An important disease in the differential diagnosis of breast cancer: Idiopathic granulomatous mastitis

Background and Aim: Studies on hematological parameters in the differential diagnosis of idiopathic granulomatous mastitis (IGM) and breast cancer (BC) are limited. This study investigated whether preoperative fibrinogen and hematological indexes can be used in the differential diagnosis of patients with IGM and early-onset BC. Methods: Fifty patients with BC, 55 patients with IGM, and 50 healthy volunteer women were included in the study. Results: There was a statistically significant difference between the IGM and the BC with respect to fibrinogen, fibrinogen/albumin (Fib/Alb) ratio, C-reactive protein (CRP), white blood cells (WBC), neutrophils, neutrophil–lymphocyte ratio (NLR), platelet–lymphocyte ratio (PLR), and monocyte values. When fibrinogen (p < 0.001), the Fib/Alb ratio (p < 0.001), CRP (p < 0.001), WBC (p < 0.001), neutrophil (p < 0.001), NLR (p < 0.001), monocyte (p = 0.008), and 2-hour sedimentation rate (p < 0.001) were compared between the groups, the highest levels were found in the IGM group. There was a negative relationship between CRP and albumin, and a positive relationship was observed between CRP and WBC, NLR, PLR, and 2-h sedimentation rate. CRP had the highest sensitivity (95%), whereas the Fib/Alb ratio (86%) had the highest specificity. Patients with recurrent IGM had increased fibrinogen, Fib/Alb, CRP, neutrophils, NLR, and 2-h erythrocyte sedimentation rate (ESR) and decreased lymphocyte levels compared to non-recurrent patients. Conclusions: Preoperative CRP, albumin, fibrinogen, Fib/Alb, WBC, neutrophil, NLR, monocyte, and 2-h ESR have considerable potential to be early and sensitive biomarkers of IGM caused by inflammation compared to BC. These parameters also have a significant effect on the recurrence of the disease, suggesting their potential as a practical guide for the differential diagnosis of BC from IGM.

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Preoperative Fibrinogen and Hematological Indexes in the Differential Diagnosis of Idiopathic Granulomatous Mastitis and Breast Cancer

10.21203/rs.3.rs-460509/v1 ◽

2021 ◽

Author(s):

Mehmet Velidedeoglu ◽

Berrin Papila Kundaktepe ◽

Hulya Aksan ◽

Hafize Uzun

Keyword(s):

Breast Cancer ◽

Differential Diagnosis ◽

Sedimentation Rate ◽

White Blood Cells ◽

Negative Relationship ◽

Granulomatous Mastitis ◽

Idiopathic Granulomatous Mastitis ◽

Neutrophil Lymphocyte Ratio ◽

Lymphocyte Ratio ◽

Significant Difference

Abstract Background and Aim: Studies on hematological parameters in the differential diagnosis of idiopathic granulomatous mastitis (IGM) and breast cancer (BC) are limited. This study investigated whether preoperative fibrinogen and hematological indexes can be used in the differential diagnosis of patients with IGM and early-onset BC. Methods: Fifty patients with BC, 55 patients with IGM, and 50 healthy volunteer women were included in the study. Results: There was a statistically significant difference between the IGM and the BC with respect to fibrinogen, fibrinogen/albumin (Fib/Alb) ratio, C - reactive protein (CRP), white blood cells (WBC), neutrophils, neutrophil lymphocyte ratio (NLR), platelet lymphocyte ratio (PLR), and monocyte values. When fibrinogen (p <0.001), Fib/Alb ratio (p <0.001), CRP (p <0.001), WBC (p <0.001), neutrophil (p <0.001), NLR (p <0.001), monocyte (p = 0.008), and 2-hour sedimentation rate (p <0.001) were compared between the groups, the highest levels were found in the IGM group. There was a negative relationship between CRP and albumin, and a positive relationship was observed between CRP and WBC, NLR, PLR, and 2-h sedimentation rate. CRP had the highest sensitivity (95%), whereas the Fib/Alb ratio (86%) had the highest specificity. Patients with recurrent IGM had increased fibrinogen, FIB/ALB, CRP, neutrophils, NLR, and 2-h erythrocyte sedimentation rate (ESR) and decreased lymphocyte levels compared to non-recurrent patients. Conclusions: Preoperative CRP, albumin, fibrinogen, Fib/Alb, WBC, neutrophil, NLR, monocyte, and 2-h ESR have considerable potential to be early and sensitive biomarkers of IGM caused by inflammation compared to BC. These parameters also have a significant effect on the recurrence of the disease, suggesting a practical guide for the differential diagnosis of BC from IGM.

