scholarly journals Supplementary material to "Novel method for determining <sup>234</sup>U-<sup>238</sup>U ages of Devils Hole 2 cave calcite"

2020 ◽  
Author(s):  
Xianglei Li ◽  
Kathleen A. Wendt ◽  
Yuri Dublyansky ◽  
Gina E. Moseley ◽  
Christoph Spötl ◽  
...  
Keyword(s):  
Devils Hole ◽  
Novel Method ◽  
Supplementary Material

USING BINDING PROFILES TO PREDICT BINDING SITES OF TARGET RNAs

2011 ◽  
Vol 09 (06) ◽  
pp. 697-713 ◽  
Author(s):  
UNYANEE POOLSAP ◽  
YUKI KATO ◽  
KENGO SATO ◽  
TATSUYA AKUTSU
Keyword(s):  
Binding Sites ◽  
Computational Cost ◽  
Computation Time ◽  
Rna Regulation ◽  
Antisense Rnas ◽  
Multiple Binding Sites ◽  
Multiple Binding ◽  
Novel Method ◽  
Supplementary Material ◽  
Rna Interaction

Prediction of RNA–RNA interaction is a key to elucidating possible functions of small non-coding RNAs, and a number of computational methods have been proposed to analyze interacting RNA secondary structures. In this article, we focus on predicting binding sites of target RNAs that are expected to interact with regulatory antisense RNAs in a general form of interaction. For this purpose, we propose bistaRNA, a novel method for predicting multiple binding sites of target RNAs. bistaRNA employs binding profiles that represent scores for hybridized structures, leading to reducing the computational cost for interaction prediction. bistaRNA considers an ensemble of equilibrium interacting structures and seeks to maximize expected accuracy using dynamic programming. Experimental results on real interaction data validate good accuracy and fast computation time of bistaRNA as compared with several competitive methods. Moreover, we aim to find new targets given specific antisense RNAs, which provides interesting insights into antisense RNA regulation. bistaRNA is implemented in C++. The program and Supplementary Material are available at .

scholarly journals Novel method for determining <sup>234</sup>U–<sup>238</sup>U ages of Devils Hole 2 cave calcite (Nevada)

Geochronology ◽  
2021 ◽  
Vol 3 (1) ◽  
pp. 49-58
Author(s):  
Xianglei Li ◽  
Kathleen A. Wendt ◽  
Yuri Dublyansky ◽  
Gina E. Moseley ◽  
Christoph Spötl ◽  
...  
Keyword(s):  
The Novel ◽  
Time Intervals ◽  
Δ13c Values ◽  
Devils Hole ◽  
Calcite Deposition ◽  
Dating Method ◽  
Novel Method ◽  
Multi Linear Regression ◽  
Δ18o And Δ13c

Abstract. Uranium–uranium (234U–238U) disequilibrium dating can determine the age of secondary carbonates over greater time intervals than the well-established 230Th–234U dating method. Yet it is rarely applied due to unknowns in the initial δ234U (δ234Ui) value, which result in significant age uncertainties. In order to understand the δ234Ui in Devils Hole 2 cave, Nevada, we have determined 110 δ234Ui values from phreatic calcite using 230Th–234U disequilibrium dating. The sampled calcite was deposited in Devils Hole 2 between 4 and 590 ka, providing a long-term look at δ234Ui variability over time. We then performed multi-linear regression among the δ234Ui values and correlative δ18O and δ13C values. The regression can be used to estimate the δ234Ui value of Devils Hole calcite based upon its measured δ18O and δ13C values. Using this approach and the measured present-day δ234U values of Devils Hole 2 calcite, we calculated 110 independent 234U–238U ages. In addition, we used newly measured δ18O, δ13C, and present-day δ234U values to calculate 10 234U–238U ages that range between 676 and 731 ka, thus allowing us to extend the Devils Hole chronology beyond the 230Th–234U-dated chronology while maintaining an age precision of ∼ 2 %. Our results indicate that calcite deposition at Devils Hole 2 cave began no later than 736 ± 11 kyr ago. The novel method presented here may be applied to future speleothem studies in similar hydrogeological settings, given appropriate calibration studies.

