A Case of Herpes Zoster Ophthalmicus with Ocular Involvement in an Immunocompromised Patient

Author(s):  
Hannah Roomi
1970 ◽  
Vol 3 (2) ◽  
pp. 165-171 ◽  
Author(s):  
LR Puri ◽  
GB Shrestha ◽  
DN Shah ◽  
M Chaudhary ◽  
A Thakar

Background: Ocular complications of herpes zoster ophthalmicus (HZO) may lead to substantial visual disability, severe post-herpetic neuralgia and rarely fatal cerebral complications. Aim: To identify the pattern of ocular manifestation in herpes zoster ophthalmicus. Materials and methods: A cross-sectional descriptive study was under taken including the clinically diagnosed cases of HZO. All of them underwent a complete ophthalmological evaluation. Results: Sixty-eight cases of HZO were examined, of which 37 (54.4 %) were male and 31 (45.6%) female. The mean age was 48.7 ± 18.5 years. Most of the patients (64.7 %) were above the age of 40 years. 77.94 % of the patients had some form of ocular involvement. Pain (77.9 %) was the commonest ocular complaint. In young patients less than 35 years, HIV was the most common risk factor (19.3 %).Visual status was good in the majority (73.5 %) of patients at presentation. Lid and adnexal findings (45.8 %) were most common ocular involvement followed by conjunctivitis (41.1 %). Corneal complication was seen in 38.2 % of cases, uveitis in 19.1 % and post-herpetic neuralgia (PHN) and secondary glaucoma each in 5.8 %. Conclusion: Eyelid and ocular adnexal involvement is most commonly found in patients with herpes zoster ophthalmicus followed by corneal complication and uveitis. There needs to be awareness of ocular involvement, which can be sight threatening, among the HZO patients and other medical departments and an increased emphasis on regular ophthalmic examination. Key words: herpes virus, herpes zoster, conjunctivitis, keratitis DOI: http://dx.doi.org/10.3126/nepjoph.v3i2.5271 Nepal J Ophthalmol 2011; 3(2): 165-171


1970 ◽  
Vol 2 (1) ◽  
pp. 45-50 ◽  
Author(s):  
G Lamichhane ◽  
DN Shah ◽  
S Sharma ◽  
M Chaudhary

Background: A significant number of patients with HIV/AIDS can have ocular manifestations. Almost every structure in the eyes can be affected in this condition. Objective: To study various ocular manifestations in the cases known to be infected with HIV. Materials and methods: A cross-sectional descriptive study was carried out including 117 subjects positive for HIV using the purposive sampling method. Their demographic pattern and ocular findings were studied. Findings were recorded in the pro forma developed for the study. Statistics: SPSS ver 14.0 was used for data analysis. The p value of <0.05 was considered as significant. Results: A total of 117 HIV infected cases were included in this study. Among them, 76 (64.95 %) were male and 41 (35.05 %) female. The mean age of the subjects was 30.04 ± 11.32 years. The duration of HIV detection ranged from 1-5 years. Ocular complaints were present in 26.49 % of the subjects. Ocular manifestations were present in 56 % of the patients with complaints and in 27.3 % of asymptomatic patients. Ocular involvement was seen in 55 (47 %) patients. The common anterior segment findings were herpes zoster ophthalmicus (4.27 %), anterior uveitis (2.56 %), blepharitis (2.56 %) and conjunctivitis (1.7 %), whereas HIV retinopathy (19.6 %), CMV retinitis (5.1 %), ocular toxoplasmosis (2.5 %) and presumed ocular tuberculosis (0.85 %) were common posterior segment findings. Conclusion: Herpes zoster ophthalmicus, anterior uveitis, HIV retinopathy and CMV retinitis are common ocular manifestations associated with HIV infections. Keywords: HIV/AIDS; anterior and posterior segments; ocular involvement DOI: 10.3126/nepjoph.v2i1.3704 Nep J Oph 2010;2(1) 45-50


2016 ◽  
Vol 19 (3) ◽  
pp. A212
Author(s):  
H.F. Tseng ◽  
C. Zheng ◽  
Y. Luo ◽  
L.S. Sy ◽  
C. Mercado ◽  
...  

2017 ◽  
Vol 15 (5) ◽  
pp. 563-564
Author(s):  
Florian Butsch ◽  
Dania Greger ◽  
Christina Butsch ◽  
Esther von Stebut

2020 ◽  
Vol 68 (7) ◽  
pp. 1457
Author(s):  
Jagat Ram ◽  
Surbhi Khurana ◽  
ParulChawla Gupta ◽  
AshokKumar Singh

Author(s):  
Chengyi Zheng ◽  
Lina S Sy ◽  
Hilary Tanenbaum ◽  
Yun Tian ◽  
Yi Luo ◽  
...  

Abstract Background Diagnosis codes are inadequate for accurately identifying herpes zoster ophthalmicus. Manual review of medical records is expensive and time-consuming, resulting in a lack of population-based data on herpes zoster ophthalmicus. Methods We conducted a retrospective cohort study, including 87,673 patients aged ≥50 years who had a new HZ diagnosis and associated antiviral prescription between 2010-2018. We developed and validated an automated natural language processing (NLP) algorithm to identify herpes zoster ophthalmicus (HZO) with ocular involvement (ocular HZO). We compared the characteristics of NLP-identified ocular HZO, nonocular HZO, and non-HZO cases among HZ patients and identified the factors associated with ocular HZO among HZ patients. Results The NLP algorithm achieved 94.9% sensitivity and 94.2% specificity in identifying ocular HZO cases. Among 87,673 incident HZ cases, the proportion identified as ocular HZO was 9.0% (n=7,853) by NLP and 2.3% (n=1,988) by ICD codes. In adjusted analyses, older age and male sex were associated with an increased risk of ocular HZO; Hispanic and Black race/ethnicity each were associated with a lower risk of ocular HZO compared to non-Hispanic White. Conclusions The NLP algorithm achieved high accuracy and can be used in large population-based studies to identify ocular HZO, avoiding labor-intensive chart review. Age, sex, and race were strongly associated with ocular HZO among HZ patients. We should consider these risk factors when planning for zoster vaccination.


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