scholarly journals Polycystic Ovary Syndrome in Overweight and Normal Weight Women: The Relationships with Inflammatory Markers

2020 ◽  
Vol 5 (2) ◽  
pp. 45-51
Author(s):  
Tolga Atakul ◽  
Özgür Deniz Turan ◽  
Çiğdem Yenisey
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Inflammatory Markers ◽  
Polycystic Ovary ◽  
Normal Weight ◽  
Ovary Syndrome

The association between increased circulating irisin levels and inflammatory markers in polycystic ovary syndrome

2016 ◽  
Author(s):  
Nurdan Yildiz ◽  
Mehmet Calan ◽  
Minegul Cobanoglu ◽  
Hatice İsik Sengul ◽  
Gokcen Unal Kocabas ◽  
...  
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Inflammatory Markers ◽  
Polycystic Ovary ◽  
Ovary Syndrome

scholarly journals Polycystic ovary syndrome and circulating inflammatory markers

2017 ◽  
Vol 15 (6) ◽  
pp. 375-382 ◽  
Author(s):  
Farideh Zafari Zangeneh ◽  
Mohammad Mehdi Naghizadeh ◽  
Masoumeh Masoumi ◽  
◽  
◽  
...  
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Inflammatory Markers ◽  
Polycystic Ovary ◽  
Ovary Syndrome ◽  
Circulating Inflammatory Markers

scholarly journals Serum Testosterone to Androstenedione Ratio Predicts Metabolic Health in Normal-Weight Polycystic Ovary Syndrome Women

2021 ◽  
Author(s):  
Daniel A Dumesic ◽  
Ayli Tulberg ◽  
Megan McNamara ◽  
Tristan R Grogan ◽  
David H Abbott ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Elevated Serum ◽  
Normal Weight ◽  
Model Assessment ◽  
Metabolic Function ◽  
Ovary Syndrome ◽  
Intravenous Glucose

Abstract Context Increased aldo-keto reductase 1C3 (AKR1C3)-mediated conversion of androstenedione (A4) to testosterone (T) promotes lipid storage in subcutaneous (SC) abdominal adipose in overweight/obese polycystic ovary syndrome (PCOS) women. Objective To examine whether an elevated serum T/A4 ratio, as a marker of enhanced AKR1C3 activity in SC abdominal adipose, predicts metabolic function in normal-weight PCOS women. Design Prospective cohort study. Setting Academic center. Patients Nineteen normal-weight PCOS women; 21 age- and body mass index-matched controls. Intervention(s) Circulating hormone/metabolic determinations, intravenous glucose tolerance testing, total body dual-energy x-ray absorptiometry, SC abdominal fat biopsy. Main Outcome Measure(s) Serum T/A4 ratios, hormone/metabolic measures and AKR1C3 expression of adipocytes matured in vitro were compared between female types; serum T/A4 ratios were correlated with serum lipids, adipose insulin resistance (adipose-IR), homeostatic model assessment of insulin resistance (HOMA-IR) and insulin sensitivity (Si). Results Increased serum T/A4 ratios (P=0.040) and log adipose-IR values (P=0.002) in PCOS women versus controls were accompanied by AKR1C3 mRNA overexpression of PCOS adipocytes matured in vitro (P=0.016). Serum T/A4 ratios in PCOS women, but not controls, negatively correlated with log triglycerides (TG: R=-0.65, P=0.002) and the TG index (R=-0.57, P=0.011). Adjusting for serum free T, serum T/A4 ratios in PCOS women remained negatively correlated with log TG (R=-0.57, P=0.013) and TG index (R=-0.50, P=0.036), respectively, without significant relationships with other metabolic measures. Conclusion An elevated serum T/A4 ratio, as a marker of enhanced AKR1C3 activity in SC abdominal adipose, predicts healthy metabolic function in normal-weight PCOS women.

scholarly journals MON-223 Adipose Insulin Resistance in Normal-Weight Women with Polycystic Ovary Syndrome

