Simulation training is an interactive type of educational activity realized through immersion in the environment, by recreating a real clinical situation. At the same time, it is not possible to observe the maximum immersion in reality when training on the circulation of narcotic drug and psychotropic substance due to strict control measures on the part of the supervisory authorities in terms of the circulation of narcotic drugs and psychotropic substances. The article discusses options for resolving the issue of organizing simulation training on the circulation of narcotic and psychotropic substances for nurses.