Immunogenicity and growth inhibitory efficacy of the prime–boost immunization regime with DNA followed by recombinant vaccinia virus carrying the P29 gene of Babesia gibsoni in dogs

2009 ◽  
Vol 123 (4) ◽  
pp. 296-301 ◽  
Author(s):  
Shinya Fukumoto ◽  
Yoh Tamaki ◽  
Ikuo Igarashi ◽  
Hiroshi Suzuki ◽  
Xuenan Xuan
Keyword(s):  
Vaccinia Virus ◽  
Recombinant Vaccinia Virus ◽  
Babesia Gibsoni ◽  
Recombinant Vaccinia ◽  
Growth Inhibitory ◽  
Boost Immunization

Prime-boost immunization with DNA followed by a recombinant vaccinia virus expressing P50 induced protective immunity against Babesia gibsoni infection in dogs

Vaccine ◽  
2007 ◽  
Vol 25 (7) ◽  
pp. 1334-1341 ◽  
Author(s):  
Shinya Fukumoto ◽  
Yoh Tamaki ◽  
Masashi Okamura ◽  
Hiroshi Bannai ◽  
Natsuko Yokoyama ◽  
...  
Keyword(s):  
Vaccinia Virus ◽  
Protective Immunity ◽  
Recombinant Vaccinia Virus ◽  
Babesia Gibsoni ◽  
Recombinant Vaccinia ◽  
Boost Immunization

scholarly journals Prime-boost vaccination with plasmid DNA followed by recombinant vaccinia virus expressing BgGARP induced a partial protective immunity to inhibit Babesia gibsoni proliferation in dogs

2013 ◽  
Vol 58 (4) ◽  
Author(s):  
Shinuo Cao ◽  
Ahmed Mousa ◽  
Gabriel Aboge ◽  
Ketsarin Kamyingkird ◽  
Mo Zhou ◽  
...  
Keyword(s):  
Vaccinia Virus ◽  
Protective Immunity ◽  
Recombinant Vaccinia Virus ◽  
Babesia Gibsoni ◽  
Partial Protection ◽  
Recombinant Vaccinia ◽  
Booster Immunization ◽  
Boost Vaccination ◽  
Boost Immunization ◽  
High Level

AbstractA heterologous prime-boost vaccination regime with DNA and recombinant vaccinia virus (rvv) vectors expressing relevant antigens has been shown to induce effective immune responses against several infectious pathogens. In this study, we describe the effectiveness of the prime-boost strategy by immunizing dogs with a recombinant plasmid followed by vaccinia virus, both of which expressed the glutamic acid-rich protein (BgGARP) of Babesia gibsoni. The dogs immunized with the prime-boost regime developed a significantly high level of specific antibodies against BgGARP when compared with the control groups. The antibody level was strongly increased after a booster immunization with a recombinant vaccinia virus. Two weeks after the booster immunization with a recombinant vaccinia virus expressing BgGARP, the dogs were challenged with B. gibsoni parasite. The dogs immunized with the prime-boost regime showed partial protection, manifested as a significantly low level of parasitemia. These results indicated that this type of DNA/rvv prime-boost immunization approach may have use against B. gibsoni infection in dogs.

Prime-Boost Immunization of Codon Optimized HIV-1 CRF01_AE Gag in BCG with Recombinant Vaccinia Virus Elicits MHC Class I and II Immune Responses in Mice

2009 ◽  
Vol 38 (8) ◽  
pp. 762-779 ◽  
Author(s):  
Duanthanorm Promkhatkaew ◽  
Nadthanan Pinyosukhee ◽  
Wilai Thongdeejaroen ◽  
Jantima Teeka ◽  
Preeda Wutthinantiwong ◽  
...  
Keyword(s):  
Immune Responses ◽  
Vaccinia Virus ◽  
Mhc Class I ◽  
Recombinant Vaccinia Virus ◽  
Class I ◽  
Recombinant Vaccinia ◽  
Boost Immunization ◽  
Hiv 1

Anti-tumoral Effect of Recombinant Vaccinia Virus through US Guided Injection in a Rabbit Model of Hepatic VX2 Carcinoma

2006 ◽  
Vol 54 (2) ◽  
pp. 103 ◽  
Author(s):  
Jong Young Oh ◽  
Byeong Ho Park ◽  
Myong Jin Kang ◽  
Jin Han Cho ◽  
Jong Cheol Choi ◽  
...  
Keyword(s):  
Vaccinia Virus ◽  
Rabbit Model ◽  
Recombinant Vaccinia Virus ◽  
Recombinant Vaccinia ◽  
Vx2 Carcinoma

Characterization of a recombinant vaccinia virus expressing human melanoma-associated antigen p97.

1988 ◽  
Vol 62 (1) ◽  
pp. 176-180 ◽  
Author(s):  
S L Hu ◽  
G D Plowman ◽  
P Sridhar ◽  
U S Stevenson ◽  
J P Brown ◽  
...  
Keyword(s):  
Vaccinia Virus ◽  
Recombinant Vaccinia Virus ◽  
Human Melanoma ◽  
Recombinant Vaccinia

Human cytomegalovirus UL97 kinase confers ganciclovir susceptibility to recombinant vaccinia virus.

1994 ◽  
Vol 68 (12) ◽  
pp. 8423-8427 ◽  
Author(s):  
C Metzger ◽  
D Michel ◽  
K Schneider ◽  
A Lüske ◽  
H J Schlicht ◽  
...  
Keyword(s):  
Vaccinia Virus ◽  
Human Cytomegalovirus ◽  
Recombinant Vaccinia Virus ◽  
Recombinant Vaccinia
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