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Differential diagnosis of idiopathic granulomatous mastitis and breast cancer using acoustic radiation force impulse imaging

Journal of Medical Ultrasonics ◽

10.1007/s10396-016-0749-2 ◽

2016 ◽

Vol 44 (1) ◽

pp. 109-115 ◽

Cited By ~ 5

Author(s):

Memik Teke ◽

Fatma Teke ◽

Bircan Alan ◽

Ahmet Türkoğlu ◽

Cihad Hamidi ◽

...

Keyword(s):

Breast Cancer ◽

Differential Diagnosis ◽

Acoustic Radiation ◽

Radiation Force ◽

Acoustic Radiation Force ◽

Acoustic Radiation Force Impulse ◽

Granulomatous Mastitis ◽

Idiopathic Granulomatous Mastitis

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The Role of Interleukin-33 as an Inflammatory Marker in Differential Diagnosis of Idiopathic Granulomatous Mastitis and Breast Cancer

Journal of Investigative Surgery ◽

10.1080/08941939.2016.1240270 ◽

2016 ◽

Vol 30 (4) ◽

pp. 272-276 ◽

Cited By ~ 8

Author(s):

Mehmet Rafet Yigitbasi ◽

Gulcan Guntas ◽

Tuba Atak ◽

Cigdem Sonmez ◽

Haydar Yalman ◽

...

Keyword(s):

Breast Cancer ◽

Differential Diagnosis ◽

Inflammatory Marker ◽

Granulomatous Mastitis ◽

Idiopathic Granulomatous Mastitis ◽

Interleukin 33

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Breast Mass with Bloody Discharge: A Case of Idiopathic Granulomatous Mastitis

International Journal of Innovative Research in Medical Science ◽

10.23958/ijirms/vol07-i01/1338 ◽

2022 ◽

Vol 7 (01) ◽

pp. 58-61

Author(s):

Lamees AlSulaim

Keyword(s):

Breast Cancer ◽

Advanced Breast Cancer ◽

Nipple Discharge ◽

Advanced Breast ◽

Breast Mass ◽

Breast Diseases ◽

Granulomatous Mastitis ◽

Idiopathic Granulomatous Mastitis ◽

Skin Changes ◽

Breast Condition

One of the rare identity of breast diseases is Idiopathic Granulomatous Mastitis (IGM), a chronic inflammatory breast condition that can mimic advanced breast cancer. The case came with nipple discharge and mass with skin changes, which was definitively diagnosed following core-cut biopsy of the mastitis group idiopathic granulomatous.

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Idiopathic granulomatous mastitis - new approach in operative treatment

Srpski arhiv za celokupno lekarstvo ◽

10.2298/sarh200914006r ◽

2022 ◽

pp. 6-6

Author(s):

Milan Ranisavljevic ◽

Nenad Solajic ◽

Ferenc Vicko

Keyword(s):

Breast Cancer ◽

Surgical Treatment ◽

Breast Reconstruction ◽

Needle Biopsy ◽

Locally Advanced ◽

Clinical Problem ◽

Granulomatous Mastitis ◽

Childbearing Age ◽

Idiopathic Granulomatous Mastitis ◽

Operative Specimen

Introduction. Idiopathic granulomatous mastitis (GM) is described as a very rare, non-lactating, chronic mastitis that occurs primarily in women of childbearing age. Significant clinical problem related to GM is the diagnostic differentiation from breast cancer. Less advanced forms of GM can be successfully treated with limited surgical excisions and radical treatment is recommended only for the most extensive forms. Case report. First examination of the patient, by the surgeon at Oncology Institute of Vojvodina was in December 2018., when initial suspicion of breast cancer was set up. Core needle biopsy was performed and after histopathological (HP) analysis, confirmation of GM was obtained. The patient was initially offered Prednisone and Methotrexate therapy, which she refused and accepted only surgical treatment. Surgical treatment was performed few weeks after needle biopsy and consisted of performing a nipple spearing mastectomy with excision of the orifices of all fistulous ducts and their primary sutures. The HP findings of the operative specimen confirmed the diagnosis of GM. While there were no signs of dieses relapse, patient was suggested secondary reconstruction of the left breast. Twelve months after the primary operation, secondary breast reconstruction was performed with the interposition of a contoured silicone implant into a muscle pocket in a standard manner. Conclusion. Nipple spearing mastectomy with secondary breast reconstruction is aesthetically satisfactory treatment for patients with locally advanced GM.

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