scholarly journals Effects of Endogen Erythropoietin on Parathormone Secretion

2021 ◽  
Vol 2 (3) ◽  
pp. 171-174
Author(s):  
Edip Gönüllü ◽  
Sezai Özkan ◽  
Cihan Adanaş ◽  
Mehmet Fatih Özbay ◽  
Esat Kılıç ◽  
...  
Keyword(s):  
Parathormone Secretion

scholarly journals Secretion and degradation of parathormone as a function of intracellular maturation of hormone pools

1979 ◽  
Vol 83 (3) ◽  
pp. 521-528 ◽  
Author(s):  
JJ Morrissey ◽  
DV Cohn
Keyword(s):  
Cyclic Amp ◽  
Half Life ◽  
Calcium Concentration ◽  
Hormone Secretion ◽  
Ionized Calcium ◽  
Dibutyryl Cyclic Amp ◽  
Low Calcium ◽  
High Calcium ◽  
Parathormone Secretion

The biosynthesis, processing, and secretion of parthormone and the effect of calcium on these processes were measured in dispersed porcine parthyroid cells incubated with [(35)S]methionine. Proparathormone was detected at 10 min, the earliest time measured, and was rapidly and apparently quantitatively converted to parathormone. The half-life of the prohomormone pool was 15 min. Secretion of parathormone was detected by 20 min. In pulse-chase experiments there was a period between 20 and 40 min during which the wave of newly-synthesized parathormone was secreted. After 40 min during little additional radioactive hormone was secreted, but dibutyryl cyclic AMP, an agent that can mobilize stored parathormone, when added to the incubation mixtures enhanced radioactive parathormone secretion but only after 60 min, although it increased net hormone secretion as determined by radioimmunoassay to the same extent at all times studied. When the ionized calcium concentration of the medium was lowered, more radioactive hormone was secreted at all times but the effect was greatest on that hormone that was synthesized less than 60 min previously ; however, net hormone secretion in contrast to radioactive hormone was enhanced equally at all intervals. These data could mean that the refractoriness to secretion of parathormone 40-60 min of age was related to maturation of secretory container preparatory to storage. Low calcium (0.5 mM) stimulated hormone secretion up to fivefold compared to high calcium (3.0 mM) but did not affect synthesis of parathormone or proparathormne or conversion of the latter to hormone. During processing at least 70 percent of the intracellular parathormone was lost, presumably through proteolysis and this degradation was greater at high calcium. These data have been interpreted in light of the concept that two secretable pools of parathormone exist within the parathyroid.

THE ROLE OF ALDOSTERONE AND ANGIOTENSIN II IN THE REGULATION OF PARATHORMONE SECRETION

2018 ◽  
Vol 36 (Supplement 1) ◽  
pp. e78
Author(s):  
S. Prisco ◽  
L. Lenzini ◽  
P.E. Vanderriele ◽  
F. Torresan ◽  
G. Maiolino ◽  
...  
Keyword(s):  
Angiotensin Ii ◽  
Parathormone Secretion

Determinants of Parathormone Secretion in Primary Hyperparathyroidism

1989 ◽  
Vol 32 (1-3) ◽  
pp. 89-92 ◽  
Author(s):  
Michel Paillard ◽  
Jean-Paul Gardin ◽  
Pascale Borensztein ◽  
Alain Prigent
Keyword(s):  
Primary Hyperparathyroidism ◽  
Parathormone Secretion

scholarly journals Bilio-pancreatic diversion: report of a case involving bone metabolism complications

2020 ◽  
Vol 48 (11) ◽  
pp. 030006052097422
Author(s):  
Lidia Santarpia ◽  
Enza Speranza ◽  
Maria Laura Santopaolo ◽  
Maurizio Marra ◽  
Fabrizio Pasanisi
Keyword(s):  
Morbid Obesity ◽  
Vitamin D ◽  
Bone Metabolism ◽  
Vitamin D Deficiency ◽  
Young Woman ◽  
Biliopancreatic Diversion ◽  
Calcium Absorption ◽  
Pathologic Fractures ◽  
Vitamin D Levels ◽  
Parathormone Secretion

Prolonged vitamin D deficiency may result in lower calcium absorption and osteoporosis, leading to pathologic fractures. We report the case of a young woman with severe, complicated osteoporosis, which developed several years after biliopancreatic diversion that was performed to treat morbid obesity. Chronic low vitamin D levels provided a continuous stimulus for parathormone secretion, which resulted in parathyroid hyperplasia/adenoma and autonomous production of the hormone.

scholarly journals Paradoxical Block of Parathormone Secretion Is Mediated by Increased Activity of Gα Subunits

2000 ◽  
Vol 276 (9) ◽  
pp. 6763-6769 ◽  
Author(s):  
Ursula Quitterer ◽  
Michaela Hoffmann ◽  
Marc Freichel ◽  
Martin J. Lohse
Keyword(s):  
Increased Activity ◽  
Parathormone Secretion

Parathormone secretion in peritoneal dialysis patients with adynamic bone disease

2000 ◽  
Vol 36 (5) ◽  
pp. 953-961 ◽  
Author(s):  
M.Carmen Sánchez ◽  
M. Auxiliadora Bajo ◽  
Rafael Selgas ◽  
Alberto Mate ◽  
Isabel Millán ◽  
...  
Keyword(s):  
Peritoneal Dialysis ◽  
Bone Disease ◽  
Dialysis Patients ◽  
Adynamic Bone Disease ◽  
Adynamic Bone ◽  
Parathormone Secretion

Treatment experience and long-term follow-up data in two severe neonatal hyperparathyroidism cases

2016 ◽  
Vol 29 (9) ◽  
Author(s):  
Senay Savas-Erdeve ◽  
Elif Sagsak ◽  
Meliksah Keskin ◽  
Corinne Magdelaine ◽  
Anne Lienhardt-Roussie ◽  
...  
Keyword(s):  
Calcium Homeostasis ◽  
Parathyroid Glands ◽  
Calcium Sensing Receptor ◽  
Calcium Sensing ◽  
Long Term Follow Up ◽  
Calcium Reabsorption ◽  
Parathormone Secretion ◽  
Inactivating Mutations

AbstractThe calcium sensing receptor (CASR) is expressed most abundantly in the parathyroid glands and the kidney. CASR regulates calcium homeostasis through its ability to modulate parathormone secretion and renal calcium reabsorption. Inactivating mutations in the

Sign in / Sign up

Export Citation Format

Share Document