scholarly journals Effects of Calcium Dobesilate on Visual Acuity and Macular Thickness in Nonproliferative Diabetic Retinopathy

2021 ◽  
Vol 20 (2) ◽  
pp. 62-66
Author(s):  
Sung Yeon Jun ◽  
Ji In Park ◽  
Joonhong Sohn ◽  
Daniel Duck-Jin Hwang
Keyword(s):  
Visual Acuity ◽  
Diabetic Retinopathy ◽  
Macular Thickness ◽  
Calcium Dobesilate ◽  
Nonproliferative Diabetic Retinopathy

scholarly journals Effect of Adding Losartan to Bevacizumab for Treating Diabetic Macular Edema

2020 ◽  
Vol 2020 ◽  
pp. 1-5
Author(s):  
Fariba Ghassemi ◽  
Abdulrahim Amini ◽  
Masoud Yasemi ◽  
Amin Nabavi ◽  
Mohammadkarim Johari
Keyword(s):  
Blood Pressure ◽  
Visual Acuity ◽  
Diabetic Retinopathy ◽  
Macular Edema ◽  
Diabetic Macular Edema ◽  
Glycosylated Hemoglobin ◽  
Macular Thickness ◽  
Central Macular Thickness ◽  
Nonproliferative Diabetic Retinopathy ◽  
Significant Difference

Introduction. Diabetic retinopathy is the most common cause of visual loss and blindness in the age group of 20 to 64 years. This study aimed to evaluate the efficacy of oral Losartan adjuvant therapy in combination with intravitreal injection of Bevacizumab in the treatment of diabetic macular edema. Methods. In this randomized clinical trial, 61 eyes of 47 patients with normal blood pressure and diabetic macular edema and nonproliferative diabetic retinopathy were studied. Patients were randomly divided into Losartan (n = 33) and control (n = 28) groups. All patients received 3–6 intravitreal injections of Bevacizumab over 6 months. General examination including blood pressure and glycosylated hemoglobin measurements were performed in all patients. Complete ophthalmologic examination and macular OCT were performed at the first, third, and sixth months of treatment in all patients. Results. The mean age of the patients studied was 57.1 ± 7.4 years and 37.7% of the patients were male. There was no significant difference between the two groups in terms of initial visual acuity, central macular thickness, and frequency of injections. There was no significant difference in visual acuity and central macular thickness between the two groups at the first, third, and sixth months of treatment. Age, frequency of injection, and initial macular thickness less than 450 microns were effective in patients’ final visual acuity. Conclusion. Short-term adjuvant treatment with Losartan in patients with diabetic macular edema and nonproliferative diabetic retinopathy has no greater effect than the standard treatment.

scholarly journals Quantitative analysis of optical coherence tomography angiography metrics in diabetic retinopathy

2020 ◽  
Vol 12 ◽  
pp. 251584141989745 ◽  
Author(s):  
Hamid Safi ◽  
Pasha Anvari ◽  
Dariush Naseri ◽  
Hamideh Shenazandi ◽  
Pegah Kazemi ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Visual Acuity ◽  
Diabetic Retinopathy ◽  
Optical Coherence Tomography Angiography ◽  
Macular Thickness ◽  
Foveal Avascular Zone ◽  
Central Macular Thickness ◽  
Optical Coherence ◽  
Ellipsoid Zone ◽  
Avascular Zone