scholarly journals Deep Message Passing on Sets

2020 ◽  
Vol 34 (04) ◽  
pp. 5750-5757
Author(s):  
Yifeng Shi ◽  
Junier Oliva ◽  
Marc Niethammer
Keyword(s):  
Message Passing ◽  
Input Data ◽  
Relational Learning ◽  
Diffusion Dynamics ◽  
Novel Method ◽  
Supplementary Material ◽  
Real World Datasets ◽  
Residual Block ◽  
General Graphs ◽  
And Diffusion

Modern methods for learning over graph input data have shown the fruitfulness of accounting for relationships among elements in a collection. However, most methods that learn over set input data use only rudimentary approaches to exploit intra-collection relationships. In this work we introduce Deep Message Passing on Sets (DMPS), a novel method that incorporates relational learning for sets. DMPS not only connects learning on graphs with learning on sets via deep kernel learning, but it also bridges message passing on sets and traditional diffusion dynamics commonly used in denoising models. Based on these connections, we develop two new blocks for relational learning on sets: the set-denoising block and the set-residual block. The former is motivated by the connection between message passing on general graphs and diffusion-based denoising models, whereas the latter is inspired by the well-known residual network. In addition to demonstrating the interpretability of our model by learning the true underlying relational structure experimentally, we also show the effectiveness of our approach on both synthetic and real-world datasets by achieving results that are competitive with or outperform the state-of-the-art. For readers who are interested in the detailed derivations of serveral results that we present in this work, please see the supplementary material at: https://arxiv.org/abs/1909.09877.

Novel method for determining 234U-238U ages of Devils Hole 2 cave calcite (Nevada)

2021 ◽  
Author(s):  
Xianglei Li ◽  
Kathleen A. Wendt ◽  
Yuri Dublyansky ◽  
Gina E. Moseley ◽  
Christoph Spötl ◽  
...  
Keyword(s):  
Linear Regression ◽  
The Novel ◽  
Time Intervals ◽  
Devils Hole ◽  
Calcite Deposition ◽  
Dating Method ◽  
Novel Method ◽  
Multi Linear Regression ◽  
Over Time

&lt;p&gt;Uranium-uranium (&lt;sup&gt;234&lt;/sup&gt;U-&lt;sup&gt;238&lt;/sup&gt;U) disequilibrium dating can determine the age of secondary carbonates over greater time intervals than the well-established &lt;sup&gt;230&lt;/sup&gt;Th-&lt;sup&gt;234&lt;/sup&gt;U dating method. Yet it is rarely applied due to unknowns in the initial d&lt;sup&gt;234&lt;/sup&gt;U (d&lt;sup&gt;234&lt;/sup&gt;U&lt;sub&gt;i&lt;/sub&gt;) value, which result in significant age uncertainties. In order to understand the d&lt;sup&gt;234&lt;/sup&gt;U&lt;sub&gt;i&lt;/sub&gt; in Devils Hole 2 cave, Nevada, we have determined 110 d&lt;sup&gt;234&lt;/sup&gt;U&lt;sub&gt;i&lt;/sub&gt; values from phreatic calcite using &lt;sup&gt;230&lt;/sup&gt;Th-&lt;sup&gt;234&lt;/sup&gt;U disequilibrium dating. The sampled calcite was deposited in Devils Hole 2 between 4 and 590 ka, providing a long-term look at d&lt;sup&gt;234&lt;/sup&gt;U&lt;sub&gt;i&lt;/sub&gt; variability over time. We then performed multi-linear regression among the d&lt;sup&gt;234&lt;/sup&gt;U&lt;sub&gt;i&lt;/sub&gt; values and correlative d&lt;sup&gt;18&lt;/sup&gt;O and d&lt;sup&gt;13&lt;/sup&gt;C values. The regression can be used to estimate the d&lt;sup&gt;234&lt;/sup&gt;U&lt;sub&gt;i&lt;/sub&gt; value of Devils Hole calcite based upon its measured d&lt;sup&gt;18&lt;/sup&gt;O and d&lt;sup&gt;13&lt;/sup&gt;C values. Using this approach and the measured present-day d&lt;sup&gt;234&lt;/sup&gt;U values of Devils Hole 2 calcite, we calculated 110 independent &lt;sup&gt;234&lt;/sup&gt;U-&lt;sup&gt;238&lt;/sup&gt;U ages. In addition, we used newly measured d&lt;sup&gt;18&lt;/sup&gt;O, d&lt;sup&gt;13&lt;/sup&gt;C, and present-day d&lt;sup&gt;234&lt;/sup&gt;U values to calculate 10 &lt;sup&gt;234&lt;/sup&gt;U-&lt;sup&gt;238&lt;/sup&gt;U ages that range between 676 and 731 ka, thus allowing us to extend the Devils Hole chronology beyond the &lt;sup&gt;230&lt;/sup&gt;Th-&lt;sup&gt;234&lt;/sup&gt;U-dated chronology while maintaining an age precision of ~2 %. Our results indicate that calcite deposition at Devils Hole 2 cave began no later than 736 &amp;#177; 11 kyr ago. The novel method presented here may be applied to future speleothem studies in similar hydrogeological settings, given appropriate calibration studies.&lt;/p&gt;

