Correlation between choroidal thickness and central macular thickness measured by optical coherence tomography in nonproliferative diabetic retinopathy

2018 ◽  
Vol 19 (3) ◽  
pp. 201
Author(s):  
MohamedA Hamed ◽  
Nehal Adel Hasan ◽  
AhmedH Aldghaimy ◽  
AlshaimaaM Eltaher
Keyword(s):  
Optical Coherence Tomography ◽  
Diabetic Retinopathy ◽  
Choroidal Thickness ◽  
Macular Thickness ◽  
Central Macular Thickness ◽  
Optical Coherence ◽  
Nonproliferative Diabetic Retinopathy

scholarly journals Quantitative analysis of optical coherence tomography angiography metrics in diabetic retinopathy

2020 ◽  
Vol 12 ◽  
pp. 251584141989745 ◽  
Author(s):  
Hamid Safi ◽  
Pasha Anvari ◽  
Dariush Naseri ◽  
Hamideh Shenazandi ◽  
Pegah Kazemi ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Visual Acuity ◽  
Diabetic Retinopathy ◽  
Optical Coherence Tomography Angiography ◽  
Macular Thickness ◽  
Foveal Avascular Zone ◽  
Central Macular Thickness ◽  
Optical Coherence ◽  
Ellipsoid Zone ◽  
Avascular Zone

Purpose: To evaluate the correlation of the visual acuity and diabetic retinopathy stage using optical coherence tomography and optical coherence tomography angiography metrics. Methods: In this prospective study, optical coherence tomography and optical coherence tomography angiography images of patients with different stages of diabetic retinopathy were obtained. In optical coherence tomography angiography images, the size of foveal avascular zone, central macular thickness, and vessel density at superficial and deep capillary layers of the macula were measured. In optical coherence tomography images, the presence of intraretinal cyst, disorganization of retinal inner layer, and ellipsoid zone and external limiting membrane disruption were evaluated. The associations between the variables with visual acuity and diabetic retinopathy stage were analyzed. Results: In total, 68 eyes of 38 patients with a mean age of 58.96 ± 10.59 years were included. In total, 34 eyes were categorized as non-proliferative diabetic retinopathy, 14 as active, and 20 as regressed proliferative diabetic retinopathy. Univariate analysis showed deep parafoveal vessel density, central macular thickness, ellipsoid zone disruption, disorganization of retinal inner layer, and external limiting membrane disruption had a significant relationship with visual acuity. However, in multivariate analysis, only central macular thickness and ellipsoid zone disruption had significant association with visual acuity ( p = 0.02 and p = 0.01, respectively). There was a significant difference in deep parafoveal vessel density ( p = 0.04), but not in foveal avascular zone area, between different stages of diabetic retinopathy. Conclusion: In this study, the foveal avascular zone area did not correlate with visual acuity and different stages of diabetic retinopathy. Structural abnormalities on optical coherence tomography images with especial focus on outer retinal disruption provided more reliable predictors for visual acuity outcomes in patients with diabetic retinopathy.

scholarly journals Evaluation of Intravital Ranibizumab on Proliferative Diabetic Retinopathy with Macular Edema by Optical Coherence Tomography Angiography

2020 ◽  
pp. 14-25
Author(s):  
Mona Abdelkader ◽  
Hamza Abdelhamed ◽  
Ebtihal Abdelaziz ◽  
Amr Abdelkader
Keyword(s):  
Optical Coherence Tomography ◽  
Diabetic Retinopathy ◽  
Macular Edema ◽  
Proliferative Diabetic Retinopathy ◽  
Optical Coherence Tomography Angiography ◽  
Macular Thickness ◽  
Central Macular Thickness ◽  
Optical Coherence ◽  
Swept Source ◽  
Treatment Regimens

Purpose: To evaluate the effect of ranibizumab by Optical Coherence Tomography Angiography (OCTA)in proliferative diabetic retinopathy (PDR) with macular edema and to evaluate the role of Swept Source Optical Coherence Tomography Angiography in detection and characterization of new vessels at the disc (NVD) and new vessels elsewhere (NVE). Subjects and Method: The study included patients with proliferative diabetic retinopathy (PDR) and clinically significant diabetic macular edema. Patients with central macular thickness (CMT) above 300 μm underwent intravitreal injection of 0.5 mg Ranibizumab& those having CMT below 300μm had laser treatment. Results: The study was conducted on 50 cases with proliferative diabetic retinopathy with macular edema There was significant increase in best corrected visual acuity (BCVA) across time of treatment. Mean (±SD) BCVA at diagnosis, at 1monthat 3 month were 9.1±0.1, 0.8±0.1, 0.7±0.2. respectively (p<0.001) Central macular thickness (CMT); Area of neovascularization (ArNV); Exuberant Vascular Proliferation (EVP)showed significant decrease across time of treatment, Conclusion: ranibizumab injections are a safe and effective alternative to Pan retinal photocoagulation for the management of PDR. OCTA is useful to monitor different NVD subtypes, their development, and the efficacy of treatment regimens as well as to define new vessel morphological details. Small scan size delineates minute morphology of NVD and misses extension of lesions beyond disc margin, while larger scan size masks fine details.

