scholarly journals Coexistence of gastrointestinal Behçet’s disease, myelodysplastic syndrome and trisomy 8: A case report

2021 ◽  
Vol 13 (3) ◽  
pp. 134-136
Author(s):  
Erdal Bodakçi ◽  
Nazife Şule Yaşar Bilge ◽  
Neslihan Andıç ◽  
Timuçin Kaşifoğlu
Keyword(s):  
Case Report ◽  
Myelodysplastic Syndrome ◽  
Behçet’S Disease ◽  
Behcet’S Disease ◽  
Behçet's Disease ◽  
Trisomy 8 ◽  
Behcet's Disease

scholarly journals A case of Behcet's disease associated with myelodysplastic syndrome involving trisomy 8 and a gain-of-function mutation in SHP-2

Rheumatology ◽  
2011 ◽  
Vol 50 (7) ◽  
pp. 1342-1344 ◽  
Author(s):  
T. Shigemura ◽  
K. Agematsu ◽  
T. Yamazaki ◽  
K. Sakashita ◽  
Y. Nakayama ◽  
...  
Keyword(s):  
Myelodysplastic Syndrome ◽  
Behçet’S Disease ◽  
Behcet’S Disease ◽  
Behçet's Disease ◽  
Trisomy 8 ◽  
Gain Of Function ◽  
Behcet's Disease

scholarly journals Behcet's disease associated with myelodysplastic syndrome: a case report

1999 ◽  
Vol 14 (6) ◽  
pp. 685 ◽  
Author(s):  
Eun Jee Oh ◽  
Jeong Sook Yoon ◽  
Yeon Joon Park ◽  
Cheol Soo Cho ◽  
Byung Kee Kim
Keyword(s):  
Case Report ◽  
Myelodysplastic Syndrome ◽  
Behçet’S Disease ◽  
Behcet’S Disease ◽  
Behçet's Disease ◽  
Behcet's Disease

A Case of Behcet's Disease Associated with Schizophrenia and Myelodysplastic Syndrome with Trisomy 8 and 9

2013 ◽  
Vol 20 (6) ◽  
pp. 369
Author(s):  
Jung-Hoon Baek ◽  
Hyun-Jung Chun ◽  
Youn-Hee Park ◽  
Jeong-Hyeon Cho ◽  
Sang-Kyun Bae ◽  
...  
Keyword(s):  
Myelodysplastic Syndrome ◽  
Behçet’S Disease ◽  
Behcet’S Disease ◽  
Behçet's Disease ◽  
Trisomy 8 ◽  
Behcet's Disease

scholarly journals High Incidence of Gastrointestinal Ulceration and Cytogenetic Aberration of Trisomy 8 as Typical Features of Behçet’s Disease Associated with Myelodysplastic Syndrome: A Series of 16 Consecutive Chinese Patients from the Shanghai Behçet’s Disease Database and Comparison with the Literature

2018 ◽  
Vol 2018 ◽  
pp. 1-8 ◽  
Author(s):  
Yan Shen ◽  
Hai-Fen Ma ◽  
Dan Luo ◽  
Jian-Fei Cai ◽  
Jun Zou ◽  
...  
Keyword(s):  
Myelodysplastic Syndrome ◽  
Behçet’S Disease ◽  
Behcet’S Disease ◽  
Behçet's Disease ◽  
Chinese Patients ◽  
Trisomy 8 ◽  
Ileocecal Region ◽  
Behcet's Disease ◽  
Cytogenetic Aberration ◽  
Cytogenetic Aberrations

This study aimed to investigate the characteristics of Chinese patients with Behçet disease (BD) and myelodysplastic syndrome (MDS) and explore the role played by trisomy 8. This was a retrospective study of patients with BD and MDS from the Shanghai Behçet’s disease database who were diagnosed between October 2012 and July 2017. There were 805 patients with BD and 16 also had MDS. Trisomy 8 was examined in patients with BD-MDS and some patients with gastrointestinal (GI) BD. Patients with BD and MDS (16/805; 2%) were more likely to be female and older; display fever and intestinal lesions; have lower leukocyte count, hemoglobin, platelet count; and show higher C-reactive protein and erythrocyte sedimentation rate (ESR) than patients with BD without MDS (all P<0.05). Trisomy 8 was common (81.3%) in patients with BD-MDS. Ulcers in the ileocecal region were more frequently seen in intestinal patients with BD-MDS than in BD without MDS (90.0% versus 48.9%; P=0.032). GI ulceration is common in patients with BD-MDS. Cytogenetic aberrations, especially trisomy 8, may play a role in the pathogenesis of intestinal involvement in patients with BD-MDS.

scholarly journals Intestinal Behçet’s disease complicated by myelodysplastic syndrome and secondary pulmonary alveolar proteinosis: a case report

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Hiroshi Shimizu ◽  
Shuzo Sato ◽  
Tomohiro Suzuki ◽  
Tomomi Sasajima ◽  
Yosuke Takahata ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Myelodysplastic Syndrome ◽  
Behçet’S Disease ◽  
Behcet’S Disease ◽  
Chromosomal Abnormalities ◽  
Pulmonary Alveolar Proteinosis ◽  
Behçet's Disease ◽  
Trisomy 8 ◽  
Behcet's Disease ◽  
Alveolar Proteinosis

Abstract Background Gastrointestinal lesions, which sometimes develop in Behçet’s disease (BD), are referred to as intestinal BD. Although rare, intestinal BD can be accompanied by myelodysplastic syndrome (MDS) with abnormal karyotype trisomy 8, which is refractory to immunosuppressive therapy. Pulmonary alveolar proteinosis is a rare lung complication of BD and MDS. Herein, we present an extremely rare case of intestinal BD presenting with MDS and several chromosomal abnormalities, followed by secondary pulmonary proteinosis. Case presentation A 58-year-old Japanese woman with a 3-year history of genital ulcers and oral aphthae was admitted to our hospital. The patient developed abdominal pain and persistent diarrhea. Colonoscopy revealed multiple, round, punched-out ulcers from the terminal ileum to the descending colon. Intestinal BD was diagnosed and the patient was treated with colchicine, prednisolone, and adalimumab. However, her symptoms were unstable. Bone marrow examination to investigate the persistent macrocytic anemia revealed the presence of trisomy 8, trisomy 9, and X chromosome abnormalities (48, + 8, + 9, X, i(X) (q10) in 12 out of the examined 20 cells). Based on her hypoplastic bone marrow, the patient was diagnosed with low-risk MDS (refractory anemia). At the age of 61, the patient developed pneumonia with fever and diffuse ground-glass opacities on the lung computed tomography (CT). Chest high-resolution CT and histopathology via transbronchial lung biopsy revealed the presence of pulmonary alveolar proteinosis (PAP). These findings combined with the underlying disease led to the diagnosis of secondary PAP. Conclusions Secondary pulmonary proteinosis may accompany intestinal BD with MDS and several chromosomal abnormalities. Physicians should pay attention to lung complications, such as PAP, in patients with intestinal BD complicated by MDS. Genetic abnormalities may be associated with the development of such diseases.

Sign in / Sign up

Export Citation Format

Share Document