Differential Expression of mRNAs Coding for Histone Deacetylases (HDACs) in the Nucleus Accumbens of Compulsive Methamphetamine Takers and Abstinent Rats

2016 ◽  
Vol 5 ◽  
pp. 1-9 ◽  
Author(s):  
Jean Lud Cadet ◽  
Bruce Ladenheim ◽  
Irina N. Krasnova ◽  
Subramaniam Jayanthi
Keyword(s):  
Nucleus Accumbens ◽  
Differential Expression ◽  
Histone Deacetylases

Differential expression of histone deacetylases during banana ripening and identification of MaHDA6 in regulating ripening-associated genes

2018 ◽  
Vol 141 ◽  
pp. 24-32 ◽  
Author(s):  
Chang-Chun Fu ◽  
Yan-Chao Han ◽  
Yu-Fan Guo ◽  
Jian-Fei Kuang ◽  
Jian-Ye Chen ◽  
...  
Keyword(s):  
Differential Expression ◽  
Histone Deacetylases

scholarly journals Repression by Homeoprotein Pitx1 of Virus-Induced Interferon A Promoters Is Mediated by Physical Interaction and trans Repression of IRF3 and IRF7

2002 ◽  
Vol 22 (20) ◽  
pp. 7120-7133 ◽  
Author(s):  
Marie-Laure Island ◽  
Thibault Mesplede ◽  
Nicole Darracq ◽  
Marie-Thérèse Bandu ◽  
Nicolas Christeff ◽  
...  
Keyword(s):  
Differential Expression ◽  
Transcriptional Activation ◽  
Histone Deacetylases ◽  
Transcriptional Activity ◽  
The Other ◽  
Differentially Expressed ◽  
Physical Interaction ◽  
Regulatory Factor ◽  
Other Hand ◽  
Transcription Activators

ABSTRACT Interferon A (IFN-A) genes are differentially expressed after virus induction. The differential expression of individual IFN-A genes is modulated by the specific transcription activators IFN regulatory factor 3 (IRF3) and IRF-7 and the homeoprotein transcription repressor Pitx1. We now show that repression by Pitx1 does not appear to be due to the recruitment of histone deacetylases. On the other hand, Pitx1 inhibits the IRF3 and IRF7 transcriptional activity of the IFN-A11 and IFN-A5 promoters and interacts physically with IRF3 and IRF7. Pitx1 trans-repression activity maps to specific C-terminal domains, and the Pitx1 homeodomain is involved in physical interaction with IRF3 or IRF7. IRF3 is able to bind to the antisilencer region of the IFN-A4 promoter, which overrides the repressive activity of Pitx1. These results indicate that interaction between the Pitx1 homeodomain and IRF3 or IRF7 and the ability of the Pitx1 C-terminal repressor domains to block IFN-A11 and IFN-A5 but not IFN-A4 promoter activities may contribute to our understanding of the complex differential transcriptional activation, repression, and antirepression of the IFN-A genes.

scholarly journals An Acute Methamphetamine Injection Downregulates the Expression of Several Histone Deacetylases (HDACs) in the Mouse Nucleus Accumbens: Potential Regulatory Role of HDAC2 Expression

2015 ◽  
Vol 30 (1) ◽  
pp. 32-40 ◽  
Author(s):  
Oscar V. Torres ◽  
Bruce Ladenheim ◽  
Subramaniam Jayanthi ◽  
Michael T. McCoy ◽  
Irina N. Krasnova ◽  
...  
Keyword(s):  
Nucleus Accumbens ◽  
Histone Deacetylases ◽  
Regulatory Role ◽  
Potential Regulatory Role

Chronic Methamphetamine Causes Differential Expression of Immediate Early Genes in the Nucleus Accumbens and Midbrain of Rats

2012 ◽  
Vol 1 ◽  
pp. 1-7
Author(s):  
Tiffany Garrett ◽  
Ingrid Tulloch ◽  
Michael T. McCoy ◽  
Bruce Ladenheim ◽  
Subramaniam Jayanthi ◽  
...  
Keyword(s):  
Nucleus Accumbens ◽  
Differential Expression ◽  
Immediate Early Genes ◽  
Immediate Early ◽  
Early Genes

scholarly journals Depressive-Like Behaviors Induced by Chronic Social Defeat Stress Are Associated With HDAC7 Reduction in the Nucleus Accumbens

2021 ◽  
Vol 11 ◽  
Author(s):  
Weijun Qian ◽  
Chao Yu ◽  
Shuai Wang ◽  
Aijun Niu ◽  
Guangyan Shi ◽  
...  
Keyword(s):  
Nucleus Accumbens ◽  
Histone Acetylation ◽  
Histone Deacetylase ◽  
Histone Deacetylases ◽  
Social Defeat ◽  
Social Avoidance ◽  
Social Defeat Stress ◽  
Persistent Symptoms ◽  
Promising Therapeutic Target ◽  
Chronic Social Defeat Stress

Persistent symptoms of depression indicate the adaptive involvement of stable molecules in the brain that may be manifested at the level of chromatin remodeling, such as histone acetylation. Former studies have identified alterations in histone acetylation and deacetylation in several animal models about depression. However, the specific histone deacetylases related with depression are needed to be explored. Here, social avoidance behaviors, anxiety-, and depression-like behaviors were all found in mice suffered from chronic social defeat stress. Moreover, we also discovered that the amount of the class II histone deacetylase, HDAC7 rather than HDAC2, was significantly decreased in the nucleus accumbens of defeated mice, which suggested that HDAC7 might be a crucial histone deacetylase in a chronic social defeat stress model. Our data showed that the depressive-like behaviors induced by chronic social defeat stress were associated with HDAC7 reduction in nucleus accumbens. HDAC7 might be a promising therapeutic target for depression.

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