Purpose: To evaluate the correlation of the visual acuity and diabetic retinopathy stage using optical coherence tomography and optical coherence tomography angiography metrics. Methods: In this prospective study, optical coherence tomography and optical coherence tomography angiography images of patients with different stages of diabetic retinopathy were obtained. In optical coherence tomography angiography images, the size of foveal avascular zone, central macular thickness, and vessel density at superficial and deep capillary layers of the macula were measured. In optical coherence tomography images, the presence of intraretinal cyst, disorganization of retinal inner layer, and ellipsoid zone and external limiting membrane disruption were evaluated. The associations between the variables with visual acuity and diabetic retinopathy stage were analyzed. Results: In total, 68 eyes of 38 patients with a mean age of 58.96 ± 10.59 years were included. In total, 34 eyes were categorized as non-proliferative diabetic retinopathy, 14 as active, and 20 as regressed proliferative diabetic retinopathy. Univariate analysis showed deep parafoveal vessel density, central macular thickness, ellipsoid zone disruption, disorganization of retinal inner layer, and external limiting membrane disruption had a significant relationship with visual acuity. However, in multivariate analysis, only central macular thickness and ellipsoid zone disruption had significant association with visual acuity ( p = 0.02 and p = 0.01, respectively). There was a significant difference in deep parafoveal vessel density ( p = 0.04), but not in foveal avascular zone area, between different stages of diabetic retinopathy. Conclusion: In this study, the foveal avascular zone area did not correlate with visual acuity and different stages of diabetic retinopathy. Structural abnormalities on optical coherence tomography images with especial focus on outer retinal disruption provided more reliable predictors for visual acuity outcomes in patients with diabetic retinopathy.

The Effect of Calcium Dobesilate on Nonproliferative Diabetic Retinopathy: A Controlled Study

Ophthalmology ◽  
1978 ◽  
Vol 85 (6) ◽  
pp. 594-606 ◽  
Author(s):  
Robert L. Stamper ◽  
Morton E. Smith ◽  
Samuel B. Aronson ◽  
John C. Cavender ◽  
Gilbert W. Cleasby ◽  
...  
Keyword(s):  
Diabetic Retinopathy ◽  
Controlled Study ◽  
Calcium Dobesilate ◽  
Nonproliferative Diabetic Retinopathy

scholarly journals The relationship between perifoveal capillary ring alterations and visual acuity in diabetic retinopathy

2021 ◽  
pp. 3-3
Author(s):  
Nenad Petrovic ◽  
Dusan Todorovic ◽  
Suncica Sreckovic ◽  
Tatjana Sarenac-Vulovic ◽  
Svetlana Jovanovic ◽  
...  
Keyword(s):  
Visual Acuity ◽  
Diabetic Retinopathy ◽  
Proliferative Diabetic Retinopathy ◽  
Macular Thickness ◽  
Capillary Network ◽  
Significant Difference ◽  
The Impact ◽  
Perifoveal Capillary Network ◽  
Decrease In Visual Acuity ◽  
Macular Ischemia

Background / Aim. To investigate the impact of diabetic macular ischemia (DMI) on visual acuity (VA) through the analysis of perifoveal capillary network in various stages of diabetic retinopathy (Non Proliferative Diabetic Retinopathy-NPDR and Proliferative Diabetic Retinopathy-PDR). Methods. Qualitative and quantitative analysis of 143 angiograms of patients with different stages of diabetic retinopathy was performed. The degree of macular ischemia was assessed by the analysis of 2 parameters: perifoveal capillary ring i.e. Foveal avascular zone (FAZ) outline irregularity and capillary loss. Finally, a comparison was made between the degree of macular ischemia with the best corrected visual acuity, depending on macular thickness. Results. In the eyes with mild and moderate NPDR, without significant macular thickening, no statistically significant decrease of visual acuity, caused by macular ischemia, was noticed (p=0.81). Opposite, in subgroup with severe NPDR and PDR, without significant macular thickening, statistically significant difference was presented among eyes with moderate and severe macular ischemia comparing to eyes with lower grades of macular ischemia (p=0.021, p=0.018). In eyes with moderate NPDR and mild macular ischemia, the increase in macular thickness resulted in a statistically insignificant decrease in visual acuity compared to eyes with normal macular thickness (p=0.088). But in eyes with severe NPDR, any pathological increase in macular thickness caused a statistically significant decrease in visual acuity, regardless of the degree of macular ischemia (p=0.018-0.040). A similar relationship was also found in eyes with PDR (p=0.017-0.042). In eyes with statistically significant decrease of visual acuity, the most of the examined eyes (98%) had FAZ outline irregularity in nasal perifoveal subfield. Conclusion. In the absence of significant macular thickening, destruction of one-half of the perifoveal capillary network or greater is associated with reduced VA. The location of macular ischemic changes in the nasal parts of the perifoveal capillary ring plays a crucial role in its effects on visual function.

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