scholarly journals Construction of a recombinant vaccinia virus expressing Babesia gibsoni thrombospondin-related anonymous protein and evaluation of its immunogenicity in mice

2020 ◽  
Vol 37 (4) ◽  
pp. 1029-1037
Vaccine ◽  
2007 ◽  
Vol 25 (7) ◽  
pp. 1334-1341 ◽  
Author(s):  
Shinya Fukumoto ◽  
Yoh Tamaki ◽  
Masashi Okamura ◽  
Hiroshi Bannai ◽  
Natsuko Yokoyama ◽  
...  

2013 ◽  
Vol 58 (4) ◽  
Author(s):  
Shinuo Cao ◽  
Ahmed Mousa ◽  
Gabriel Aboge ◽  
Ketsarin Kamyingkird ◽  
Mo Zhou ◽  
...  

AbstractA heterologous prime-boost vaccination regime with DNA and recombinant vaccinia virus (rvv) vectors expressing relevant antigens has been shown to induce effective immune responses against several infectious pathogens. In this study, we describe the effectiveness of the prime-boost strategy by immunizing dogs with a recombinant plasmid followed by vaccinia virus, both of which expressed the glutamic acid-rich protein (BgGARP) of Babesia gibsoni. The dogs immunized with the prime-boost regime developed a significantly high level of specific antibodies against BgGARP when compared with the control groups. The antibody level was strongly increased after a booster immunization with a recombinant vaccinia virus. Two weeks after the booster immunization with a recombinant vaccinia virus expressing BgGARP, the dogs were challenged with B. gibsoni parasite. The dogs immunized with the prime-boost regime showed partial protection, manifested as a significantly low level of parasitemia. These results indicated that this type of DNA/rvv prime-boost immunization approach may have use against B. gibsoni infection in dogs.


2006 ◽  
Vol 54 (2) ◽  
pp. 103 ◽  
Author(s):  
Jong Young Oh ◽  
Byeong Ho Park ◽  
Myong Jin Kang ◽  
Jin Han Cho ◽  
Jong Cheol Choi ◽  
...  

1988 ◽  
Vol 62 (1) ◽  
pp. 176-180 ◽  
Author(s):  
S L Hu ◽  
G D Plowman ◽  
P Sridhar ◽  
U S Stevenson ◽  
J P Brown ◽  
...  

1994 ◽  
Vol 68 (12) ◽  
pp. 8423-8427 ◽  
Author(s):  
C Metzger ◽  
D Michel ◽  
K Schneider ◽  
A Lüske ◽  
H J Schlicht ◽  
...  

1993 ◽  
Vol 22 (2-3) ◽  
pp. 92-99
Author(s):  
Shiu‐Lok Hu ◽  
Virginia Stallard ◽  
Kraig Abrams ◽  
Glen N. Barber ◽  
LaRene Kuller ◽  
...  

Sign in / Sign up

Export Citation Format

Share Document