scholarly journals PHẢN ỨNG DA NẶNG DO THUỐC

2020 ◽  
Vol 4 (6) ◽  
Author(s):  
Nguyen Van Khiem ◽  
Le Thi Minh Huong
Keyword(s):  
Adverse Reaction ◽  
Drug Reaction ◽  
Toxic Epidermal Necrolysis ◽  
Drug Eruption ◽  
Fixed Drug Eruption ◽  
Acute Generalized Exanthematous Pustulosis ◽  
Cutaneous Adverse Reaction ◽  
Fixed Drug ◽  
Exanthematous Pustulosis

Phản ứng da nặng (Severe Cutaneous Adverse Reaction, SCAR) do thuốc là một nhóm các phản ứng dị ứng thuốc gây tổn thương nghiêm trọng đến da và niêm mạc, trong những trường hợp nặng có thể ảnh hưởng đến các cơ quan nội tạng, thậm chí gây tử vong. Ngoài thuốc, một số tác nhân nhiễm trùng như Mycoplasma pneumoniacũng có thể gây ra SCAR, đặc biệt ở trẻ em. Trong bài này, xin được tập trung vào SCAR do thuốc. SCAR bao gồm các hội chứng sau: Hội chứng Steven – Johnson (SJS) Hội chứng hoạt tử thượng bì nhiễm độc (Toxic Epidermal Necrolysis, TEN, trước đây còn được gọi là hội chứng Lyell) Hội chứng chuyển tiếp giữa SJS và TEN (SJS/TEN overlap) Hội chứng phản ứng với thuốc có triệu chứng toàn thân và tăng bạch cầu ái toan (Drug Reaction with Eosinophilia and Systemic Symtoms, DRESS). Ban mụn mủ toàn thân cấp tính (Acute Generalized Exanthematous Pustulosis, AGEP). Gần đây, phát ban cố định do thuốc thể bọng nước lan tỏa (Generalized Bullous Fixed Drug Eruption, GBFDE) cũng được một số bác sĩ xếp vào SCAR. Tuy nhiên GBFDE thường ít nguy hiểm hơn cũng như rất hiếm gặp ở trẻ em. Trong các hội chứng trên, SJS, TEN và hội chứng chuyển tiếp SJS/TEN được cho là cùng một bệnh với các mức độ nặng khác nhau. Trong bài này, chúng được kí hiệu chung là SJS-TEN

scholarly journals Doxycycline induced fixed drug eruption: a case report

2018 ◽  
Vol 7 (11) ◽  
pp. 2264
Author(s):  
Isswariya Anandan ◽  
Nitya Selvaraj ◽  
Suganya Ganesan ◽  
Meher Ali Rajamohammad ◽  
Nalinidevi Jayabalan
Keyword(s):  
Adverse Drug Reaction ◽  
Drug Reaction ◽  
Drug Eruption ◽  
Skin Lesions ◽  
Severity Assessment ◽  
Fixed Drug Eruption ◽  
Skin Reactions ◽  
Dermatological Examination ◽  
Causative Drug ◽  
Fixed Drug

Fixed drug eruption (FDE) is an adverse drug reaction seen with various groups of drugs are antibiotics such as trimethoprim -sulphamethoxazle, pencillin, tetracyclines, non steroidal anti- inflammatory drugs like ibuprofen, aspirin etc. Doxycycline belongs to tetracycline groups of antibiotics. We herein present the case of Doxycycline induced fixed drug eruption. A 35-year - old man presented to our hospital, with a 2-day history of itching and hyperpigmentation over the chest. Patient developed skin lesion 2 days after and he started taking Doxycycline 100 mg twice a day for skin infections. Dermatological examination revealed multiple well defined hyperpigmented patches seen over the anterior aspect of the chest. Doxycycline was discontinued immediately, and the skin lesions resolved spontaneously within 2 weeks. Causality assessment by using Naranjo adverse drug reaction probability scale and WHO Uppsala monitoring scale categorize the reaction as Doxycycline was the probable cause for the adverse drug reaction. Severity assessment by using modified Hartwig and Siegel ADR severity assessment scale labelled the reaction as mild-level 2. The causative drug or drugs and cross reactants should be avoided in future to prevent recurrence of similar skin reactions.

Generalized bullous fixed drug eruption mimicking toxic epidermal necrolysis caused by paracetamol

2018 ◽  
Vol 2 (1) ◽  
pp. 34
Author(s):  
BanavasiShanmukha Girisha ◽  
TonitaMariola Noronha ◽  
AkshataCharan Alva ◽  
Ashok Menon
Keyword(s):  
Toxic Epidermal Necrolysis ◽  
Drug Eruption ◽  
Fixed Drug Eruption ◽  
Fixed Drug

Prognosis of generalized bullous fixed drug eruption: comparison with Stevens-Johnson syndrome and toxic epidermal necrolysis

2013 ◽  
Vol 168 (4) ◽  
pp. 726-732 ◽  
Author(s):  
S. Lipowicz ◽  
P. Sekula ◽  
S. Ingen-Housz-Oro ◽  
Y. Liss ◽  
B. Sassolas ◽  
...  
Keyword(s):  
Toxic Epidermal Necrolysis ◽  
Drug Eruption ◽  
Stevens Johnson Syndrome ◽  
Fixed Drug Eruption ◽  
Johnson Syndrome ◽  
Fixed Drug

scholarly journals Pustular Psoriasis and Acute Generalized Exanthematous Pustulosis

