In this chapter, we have focused on compression of medical images using integer wavelet transforms. Lifting transforms such as S, TS, S+P(B), S+P(C), 5/3, 2+@, 2, 9/7-M and 9/7-F transforms are used to evaluate the performances of lossless and lossy compression. Four medical images, namely, MRI, CT, ultrasound, and angiograms are used as test data sets. It is found from the experiments that, among the different transforms, the 9/7-M wavelet transform is identified as the optimal method for lossless and lossy compression of medical images.