2019 ◽  
Vol 3 (Supplement_1) ◽  
Author(s):  
Luis Hoyos ◽  
Karen Leung ◽  
Tristan Grogan ◽  
David Abbott ◽  
Gregorio Chazenbalk ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Normal Weight ◽  
Ovary Syndrome

scholarly journals Alarin/FSH Ratio Might Be A New Biological Marker in Polycystic Ovary Syndrome Women with Normal and Women with Obese

2019 ◽  
Vol 3 (5) ◽  
Keyword(s):  
Luteinizing Hormone ◽  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Density Lipoprotein ◽  
Biological Marker ◽  
Dehydroepiandrosterone Sulfate ◽  
Normal Weight ◽  
Control Group ◽  
Total Testosterone ◽  
Ovary Syndrome

Neuropeptides coordinate and regulate physiological processes in all animals. Alarin is a 25 amino acid neuropeptide which promotes the secretion of luteinizing hormone (LH). It has been known that serum luteinizing hormone levels are increased in women with polycystic ovary syndrome. Therefore, purpose of this was to examine the association of circulating gonadotropin secretions, and alarin with women with polycystic ovary syndrome, and to compare these findings with those of control subjects in an effort to better understand the pathophysiology of PCOS. 28 participants with a diagnosis of PCOS with normal weight and 28 participants with a diagnosis of PCOS with obese and 28 control group participants were included in this case-control study. Hormone profiles of the participants (alarin, insulin, estradiol (E2), follicle-stimulating hormone (FSH), luteinizing hormone (LH), dehydroepiandrosterone sulfate (DHEA-SO4 ), lipid profiles total testosterone, low-density lipoprotein (LDL), high-density lipoprotein (HDL), triglyceride, cholesterol) and fasting blood sugar (FBS) values were measured. Results: Serum androgens were elevated in the PCOS. Blood LH was also elevated (P < 0.05) but was higher in PCOS than Control. Patients with PCOS had an increased alarin compared with controls. LH/FSH ratio and Alarin /FSH ratio were greater than 2.1, 2.4, respectively. The blood alarin levels were significantly correlated with the serum LH levels (r=0.492, p=0.002) and the LH/FSH ratios (r=0.450, p<0.001) and Alarin/ FSH ratios. The FSH/LH and alarin /FSH ratio were elevated in the PCOS. Based on these results, the FSH/LH and Alarin /FSH ratio appears to be a useful marker of PCOS.

scholarly journals The association of dynamic thiol-disulfide homeostasis and inflammatory markers in patients with polycystic ovary syndrome

2020 ◽  
Vol 59 (1) ◽  
pp. 79-84 ◽  
Author(s):  
Gültekin Adanaş Aydın ◽  
Hilal Gülsüm Turan Özsoy ◽  
Handan Ankaralı ◽  
Gülten Özgen ◽  
Salim Neşelioğlu
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Inflammatory Markers ◽  
Polycystic Ovary ◽  
Ovary Syndrome

Oral contraceptives increase platelet microparticle levels in normal-weight women with polycystic ovary syndrome

HORMONES ◽  
2020 ◽  
Vol 19 (4) ◽  
pp. 565-571
Author(s):  
Efstathios Papadakis ◽  
Maria Sarigianni ◽  
Konstantinos Tziomalos ◽  
Georgios Mavromatidis ◽  
Dimitrios Panidis
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Oral Contraceptives ◽  
Polycystic Ovary ◽  
Normal Weight ◽  
Ovary Syndrome

scholarly journals Reproductive and metabolic determinants of granulosa cell dysfunction in normal-weight women with polycystic ovary syndrome

2018 ◽  
Vol 109 (3) ◽  
pp. 508-515 ◽  
Author(s):  
Annie A. Guedikian ◽  
Alexandria Y. Lee ◽  
Tristan R. Grogan ◽  
David H. Abbott ◽  
Karla Largaespada ◽  
...  
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Granulosa Cell ◽  
Polycystic Ovary ◽  
Normal Weight ◽  
Ovary Syndrome ◽  
Cell Dysfunction
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