scholarly journals Synthesis n-oxides of pyridylacethylene amines based on 2-methyl-5-ethynylpyridine

2021 ◽  
pp. 48-53
Keyword(s):  
Reaction Time ◽  
Acetic Anhydride ◽  
Mannich Reaction ◽  
Aromatic Amines ◽  
Pmr Spectroscopy ◽  
The Mannich Reaction

The aim of this work is to study the reaction of 2-methyl-5-ethynylpyridine N-oxide with some aliphatic and aromatic amines to obtain N-oxides of pyridylacetylenic amines. 2-Methyl-5-ethylpyridine converted to 2-methyl-5-vinylpyridine by dehydrogenation, and 2-methyl-5-ethynylpyridine obtained by bromination and dehydrobromination. 2-methyl-5-ethynylpyridine N-oxide synthesized by oxidation of 2-methyl-5-ethynylpyridine with perhydrol in acetic anhydride. The synthesis of N-oxides of pyridylacetylenic amines by the Mannich reaction carried out. The effect of the solvents: methanol, ethanol and n-dioxane, the catalyst, and the reaction time on the yield of the final product studied. The structure and composition of the synthesized PAA N-oxides were established using IR and PMR spectroscopy.

The Mannich Reaction Between Aromatic Ketones, Aromatic Aldehydes and Aromatic Amines

Synthesis ◽  
1991 ◽  
Vol 1991 (09) ◽  
pp. 717-718 ◽  
Author(s):  
Yi Lin ◽  
Lei Huangshu ◽  
Zou Junhua ◽  
Xu Xiujuan
Keyword(s):  
Mannich Reaction ◽  
Aromatic Amines ◽  
Aromatic Aldehydes ◽  
Aromatic Ketones ◽  
The Mannich Reaction

Ultrasound-assisted rapid synthesis of β-aminoketones with direct-type catalytic Mannich reaction using bismuth(III) triflate in aqueous media at room temperature

2012 ◽  
Vol 66 (1) ◽  
Author(s):  
S. Ozturkcan ◽  
Kadir Turhan ◽  
Zuhal Turgut
Keyword(s):  
Reaction Time ◽  
Mannich Reaction ◽  
Aromatic Amines ◽  
Room Temperature ◽  
Aqueous Media ◽  
Aromatic Aldehydes ◽  
Rapid Synthesis ◽  
Low Toxicity ◽  
Ultrasound Assisted ◽  
Easy Operation

AbstractAn innovative, powerful, efficient and relatively rapid method was developed to synthesise various β-aminoketone derivatives from cyclohexanone, substituted aromatic amines and aromatic or hetero-aromatic aldehydes via ultrasound-assisted direct-type catalytic Mannich reaction using bismuth(III) triflate in water. Good yields of the desired β-aminoketones were obtained at room temperature by ultrasound-assisted reaction within 1–2 h. The major advantages of the proposed method are undemanding conditions, easy operation, low toxicity, shorter reaction time, anti selectivity and higher yields in comparison with conventional methods.

One-pot three-component Mannich reaction in water catalyzed by eco-friendly, hydrophobic and recyclable sulfonic acid based nanosilica (SBA-15-Ph-PrSO3H)

RSC Advances ◽  
2014 ◽  
Vol 4 (71) ◽  
pp. 37941-37946 ◽  
Author(s):  
Daryoush Zareyee ◽  
Hamidreza Alizadeh
Keyword(s):  
Mannich Reaction ◽  
Aromatic Amines ◽  
Sulfonic Acid ◽  
Room Temperature ◽  
Aromatic Aldehydes ◽  
Green Method ◽  
One Pot ◽  
The Mannich Reaction ◽  
Reaction In Water

A mild, effective and green method for the Mannich reaction of aromatic aldehydes, aromatic amines and ketones has been accomplished in good to excellent yields using hydrophobic SBA-15-Ph-PrSO3H in water at room temperature.

THE MANNICH REACTION OF CYCLIC KETONES, AROMATIC ALDEHYDES AND AROMATIC AMINES

1991 ◽  
Vol 23 (5) ◽  
pp. 673-676 ◽  
Author(s):  
Yi Lin ◽  
Zou Junhua ◽  
Lei Huangshu ◽  
Lin Xiaomei ◽  
Zhang Mingxiao
Keyword(s):  
Mannich Reaction ◽  
Aromatic Amines ◽  
Aromatic Aldehydes ◽  
Cyclic Ketones ◽  
The Mannich Reaction

A Convenient One-Pot Synthesis of Pyrazolo[3,4-d]pyrimidines and s-Triazolo[3,4-b][1,3,5]thiadiazines

1997 ◽  
Vol 52 (11) ◽  
pp. 1401-1412 ◽  
Author(s):  
Zeinab A. Hozien ◽  
Abd El-Wareth A. O. Sarhan ◽  
Hassan A. H. El-Sherief ◽  
Abdalla M. Mahmoud
Keyword(s):  
Mannich Reaction ◽  
Aromatic Amines ◽  
Good Yield ◽  
Room Temperature ◽  
Secondary Amines ◽  
One Pot ◽  
Aminomethyl Derivatives ◽  
Primary Aromatic Amines ◽  
The Mannich Reaction ◽  
Primary Aliphatic Amines

Abstract The reaction of 5-amino-3-aryl-1-phenylpyrazoles (1a-d) with formaldehyde and secondary amines in boiling ethanol gave the corresponding 4-alkylaminomethyl derivatives (2a-f) and bis-(4-pyrazolyl)methane (4a,b) as byproduct. Such reaction with primary aliphatic and aro­ matic amines at room temperature afforded 1,3,5-trisubstituted (5a-h) and 1,3.5,7-tetrasubstituted tetrahydropyrazolo[3,4-d]pyrimidines (8a-k) respectively in good yield. Similarily, the Mannich reaction of 5-mercapto-3-phenyl-1,2,4-triazole (9) with secondary amines, in boiling ethanol, and primary aromatic amines, at room temperature, gave 2 -substituted aminomethyl derivatives (10a-c) and (14a-g) respectively,while with primary aliphatic amines, p-toluidine and p-anisidine,at room temperature,and with other primary aromatic amines, in boiling ethanol, afforded the cyclized products 12,4-triazolo[3,4-b]thiadiazines (13a-e); (15f,g) and (15a-e), respectively.

The Mannich Reaction of Butanone, Aromatic Aldehydes and Aromatic Amines

1991 ◽  
Vol 21 (20) ◽  
pp. 2109-2117 ◽  
Author(s):  
Yi Lin ◽  
Zou Junhua ◽  
Lei Huangshu ◽  
He Qilin
Keyword(s):  
Mannich Reaction ◽  
Aromatic Amines ◽  
Aromatic Aldehydes ◽  
The Mannich Reaction
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