The association between increased circulating irisin levels and inflammatory markers in polycystic ovary syndrome

2016 ◽  
Author(s):  
Nurdan Yildiz ◽  
Mehmet Calan ◽  
Minegul Cobanoglu ◽  
Hatice İsik Sengul ◽  
Gokcen Unal Kocabas ◽  
...  
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Inflammatory Markers ◽  
Polycystic Ovary ◽  
Ovary Syndrome

scholarly journals Polycystic ovary syndrome and circulating inflammatory markers

2017 ◽  
Vol 15 (6) ◽  
pp. 375-382 ◽  
Author(s):  
Farideh Zafari Zangeneh ◽  
Mohammad Mehdi Naghizadeh ◽  
Masoumeh Masoumi ◽  
◽  
◽  
...  
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Inflammatory Markers ◽  
Polycystic Ovary ◽  
Ovary Syndrome ◽  
Circulating Inflammatory Markers

scholarly journals The association of dynamic thiol-disulfide homeostasis and inflammatory markers in patients with polycystic ovary syndrome

2020 ◽  
Vol 59 (1) ◽  
pp. 79-84 ◽  
Author(s):  
Gültekin Adanaş Aydın ◽  
Hilal Gülsüm Turan Özsoy ◽  
Handan Ankaralı ◽  
Gülten Özgen ◽  
Salim Neşelioğlu
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Inflammatory Markers ◽  
Polycystic Ovary ◽  
Ovary Syndrome

Inflammatory markers and visceral fat are inversely associated with maximal oxygen consumption in women with polycystic ovary syndrome (PCOS)

2009 ◽  
Vol 70 (3) ◽  
pp. 394-400 ◽  
Author(s):  
Francesco Giallauria ◽  
Stefano Palomba ◽  
Ilario De Sio ◽  
Luigi Maresca ◽  
Laura Vuolo ◽  
...  
Keyword(s):  
Oxygen Consumption ◽  
Polycystic Ovary Syndrome ◽  
Visceral Fat ◽  
Inflammatory Markers ◽  
Polycystic Ovary ◽  
Maximal Oxygen Consumption ◽  
Ovary Syndrome

Weight loss and vascular inflammatory markers in overweight women with and without polycystic ovary syndrome

2012 ◽  
Vol 25 (5) ◽  
pp. 500-503 ◽  
Author(s):  
Lisa J. Moran ◽  
Manny Noakes ◽  
Gary A. Wittert ◽  
Peter M. Clifton ◽  
Robert J. Norman
Keyword(s):  
Weight Loss ◽  
Polycystic Ovary Syndrome ◽  
Inflammatory Markers ◽  
Polycystic Ovary ◽  
Ovary Syndrome ◽  
Overweight Women

scholarly journals Coagulation and Fibrinolytic Disturbances in Women with Polycystic Ovary Syndrome

2011 ◽  
Vol 96 (4) ◽  
pp. 1068-1076 ◽  
Author(s):  
Louise Mannerås-Holm ◽  
Fariba Baghaei ◽  
Göran Holm ◽  
Per Olof Janson ◽  
Claes Ohlsson ◽  
...  
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Lipid Profile ◽  
Inflammatory Markers ◽  
Polycystic Ovary ◽  
High Sensitivity ◽  
C Reactive Protein ◽  
Ovary Syndrome ◽  
Reactive Protein ◽  
High Insulin ◽  
Pai 1

Abstract Context: Studies of fibrinolysis/coagulation status in women with polycystic ovary syndrome (PCOS) are contradictory. Objectives: The aim of the study was to investigate whether women with PCOS have disturbed circulating levels of fibrinolysis/coagulation markers and, if so, whether the disturbances are related to hemodynamics, metabolic variables, sex steroids, SHBG, lipids, and inflammatory variables in women with PCOS. Design/Main Outcome Measures: Anthropometric variables, hemodynamics, circulating hemostatic and inflammatory markers, and serum lipid profile were measured in women with untreated PCOS (n = 74) and controls (n = 31). Results: After adjustments for age and body mass index (BMI), circulating plasminogen activator inhibitor 1 (PAI-1) activity and fibrinogen levels were higher in women with PCOS than controls; lipid profile, blood pressure, and levels of D-dimer, von Willebrand factor, factor VIII, tissue plasminogen activator, and inflammatory markers were comparable in the two groups. In multiple linear regression analyses including women with PCOS, low SHBG and high insulin predicted high PAI-1 activity (R2 = 0.526; P < 0.001); elevated high-sensitivity C-reactive protein and soluble E-selectin in combination with heart rate predicted high fibrinogen (R2 = 0.333; P < 0.001). Differences in PAI-1 activity were not significant after adjustments for age, BMI, SHBG, and insulin. Conclusions: PCOS is characterized by a prothrombotic state, as reflected by increased PAI-1 activity and fibrinogen, without signs of dyslipidemia or a proinflammatory state. Low SHBG and high insulin may partly explain the BMI-independent difference in PAI-1 activity between women with PCOS and controls. High-sensitivity C-reactive protein and E-selectin may be involved in regulating fibrinogen in PCOS.

