Role of bone marrow examination in the evaluation of infections: clinico-hematological analysis in a tertiary care centre

Objective: To determine the frequency of haematological disorders diagnosed by bone marrow examination at a tertiary care centre in Quetta, Balochistan. Study Design: Prospective observational study. Place and Duration of Study: Department of Pathology, Combined Military Hospital Quetta, from Jan 2018 to May 2019. Methodology: A total of 101 one patients, who underwent bone marrow examination, were included in the study. Brief history, clinical examination and indication of procedure were also endorsed in a questionnaire designed for the study. Results: Bone marrow of one hundred and one patients, included in the study, were evaluated. Mean age of the patients was 32.3 ± 18.4 years. There were 68 males (67%), while 33 were females (33%) with 2:1 male to female ratio. Pyrexia of unknown origin (PUO) was the most common indication for bone marrow examination with frequency of 20.7%. Nutritional anaemia was the most prevalent benign disorder (17%), whereas Acute Lymphoblastic leukaemia (ALL) accounted about 6.8% which is highest in malignant disorders. Conclusion: This study has concluded that bone marrow examination is a useful technique and findings of bone marrow can modify the treatment. Thus procedure has a great diagnostic value. Both bone marrow aspiration (BMA) and bone marrow biopsy (BMB) are the complimentary techniques and supremacy of one method on other depends on the disorder.

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Clinico-etiological profile of pancytopenia in paediatric patients with special reference to bone marrow examination: A tertiary care centre based study

International Journal of Clinical and Diagnostic Pathology ◽

10.33545/pathol.2020.v3.i3e.301 ◽

2020 ◽

Vol 3 (3) ◽

pp. 307-310

Author(s):

Bhati Sonal ◽

Parakh Priyanka ◽

Meena Seema

Keyword(s):

Bone Marrow ◽

Special Reference ◽

Tertiary Care ◽

Bone Marrow Examination ◽

Care Centre ◽

Tertiary Care Centre ◽

Paediatric Patients

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BONE MARROW EXAMINATION- A TWO-YEAR STUDY AT A TERTIARY CARE CENTRE

Journal of Evolution of Medical and Dental Sciences ◽

10.14260/jemds/2018/549 ◽

2018 ◽

Vol 7 (20) ◽

pp. 2442-2445

Author(s):

Zaheda Kauser ◽

Naga Kalyani Pathuri ◽

Anunayi Jeshtadi ◽

Ezhil Arasi Nagamuthu

Keyword(s):

Bone Marrow ◽

Tertiary Care ◽

Bone Marrow Examination ◽

Care Centre ◽

Tertiary Care Centre

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Bicytopenia/pancytopenia in children - clinico etiological profile and importance of bone marrow evaluation in a tertiary care centre

International Journal of Contemporary Pediatrics ◽

10.18203/2349-3291.ijcp20205514 ◽

2020 ◽

Vol 8 (1) ◽

pp. 102

Author(s):

Lalita Wadhwa ◽

Suman Chirla ◽

Maheshwari K. ◽

Puneet Wadhwa

Keyword(s):

Bone Marrow ◽

Tertiary Care ◽

Bone Marrow Examination ◽

Study Data ◽

Clinical Feature ◽

Tertiary Care Centre ◽

Peripheral Smear ◽

Bone Marrow Evaluation ◽

Hematological Analysis ◽

Common Etiology

Background: Peripheral cytopenia is a common hematological problem in our day-to-day clinical practice resulting from various diseases ranging from transient infection induced bone marrow suppression to life threatening hematological malignancies. The objective of this study was to know the clinicoetiological profile,hematological analysis and importance of bone marrow evaluation of bicytopenia/pancytopenia in children in a tertiary care teaching hospital.Methods: This was a retrospective, observational study, conducted in pediatric department, NRIIMS, Visakhapatnam, Andhra Pradesh from May 2019 to May 2020. All children in the age group of 1-18yrs of age admitted with new onset bicytopenia/pancytopenia who underwent hematological analysis and bone marrow examination in our hospital were included in this study. Children with bicytopenia/ pancytopenia evaluated outside/treated in other hospitals were excluded from our study. Data was obtained from bone marrow biopsy register from pathology department, admission register of pediatric ward and hospital medical records.Results: Out of the 31 children studied, males were (54.8%), females were (45.2%).11-18 years of age were (51.6%), 1-5 years of age were (38.7%). Fever (77.4%), pallor (74.1%), hepatosplenomegaly (41%) was the most common clinical feature noted in these patients. ALL (52.3%), followed by ITP (9.52%) was the most common etiology for bicytopenia. Aplastic anaemia (40%), megaloblastic anaemia (20%) were most common etiology noted for pancytopenia. Bicytopenia (67.7%) was more common than pancytopenia (32.2%).Peripheral smear examination picked up only 11 out of 14 cases of haematological malignancy, identified by bone marrow examination. Most common bone marrow finding noted was ALL (38.7%), followed by hypocellular bone marrow (22.5%).Conclusions: When there is high index of clinical suspicion and peripheral smear is unable to pick up these cases, it is advisable to do bone marrow examination at the earliest for early confirmation.

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Complementry Role of Bone Marrow Aspiration and Biopsy

10.47363/jpr/2021(3)130 ◽

2021 ◽

pp. 1-3

Author(s):

Nirali Shah ◽

◽

Vidhi Shah ◽

Falguni Goswami ◽

Roopam Gidwani ◽

...

Keyword(s):

Bone Marrow ◽

Tertiary Care ◽

Bone Marrow Aspiration ◽

Bone Marrow Examination ◽

Central Laboratory ◽

Tertiary Care Centre ◽

Hematological Disorders ◽

Complementary Role ◽

Important Diagnostic Tool

Introduction: Bone marrow examination is an important diagnostic tool to evaluate various hematological and non-hematological disorders. The two most important techniques used for the diagnosis are bone marrow aspiration and bone marrow biopsy which play complementary role with each other when performed simultaneously. Aims and Objectives: Study was done to compare the results of BMA and BMB and by that to prove the complementary role of both techniques to each other. Material and Methods: We evaluated total 74 cases in central laboratory, department of pathology, at tertiary care centre. All aspirations were stained by giemsa and iron stain while all biopsy were stained by routine H&E stain. Reticulin stain and IHC markers were used as and when required. Result: Out of total 74 cases, 40 cases showed positive corelation between these two techniques (54%). In two cases aspiration was not possible. In 8 cases biopsy was not done. 4 cases showed crushing artefact in BMB while 3 cases of aspiration were either diluted or dry tap. In all these cases diagnosis became possible by the alternate technique. BMB replaced BMA and vice versa as and when required. Conclusion: BMA and BMB are complementary procedure which yields extra support in diagnosing various hematological and non hematological disorders when one or other technique fails due to some reason

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