Challenges for potency assay development for gene therapies and the matrix approach

2021 ◽  
Author(s):  
Christina Grigoriadou ◽  
Shihua Lin ◽  
Dominic Hildebrand ◽  
Win Den Cheung ◽  
Roland Pach ◽  
...  
Author(s):  
Nizar Tahri

In this paper, we propose a novel generalized S-matrix characterization approach. The goal is to keep track of all observed discontinuities as efficiently as possible. In terms of reflection value, the proposed control strategy is based on transmission coefficients and one-axis rectangular guides. We successfully manipulate metal rectangular waveguide filters with both geometrical and physical discontinuity. Lossless discontinuity is depicted as a periodic structure that contains Metamaterials. The modal development of transverse fields provides the basis for the generalized S-matrix approach. The approach works by breaking down electromagnetic fields for each of the guides that make up the discontinuity on an orthonormal basis. When the Galerkin method is used, the matrix of diffraction of the junction is obtained directly.


2020 ◽  
Vol 498 (3) ◽  
pp. 3368-3373
Author(s):  
E V Polyachenko ◽  
I G Shukhman

ABSTRACT Using the canonical Hamilton–Jacobi approach we study the Lynden-Bell concept of bar formation based on the idea of orbital trapping parallel to the long or short axes of the oval potential distortion. The concept considered a single parameter – a sign of the derivative of the precession rate over angular momentum, determining the orientation of the trapped orbits. We derived a perturbation Hamiltonian that includes two more parameters characterizing the background disc and the perturbation, which are just as important as the earlier known one. This allows us to link the concept with the matrix approach in linear perturbation theory, the theory of weak bars, and explain some features of the non-linear secular evolution observed in N-body simulations.


2014 ◽  
Vol 9 (4) ◽  
pp. 497-512 ◽  
Author(s):  
Joydeep Basu ◽  
John W Ludlow

1973 ◽  
Vol 95 (3) ◽  
pp. 744-750 ◽  
Author(s):  
S. Hamid ◽  
A. H. Soni

Using the matrix approach, synthesis equations are derived for eight types of synthesis problems for an eight-link mechanism having five links in each of its three loops. A numerical approach due to Marquardt is applied to illustrate the synthesis technique for the varieties of motion programs.


2006 ◽  
Vol 20 (5) ◽  
pp. 573-601 ◽  
Author(s):  
Karl Aiginger ◽  
Susanne Sieber

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