Prefrontal Symptomatology in People with Amyotrophic Lateral Sclerosis: Clinical Utility and Psychometric Properties of Prefrontal Symptoms Inventory (PSI)

2019 ◽  
Vol 105 (3) ◽  
Author(s):  
Ruiz-Sánchez De León JM ◽  
Motos-Muñoz M ◽  
De La Rubia Ortí JE
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Psychometric Properties ◽  
Clinical Utility ◽  
Lateral Sclerosis

Vestibular evoked myogenic potentials and their clinical utility in patients with amyotrophic lateral sclerosis

2019 ◽  
Vol 130 (5) ◽  
pp. 647-654 ◽  
Author(s):  
Xiaoxuan Liu ◽  
Shuo Zhang ◽  
Xiao Huang ◽  
Yingshuang Zhang ◽  
Dongsheng Fan
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Clinical Utility ◽  
Vestibular Evoked Myogenic Potentials ◽  
Lateral Sclerosis

scholarly journals Psychometric Properties of Preference-Based Measures for Economic Evaluation in Amyotrophic Lateral Sclerosis: A Systematic Review

2021 ◽  
Vol 2021 ◽  
pp. 1-13
Author(s):  
Nicole Peters ◽  
Vanina Dal Bello-Haas ◽  
Tara Packham ◽  
Ava Mehdipour ◽  
Ayse Kuspinar
Keyword(s):  
Systematic Review ◽  
Amyotrophic Lateral Sclerosis ◽  
Psychometric Properties ◽  
Full Text ◽  
Convergent Validity ◽  
Well Being ◽  
Global Scale ◽  
Meta Analyses ◽  
Lateral Sclerosis

Objective. The aim of this review was to synthesize the psychometric properties of generic preference-based measures (PBMs) of health-related quality of life (HRQL) in Amyotrophic Lateral Sclerosis (ALS). Methods. A systematic review was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Four databases were searched from inception to April 2019: OVID Medline, Embase, PsycINFO, and CINAHL. Studies were included if (1) the sample represented individuals with ALS, (2) a generic PBM was utilized and reported on, and (3) information on the psychometric property of a generic PBM was provided. Results. Ninety-one articles were screened, and 39 full-text articles were reviewed. Seven full-text articles were included in this review. The mean age of participants ranged from 58.1 to 63.8 years, and mean time since diagnosis ranged from 20.5 to 44.6 months. Two generic PBMs were found, the EQ-5D-3L (n = 6) and the Quality of Well-Being Self-Administered (QWB-SA) scale (n = 1). Convergent validity of the EQ-5D-3L was large against a global scale of self-perceived health (r = 0.60) and small to large against ALS specific HRQL measures (r = 0.19 to 0.75). For the QWB-SA scale, correlations were small against a generic measure (r = 0.21) and large against ALS specific measures (r = 0.55). The EQ-5D-3L discriminated across different disease severity; however, floor effects were reported. Conclusion. This review highlights the need for more rigorously designed studies to assess the psychometric properties of generic PBMs in ALS and the development of an ALS specific PBM that adequately reflects the health concerns of individuals with ALS.

scholarly journals Clinical utility of FDG-PET in amyotrophic lateral sclerosis and Huntington’s disease

2018 ◽  
Vol 45 (9) ◽  
pp. 1546-1556 ◽  
Author(s):  
Federica Agosta ◽  
◽  
Daniele Altomare ◽  
Cristina Festari ◽  
Stefania Orini ◽  
...  
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Huntington's Disease ◽  
Huntington’S Disease ◽  
Fdg Pet ◽  
Clinical Utility ◽  
Lateral Sclerosis

scholarly journals Psychometric Properties of Cognitive Assessment in Amyotrophic Lateral Sclerosis: A Systematic Review

2020 ◽  
Vol Volume 11 ◽  
pp. 181-194
Author(s):  
Tina Taule ◽  
Margaret Søvik ◽  
Regina Küfner Lein ◽  
Eike Wehling ◽  
Jörg Aßmus ◽  
...  
Keyword(s):  
Systematic Review ◽  
Amyotrophic Lateral Sclerosis ◽  
Psychometric Properties ◽  
Cognitive Assessment ◽  
Lateral Sclerosis

Psychometric Properties of Rapid Word-Based Rate Measures in the Assessment of Bulbar Amyotrophic Lateral Sclerosis: Comparisons With Syllable-Based Rate Tasks

2021 ◽  
pp. 1-14
Author(s):  
Sanjana Shellikeri ◽  
Reeman Marzouqah ◽  
Benjamin Rix Brooks ◽  
Lorne Zinman ◽  
Jordan R. Green ◽  
...  
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Psychometric Properties ◽  
Speaking Rate ◽  
Real Word ◽  
Characteristic Analysis ◽  
Motor Speech ◽  
Discriminatory Ability ◽  
Discrimination Ability ◽  
Electromagnetic Articulography ◽  
Lateral Sclerosis