scholarly journals Novel method for determining <sup>234</sup>U-<sup>238</sup>U ages of Devils Hole 2 cave calcite

2020 ◽  
Author(s):  
Xianglei Li ◽  
Kathleen A. Wendt ◽  
Yuri Dublyansky ◽  
Gina E. Moseley ◽  
Christoph Spötl ◽  
...  
Keyword(s):  
The Novel ◽  
Time Intervals ◽  
Devils Hole ◽  
Calcite Deposition ◽  
Dating Method ◽  
Novel Method ◽  
Linear Regressions ◽  
Over Time ◽  
Δ18o And Δ13c

Abstract. Uranium-uranium (234U-238U) dating can determine the age of secondary carbonates over greater time intervals than the well-established 230Th-234U dating method. Yet it is rarely applied due to unknowns surrounding the initial δ234U (δ234Ui) value, which result in significant age uncertainties. In order to understand the δ234Ui in Devils Hole 2 cave, we have precisely determined 110 δ234Ui values from phreatic calcite crusts using a 230Th-234U chronology. The sampled calcite crusts were deposited in Devils Hole 2 between 4 and 590 thousand years, providing a long-term look at δ234Ui variability over time. We then performed multi-linear regressions among the δ234Ui values and correlative δ18O and δ13C values. These regressions allow us to predict the δ234Ui value of Devils Hole calcite based upon its δ18O and δ13C. Using this approach and measured present-day &amp;felta;234U values, we calculate 110 independent 234U-238U ages of Devils Hole 2 cave deposits. In addition, we used newly measured δ18O, δ13C, and present-day δ234U values to calculate 10 234U-238U ages that range between 676 and 731 thousand years, thus allowing us to extend the Devils Hole chronology beyond the 230Th-234U-dated chronology while maintaining an age precision of ~2 %. Our results indicate that calcite deposition at Devils Hole 2 cave began no later than 736 &amp;pm; 11 thousand years ago. The novel method presented here may be used in future speleothem studies in similar hydrogeological settings, given appropriate calibration studies.

The removal and morphology of intact biofilms from implanted venous access devices

1995 ◽  
Vol 53 ◽  
pp. 1020-1021
Author(s):  
M.A. Gregory ◽  
G.P. Hadley
Keyword(s):  
Patient Selection ◽  
Surgical Oncology ◽  
Venous Access ◽  
Common Procedure ◽  
Indwelling Catheters ◽  
Careful Patient ◽  
Novel Method ◽  
The Subject ◽  
Vascular Catheters ◽  
Venous Access Devices

The insertion of implanted venous access systems for children undergoing prolonged courses of chemotherapy has become a common procedure in pediatric surgical oncology. While not permanently implanted, the devices are expected to remain functional until cure of the primary disease is assured. Despite careful patient selection and standardised insertion and access techniques, some devices fail. The most commonly encountered problems are colonisation of the device with bacteria and catheter occlusion. Both of these difficulties relate to the development of a biofilm within the port and catheter. The morphology and evolution of biofilms in indwelling vascular catheters is the subject of ongoing investigation. To date, however, such investigations have been confined to the examination of fragments of biofilm scraped or sonicated from sections of catheter. This report describes a novel method for the extraction of intact biofilms from indwelling catheters.15 children with Wilm’s tumour and who had received venous implants were studied. Catheters were removed because of infection (n=6) or electively at the end of chemotherapy.

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