scholarly journals Dietary and Physical Activity Habits in Adolescent Girls with Polycystic Ovary Syndrome (PCOS)-HAstudy

2021 ◽  
Vol 10 (16) ◽  
pp. 3469
Author(s):  
Małgorzata Mizgier ◽  
Grażyna Jarząbek-Bielecka ◽  
Dorota Formanowicz ◽  
Elżbieta Jodłowska-Siewert ◽  
Kinga Mruczyk ◽  
...  
Keyword(s):  
Physical Activity ◽  
Polycystic Ovary Syndrome ◽  
Inflammatory Markers ◽  
Leisure Time ◽  
Polycystic Ovary ◽  
Inverse Correlation ◽  
Control Group ◽  
Fasting Insulin ◽  
Ovary Syndrome ◽  
Total Fat

The role of inappropriate lifestyle in the etiology of polycystic ovary syndrome (PCOS) and its metabolic and reproductive complications has attracted much attention in recent years; however, most studies involve adult patients. Thus, the study aimed to compare dietary patterns, physical activity, metabolic, anthropometric and inflammatory markers of 14–18-year-old girls with and without PCOS (n = 61 and n = 35, respectively) as well as to assess correlations between concentrations of metabolic and inflammatory markers and macronutrient intake and to identify the independent predictors of PCOS, related to diet and physical activity (PA). Compared to the control group, PCOS girls consumed significantly more total fat (p = 0.0005), including both saturated (SFA) (p = 0.03), monounsaturated (MUFA) (p = 0.0003) and polyunsaturated fatty acids (PUFA) (p = 0.01). A significantly higher percentage of PCOS patients consumed high and medium glycemic index (GI) foods (p = 0.03) and represented a low level of PA, both during school and in leisure time (41.67 vs. 6.06%; p = 0.0001 and 32.79 vs. 5.71%; p = 0.003, respectively). The PCOS group had also significantly higher waist circumference (WC), C-reactive protein (CRP) (p = 0.01), LDL cholesterol (p = 0.01), fasting insulin (p = 0.002) and HOMA-IR (p = 0.006) levels. There was an inverse correlation between fiber intake and fasting insulin, (p = 0.0002, r = −0.37), HOMA-IR (p = 0.0004, r = −0.35), WC (p = 0.029; r = −0.222) and a positive relationship between high and medium GI diet and insulin concentration (p = 0.003; r = 0.3). An increase of 10 g/day in total fat intake per day increases the probability of PCOS by 1.4 times. If the SFA or MUFA intakes increase by 10 g, the probability of PCOS increase 1.7-fold and 2.5-fold, respectively. The consumption of foods with a medium GI raises the probability of PCOS by more than 3 times, after adjusting for age. The odds ratio decreased for the moderate and high PA at school/work and in leisure time. Further research in girls with PCOS is needed to test whether low GI and dietary fatty acid reduction combined with increased PA is effective in the nonpharmacological treatment and prevention of PCOS complications. ClinicalTrial.gov Identifier: NCT04738409.

scholarly journals Circulating inflammatory markers in polycystic ovary syndrome: a systematic review and metaanalysis

2011 ◽  
Vol 95 (3) ◽  
pp. 1048-1058.e2 ◽  
Author(s):  
Héctor F. Escobar-Morreale ◽  
Manuel Luque-Ramírez ◽  
Frank González
Keyword(s):  
Systematic Review ◽  
Polycystic Ovary Syndrome ◽  
Inflammatory Markers ◽  
Polycystic Ovary ◽  
Ovary Syndrome ◽  
Circulating Inflammatory Markers
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