Purpose Rapid maximum performance repetition tasks have increasingly demonstrated their utility as clinimetric markers supporting diagnosis and monitoring of bulbar disease in amyotrophic lateral sclerosis (ALS). A recently developed protocol uses novel real-word repetitions instead of traditional nonword/syllable sequences in hopes of improving sensitivity to motor speech impairments by adding a phonological target constraint that would activate a greater expanse of the motor speech neuroanatomy. This study established the psychometric properties of this novel clinimetric protocol in its assessment of bulbar ALS and compared performance to traditional syllable sequence dysdiadochokinetic (DDK) tasks. Specific objectives were to (a) compare rates between controls and speakers with symptomatic versus presymptomatic bulbar disease, (b) characterize their discriminatory ability in detecting presymptomatic bulbar disease compared to healthy speech, (c) determine their articulatory movement underpinnings, and (d) establish within-individual longitudinal changes. Method DDK and novel tongue (“ticker”—TAR) and labial (“pepper”—LAR) articulatory rates were compared between n = 18 speakers with presymptomatic bulbar disease, n = 10 speakers with symptomatic bulbar disease, and n = 13 healthy controls. Bulbar disease groups were determined by a previously validated speaking rate cutoff. Discriminatory ability was determined using receiver operating characteristic analysis. Within-individual change over time was characterized in a subset of 16 participants with available longitudinal data using linear mixed-effects models. Real-time articulatory movements of the tongue front, tongue dorsum, jaw, and lips were captured using 3-D electromagnetic articulography; effects of movement displacement and speed on clinimetric rates were determined using stepwise linear regressions. Results All clinimetric rates (traditional DDK tasks and novel tasks) were reduced in speakers with symptomatic bulbar disease; only TAR was reduced in speakers with presymptomatic bulbar disease and was able to detect this group with an excellent discrimination ability (area under the curve = 0.83). Kinematic analyses revealed associations with expected articulators, greater motor complexity, and differential articulatory patterns for the novel real-word repetitions than their DDK counterparts. Only LAR significantly declined longitudinally over the disease course. Conclusion Novel real-word clinimetric rate tasks evaluating tongue and labial articulatory dysfunction are valid and effective markers for early detection and tracking of bulbar disease in ALS.

Clinical utility of trapezius muscle studies in the evaluation of amyotrophic lateral sclerosis

2006 ◽  
Vol 13 (9) ◽  
pp. 908-912 ◽  
Author(s):  
Joong-Yang Cho ◽  
Jung Joon Sung ◽  
Ju-Hong Min ◽  
Kwang-Woo Lee
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Clinical Utility ◽  
Trapezius Muscle ◽  
Lateral Sclerosis

Automated Acoustic Analysis of Oral Diadochokinesis to Assess Bulbar Motor Involvement in Amyotrophic Lateral Sclerosis

2020 ◽  
Vol 63 (1) ◽  
pp. 59-73 ◽  
Author(s):  
Panying Rong
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Acoustic Analysis ◽  
Speaking Rate ◽  
Disease Stage ◽  
Healthy Controls ◽  
Tongue Movement ◽  
Major Barrier ◽  
Syllable Repetition ◽  
Oral Diadochokinesis ◽  
Lateral Sclerosis

Purpose The purpose of this article was to validate a novel acoustic analysis of oral diadochokinesis (DDK) in assessing bulbar motor involvement in amyotrophic lateral sclerosis (ALS). Method An automated acoustic DDK analysis was developed, which filtered out the voice features and extracted the envelope of the acoustic waveform reflecting the temporal pattern of syllable repetitions during an oral DDK task (i.e., repetitions of /tɑ/ at the maximum rate on 1 breath). Cycle-to-cycle temporal variability (cTV) of envelope fluctuations and syllable repetition rate (sylRate) were derived from the envelope and validated against 2 kinematic measures, which are tongue movement jitter (movJitter) and alternating tongue movement rate (AMR) during the DDK task, in 16 individuals with bulbar ALS and 18 healthy controls. After the validation, cTV, sylRate, movJitter, and AMR, along with an established clinical speech measure, that is, speaking rate (SR), were compared in their ability to (a) differentiate individuals with ALS from healthy controls and (b) detect early-stage bulbar declines in ALS. Results cTV and sylRate were significantly correlated with movJitter and AMR, respectively, across individuals with ALS and healthy controls, confirming the validity of the acoustic DDK analysis in extracting the temporal DDK pattern. Among all the acoustic and kinematic DDK measures, cTV showed the highest diagnostic accuracy (i.e., 0.87) with 80% sensitivity and 94% specificity in differentiating individuals with ALS from healthy controls, which outperformed the SR measure. Moreover, cTV showed a large increase during the early disease stage, which preceded the decline of SR. Conclusions This study provided preliminary validation of a novel automated acoustic DDK analysis in extracting a useful measure, namely, cTV, for early detection of bulbar ALS. This analysis overcame a major barrier in the existing acoustic DDK analysis, which is continuous voicing between syllables that interferes with syllable structures. This approach has potential clinical applications as a novel bulbar assessment.

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