Medicina ◽  
2021 ◽  
Vol 57 (10) ◽  
pp. 1004
Author(s):  
Morgan Sussman ◽  
Anthony Napodano ◽  
Simo Huang ◽  
Abhirup Are ◽  
Sylvia Hsu ◽  
...  
Keyword(s):  
Adverse Reaction ◽  
Clinical Course ◽  
Pustular Psoriasis ◽  
Topical Steroids ◽  
Inflammatory Disorder ◽  
Acute Generalized Exanthematous Pustulosis ◽  
Cutaneous Adverse Reaction ◽  
History Of ◽  
Exanthematous Pustulosis ◽  
Crucial Part

The similarity between pustular psoriasis (PP) and acute generalized exanthematous pustulosis (AGEP) poses problems in the diagnosis and treatment of these two conditions. Significant clinical and histopathologic overlap exists between PP and AGEP. PP is an inflammatory disorder that has numerous clinical subtypes, but all with sterile pustules composed of neutrophils. AGEP is a severe cutaneous adverse reaction that is also characterized by non-follicular sterile pustules. Clinical features that suggest a diagnosis of PP over AGEP include a history of psoriasis and the presence of scaling plaques. Histologically, eosinophilic spongiosis, vacuolar interface dermatitis, and dermal eosinophilia favor a diagnosis of AGEP over PP. Importantly, PP and AGEP vary in clinical course and treatment. PP treatment involves topical steroids, oral retinoids, and systemic immunosuppressants. Newer therapies targeting IL-36, IL-23, IL-1, and PDE-4 have been investigated. The removal of the offending agent is a crucial part of the treatment of AGEP.

scholarly journals A case of self-treatment induced oral mucosal fixed drug eruptions associated with use of tinidazole - a case report

2021 ◽  
Vol 9 (6) ◽  
pp. 1794
Author(s):  
Swathi C. Prabhu ◽  
Harshavardhan K. Shetty
Keyword(s):  
Adverse Reaction ◽  
Case Report ◽  
Oral Mucosa ◽  
Medical Practice ◽  
Drug Eruption ◽  
Case Reports ◽  
Common Site ◽  
Fixed Drug Eruption ◽  
Drug Eruptions ◽  
Fixed Drug

Fixed drug eruptions (FDE) is a type of adverse reaction to drugs encountered in medical practice. Skin, glans penis is most common site of involvement. We hereby report a case of fixed drug eruption on oral mucosa due to tinidazole, a nitroimidazole-derivative which the patient had taken as he was suffering from gastro-intestinal distress. Very limited case reports have been found in literature with respect to tinidazole causing FDE.

Acute Generalized Exanthematous Pustulosis Induced by Hydroxychloroquine: First Case Report in Canada and Review of the Literature

2013 ◽  
Vol 17 (6) ◽  
pp. 414-418 ◽  
Author(s):  
Kristy Bailey ◽  
Daniel Mckee ◽  
Judy Wismer ◽  
Neil Shear
Keyword(s):  
Adverse Reaction ◽  
Case Report ◽  
Drug Eruption ◽  
Spontaneous Resolution ◽  
Review Of The Literature ◽  
Acute Generalized Exanthematous Pustulosis ◽  
First Case ◽  
Pathologic Findings ◽  
Complicated Course ◽  
Exanthematous Pustulosis

Background: Acute generalized exanthematous pustulosis (AGEP) is a rare drug eruption presenting with an acute, extensive formation of nonfollicular sterile pustules on an erythematous and edematous base. Typically, the rash is accompanied by fever and leukocytosis, with spontaneous resolution in < 15 days. The incidence of AGEP is estimated at one to five cases per million people per year. Only 18% of these are from nonantibiotics. Hydroxychloroquine (HCQ) is an antimalarial agent that is also used to treat various dermatologic and rheumatologic conditions. Objective: We report the first observation in Canada of a patient with AGEP induced by HCQ. Methods and Results: AGEP was diagnosed in a 48-year-old female who had been taking HCQ for 2 weeks and then developed a diffuse erythematous and edematous pustular eruption. Clinical and pathologic findings were consistent with a diagnosis of AGEP. The patient was treated with steroids and supportive measures. The rash resolved after 18 days and a complicated course in hospital. Conclusion: AGEP is a rare drug eruption, usually to antibiotics. We report the first case in Canada of AGEP as an adverse reaction to HCQ. Clinicians should keep in mind the possibility of this severe skin eruption.

Relapsing generalized bullous fixed drug eruption: a severe and avoidable cutaneous drug reaction. Three case reports

Therapies ◽  
2021 ◽  
Author(s):  
Clément Braesch ◽  
Amandine Weill ◽  
Olivier Gaudin ◽  
Bénédicte Lebrun-Vignes ◽  
Charlotte Bernigaud ◽  
...  
Keyword(s):  
Drug Reaction ◽  
Drug Eruption ◽  
Case Reports ◽  
Fixed Drug Eruption ◽  
Fixed Drug ◽  
Cutaneous Drug Reaction
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