  
...  
Keyword(s):  
High Frequency ◽  
Airway Pressure ◽  
Airway Pressure Release Ventilation ◽  
Lung Model ◽  
Test Lung ◽  
Pressure Release ◽  
Pressure Release Ventilation

AIRWAY PRESSURE RELEASE VENTILATION (APRV) IN A PEDIATRIC ACUTE LUNG INJURY MODEL

1990 ◽  
Vol 18 (Supplement) ◽  
pp. S231 ◽  
Author(s):  
Lynn D. Martin ◽  
Anthony L. Bilenki ◽  
James F. Rafferty ◽  
Randall C. Wetzel
Keyword(s):  
Acute Lung Injury ◽  
Lung Injury ◽  
Airway Pressure ◽  
Airway Pressure Release Ventilation ◽  
Pressure Release ◽  
Injury Model ◽  
Lung Injury Model ◽  
Pressure Release Ventilation

Effects of Spontaneous Breathing during Airway Pressure Release Ventilation on Intestinal Blood Flow in Experimental Lung Injury

2003 ◽  
Vol 99 (5) ◽  
pp. 1137-1144 ◽  
Author(s):  
Rudolf Hering ◽  
Andreas Viehöfer ◽  
Jörg Zinserling ◽  
Hermann Wrigge ◽  
Stefan Kreyer ◽  
...  
Keyword(s):  
Blood Flow ◽  
Lung Injury ◽  
Spontaneous Breathing ◽  
Airway Pressure ◽  
Airway Pressure Release Ventilation ◽  
Intestinal Blood Flow ◽  
Systemic Hemodynamics ◽  
Blood Flows ◽  
Pressure Release ◽  
Pressure Release Ventilation

Background In critical illness, the gut is susceptible to hypoperfusion and hypoxia. Positive-pressure ventilation can affect systemic hemodynamics and regional blood flow distribution, with potentially deleterious effects on the intestinal circulation. The authors hypothesized that spontaneous breathing (SB) with airway pressure release ventilation (APRV) provides better systemic and intestinal blood flow than APRV without SB. Methods Twelve pigs with oleic acid-induced lung injury received APRV with and without SB. When SB was abolished, either the tidal volume or the ventilator rate was increased to maintain pH and arterial carbon dioxide tension constant as compared to APRV with SB. Systemic hemodynamics were determined by double indicator dilution. Blood flow to the intestinal mucosa-submucosa and muscularis-serosa was measured using colored microspheres. Results Systemic blood flow increased during APRV with SB. During APRV with SB, mucosal-submucosal blood flow (ml. g-1. min-1) was 0.39 +/- 0.21 in the stomach, 0.76 +/- 0.35 in the duodenum, 0.71 +/- 0.35 in the jejunum, 0.71 +/- 0.59 in the ileum, and 0.63 +/- 0.21 in the colon. During APRV without SB and high tidal volumes, it decreased to 0.19 +/- 0.03 in the stomach, 0.42 +/- 0.21 in the duodenum, 0.37 +/- 0.10 in the jejunum, 0.3 +/- 0.14 in the ileum, and 0.41 +/- 0.14 in the colon (P < 0.001, respectively). During APRV without SB and low tidal volumes, the respective mucosal-submucosal blood flows decreased to 0.24 +/- 0.10 (P < 0.01), 0.54 +/- 0.21 (P < 0.05), 0.48 +/- 0.17 (P < 0.01), 0.43 +/- 0.21 (P < 0.01), and 0.50 +/- 0.17 (P < 0.001) as compared to APRV with SB. Muscularis-serosal perfusion decreased during full ventilatory support with high tidal volumes in comparison with APRV with SB. Conclusion Maintaining SB during APRV was associated with better systemic and intestinal blood flows. Improvements were more pronounced in the mucosal-submucosal layer.

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