The Arabidopsis heterotrimeric G protein α subunit, GPA1, is involved in guard cell CO2 signaling and interacts with early ABA and CO2 signal transduction elements

2020 ◽  
Author(s):  
Palanivelu Sengottaiyan
Keyword(s):  
Signal Transduction ◽  
G Protein ◽  
Guard Cell ◽  
Heterotrimeric G Protein ◽  
Α Subunit ◽  
G Protein Α Subunit

scholarly journals Rational design of a heterotrimeric G protein α subunit with artificial inhibitor sensitivity

2019 ◽  
Vol 294 (15) ◽  
pp. 5747-5758 ◽  
Author(s):  
Davide Malfacini ◽  
Julian Patt ◽  
Suvi Annala ◽  
Kasper Harpsøe ◽  
Funda Eryilmaz ◽  
...  
Keyword(s):  
G Protein ◽  
Rational Design ◽  
Heterotrimeric G Protein ◽  
Α Subunit ◽  
G Protein Α Subunit

The Receptor-Bound “Empty Pocket” State of the Heterotrimeric G-Protein α-Subunit Is Conformationally Dynamic†

Biochemistry ◽  
2006 ◽  
Vol 45 (43) ◽  
pp. 12986-12997 ◽  
Author(s):  
Najmoutin G. Abdulaev ◽  
Tony Ngo ◽  
Eva Ramon ◽  
Danielle M. Brabazon ◽  
John P. Marino ◽  
...  
Keyword(s):  
G Protein ◽  
Heterotrimeric G Protein ◽  
Α Subunit ◽  
G Protein Α Subunit

scholarly journals Heterotrimeric G protein α subunit is involved in rice brassinosteroid response

Cell Research ◽  
2006 ◽  
Vol 16 (12) ◽  
pp. 916-922 ◽  
Author(s):  
Lei Wang ◽  
Yun-Yuan Xu ◽  
Qi-Bin Ma ◽  
Dan Li ◽  
Zhi-Hong Xu ◽  
...  
Keyword(s):  
G Protein ◽  
Heterotrimeric G Protein ◽  
Α Subunit ◽  
G Protein Α Subunit

scholarly journals The Nucleotide‐Dependent Interactome of Rice Heterotrimeric G‐Protein α ‐Subunit

PROTEOMICS ◽  
2019 ◽  
Vol 19 (9) ◽  
pp. 1800385
Author(s):  
Akshaya Kumar Biswal ◽  
Evan Wesley McConnell ◽  
Emily Grace Werth ◽  
Shuen‐Fang Lo ◽  
Su‐May Yu ◽  
...  
Keyword(s):  
G Protein ◽  
Heterotrimeric G Protein ◽  
Α Subunit ◽  
G Protein Α Subunit

scholarly journals Heterotrimeric G-protein α-Subunit Adopts a “Preactivated” Conformation When Associated with βγ-Subunits

2005 ◽  
Vol 280 (45) ◽  
pp. 38071-38080 ◽  
Author(s):  
Najmoutin G. Abdulaev ◽  
Tony Ngo ◽  
Cheng Zhang ◽  
Andy Dinh ◽  
Danielle M. Brabazon ◽  
...  
Keyword(s):  
G Protein ◽  
Heterotrimeric G Protein ◽  
Α Subunit ◽  
G Protein Α Subunit

scholarly journals Identification of G Protein α Subunit-Palmitoylating Enzyme

2008 ◽  
Vol 29 (2) ◽  
pp. 435-447 ◽  
Author(s):  
Ryouhei Tsutsumi ◽  
Yuko Fukata ◽  
Jun Noritake ◽  
Tsuyoshi Iwanaga ◽  
Franck Perez ◽  
...  
Keyword(s):  
Signal Transduction ◽  
Plasma Membrane ◽  
G Protein ◽  
Adrenergic Receptor ◽  
Fluorescence Recovery After Photobleaching ◽  
G Protein Coupled Receptors ◽  
Α Subunit ◽  
Cytoplasmic Face ◽  
G Protein Α Subunit ◽  
G Protein Coupled

ABSTRACT The heterotrimeric G protein α subunit (Gα) is targeted to the cytoplasmic face of the plasma membrane through reversible lipid palmitoylation and relays signals from G-protein-coupled receptors (GPCRs) to its effectors. By screening 23 DHHC motif (Asp-His-His-Cys) palmitoyl acyl-transferases, we identified DHHC3 and DHHC7 as Gα palmitoylating enzymes. DHHC3 and DHHC7 robustly palmitoylated Gαq, Gαs, and Gαi2 in HEK293T cells. Knockdown of DHHC3 and DHHC7 decreased Gαq/11 palmitoylation and relocalized it from the plasma membrane into the cytoplasm. Photoconversion analysis revealed that Gαq rapidly shuttles between the plasma membrane and the Golgi apparatus, where DHHC3 specifically localizes. Fluorescence recovery after photobleaching studies showed that DHHC3 and DHHC7 are necessary for this continuous Gαq shuttling. Furthermore, DHHC3 and DHHC7 knockdown blocked the α1A-adrenergic receptor/Gαq/11-mediated signaling pathway. Together, our findings revealed that DHHC3 and DHHC7 regulate GPCR-mediated signal transduction by controlling Gα localization to the plasma membrane.

The Molecular Phylogeny of a Nematode-Specific Clade of Heterotrimeric G-Protein α-Subunit Genes

2006 ◽  
Vol 63 (1) ◽  
pp. 87-94 ◽  
Author(s):  
Damien M. O’Halloran ◽  
David A. Fitzpatrick ◽  
Grace P. McCormack ◽  
James O. McInerney ◽  
Ann M. Burnell
Keyword(s):  
Molecular Phylogeny ◽  
G Protein ◽  
Heterotrimeric G Protein ◽  
Α Subunit ◽  
G Protein Α Subunit
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