Effects of global atrophy, white matter lesions, and cerebral blood flow on age-related changes in speed, memory, intelligence, vocabulary, and frontal function

2019 ◽  
pp. 337-366
Author(s):  
P.M.A. Rabbitt ◽  
O. Mogapi ◽  
M. Scott ◽  
M. Thacker ◽  
C. Lowe ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
White Matter ◽  
White Matter Lesions ◽  
Age Related ◽  
Age Related Changes

Effects of global atrophy, white matter lesions, and cerebral blood flow on age-related changes in speed, memory, intelligence, vocabulary, and frontal function.

2007 ◽  
Vol 21 (6) ◽  
pp. 684-695 ◽  
Author(s):  
Patrick Rabbitt ◽  
Oemetse Mogapi ◽  
Marietta Scott ◽  
Neil Thacker ◽  
Christine Lowe ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
White Matter ◽  
White Matter Lesions ◽  
Age Related ◽  
Age Related Changes

scholarly journals Multiple Factors Involved in the Pathogenesis of White Matter Lesions

2017 ◽  
Vol 2017 ◽  
pp. 1-9 ◽  
Author(s):  
Jing Lin ◽  
Dilong Wang ◽  
Linfang Lan ◽  
Yuhua Fan
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
White Matter ◽  
Genetic Factors ◽  
Subsequent Development ◽  
White Matter Lesions ◽  
Blood Brain Barrier Disruption ◽  
Fluid Attenuated Inversion Recovery ◽  
Cerebral Blood Flow Autoregulation ◽  
Brain Barrier Disruption

White matter lesions (WMLs), also known as leukoaraiosis (LA) or white matter hyperintensities (WMHs), are characterized mainly by hyperintensities on T2-weighted or fluid-attenuated inversion recovery (FLAIR) images. With the aging of the population and the development of imaging technology, the morbidity and diagnostic rates of WMLs are increasing annually. WMLs are not a benign process. They clinically manifest as cognitive decline and the subsequent development of dementia. Although WMLs are important, their pathogenesis is still unclear. This review elaborates on the advances in the understanding of the pathogenesis of WMLs, focusing on anatomy, cerebral blood flow autoregulation, venous collagenosis, blood brain barrier disruption, and genetic factors. In particular, the attribution of WMLs to chronic ischemia secondary to venous collagenosis and cerebral blood flow autoregulation disruption seems reasonable. With the development of gene technology, the effect of genetic factors on the pathogenesis of WMLs is gaining gradual attention.

474 AGE-RELATED CHANGES IN CEREBRAL BLOOD FLOW MAY EXPLAIN WORSE OUTCOME IN FEMALE HEAD TRAUMA PATIENTS

2005 ◽  
Vol 53 (1) ◽  
pp. S161.3-S161
Author(s):  
D. M. Lee ◽  
T. C. Glenn ◽  
W. J. Boscardin ◽  
J. F. Soustiel ◽  
N. A. Martin
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Head Trauma ◽  
Trauma Patients ◽  
Female Head ◽  
Age Related ◽  
Age Related Changes

P4-023: Cerebral blood flow, white matter lesions and cognitive performance. The Somatotrophics, Memory and Aging Research Trial (SMART)-MR Study

2008 ◽  
Vol 4 ◽  
pp. T674-T674
Author(s):  
Mirjam I. Geerlings ◽  
Auke P.A. Appelman ◽  
Koen L. Vincken ◽  
Willem P. Th M. Mali ◽  
Yolanda van der Graaf
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
White Matter ◽  
Cognitive Performance ◽  
White Matter Lesions ◽  
Aging Research ◽  
Mr Study

High total cerebral blood flow is associated with a decrease of white matter lesions

2004 ◽  
Vol 251 (12) ◽  
pp. 1481-1485 ◽  
Author(s):  
R. H. C. Bisschops ◽  
Y. Graaf ◽  
W. P. Th. M. Mali ◽  
J. Grond
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
White Matter ◽  
White Matter Lesions

scholarly journals IC-P1-025: Cerebral blood flow, white matter lesions and cognitive performance: The SMART-MR study

2008 ◽  
Vol 4 ◽  
pp. T18-T19
Author(s):  
Mirjam I. Geerlings ◽  
Auke P.A. Appelman ◽  
Koen L. Vincken ◽  
Willem P. Th M. Mali ◽  
Yolanda van der Graaf
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
White Matter ◽  
Cognitive Performance ◽  
White Matter Lesions ◽  
Mr Study
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