scholarly journals Central Macular Thickness: a Comparative Study of Diabetics Vs Healthy

2019 ◽  
Vol 35 (1) ◽  
Author(s):  
Beenish Khan, Muhammad Muneer Quraishy, Asma Shams
Keyword(s):  
Optical Coherence Tomography ◽  
Diabetic Retinopathy ◽  
Macular Thickness ◽  
Diabetic Group ◽  
Central Macular Thickness ◽  
Optical Coherence ◽  
Healthy Group ◽  
Department Of Ophthalmology ◽  
Significant Difference ◽  
Patients With Diabetes

Purpose: To compare the central macular thickness amongst diabetics with that of healthy population by using Optical Coherence Tomography. Study Design: Case control study. Place and Duration of Study: Department of Ophthalmology Unit I, Civil Hospital Karachi from 5th March 2012 to 4th September 2012. Material and Methods: We randomly selected patients with diabetes (cases) and healthy patients (control) with clinically normal macula and no diabetic retinopathy. Detailed relevant history was acquired. Best corrected visual acuity (BCVA) was measured with standard Snellen’s chart. Detailed dilated fundus examination was done using +90D and +78D lens. Central macular thickness within an area of 1000 µm was measured using Optical Coherence Tomography. Results: There were 68 patients in each group. The mean age of patients in the Diabetic group was 47.94 ± 14 (20-80) years and in the healthy group it was found to be 39.53 ± 14.93 (20-80) years. Out of these 26 were male and 42 were female in the diabetic group whereas 27 were male and 41 were female in the healthy group. Mean central macular thickness of Diabetic eyes were 214.48 ± 31.41 µm and that of healthy eyes were 236.79 ± 19.38 µm with mean difference of 22.31 ± 4 µm (p value = 0.000).. A statistically significant difference in the central macular thickness of Diabetics and healthy patients was observed. Conclusion: The central macular thickness is significantly decreased in eyes of patients with Diabetes. Keywords: Central macular thickness, Optical Coherence Tomography, OCT, Diabetic Retinopathy, Diabetic Maculopathy.

scholarly journals Inter-relationship between retinal and choroidal vasculatures using optical coherence tomography angiography in normal eyes

2018 ◽  
Vol 30 (1) ◽  
pp. 48-57 ◽  
Author(s):  
Jaeryung Oh ◽  
Daniel Jinhag Baik ◽  
Jaemoon Ahn
Keyword(s):  
Optical Coherence Tomography ◽  
Layer Thickness ◽  
Optical Coherence Tomography Angiography ◽  
Macular Thickness ◽  
Vascular Density ◽  
Inner Plexiform Layer ◽  
Central Macular Thickness ◽  
Optical Coherence ◽  
Outer Retina ◽  
Capillary Plexus

Purpose: To quantify vascular and structural macular variables in healthy eyes and to investigate correlations between these variables and age using optical coherence tomography angiography. Materials and methods: A total of 261 eyes of 261 subjects with normal fundus were included. Central macular thickness, ganglion cell layer to inner plexiform layer thickness, outer retina layer thickness, subfoveal choroidal thickness, and choroidal vascularity index were measured using optical coherence tomography. Foveal avascular zone area, vascular density, and flow void area were measured using optical coherence tomography angiography. Results: Vascular density in the superficial capillary plexus was correlated with central macular thickness, ganglion cell layer to inner plexiform layer thickness, and outer retina layer thickness ( P < 0.001, P = 0.004, and P < 0.001, respectively). Vascular density in the deep capillary plexus was correlated with central macular thickness and outer retina layer thickness ( P = 0.003 and P = 0.001, respectively). Vascular density of choriocapillaris was correlated with vascular density of superficial capillary plexus and deep capillary plexus ( P < 0.001 and P = 0.001, respectively). Conclusion: Vascular density of choriocapillaris varies with retinal vascular density rather than the structure of choroid using optical coherence tomography angiography. In contrast, retinal vascular density changes as the retinal structure. Our results provide more information about the relationship between retina and choroid.

scholarly journals Central Macular Thickness in a Healthy Mexican Population Using Huvitz Optical Coherence Tomography

2020 ◽  
Vol Volume 14 ◽  
pp. 3931-3940
Author(s):  
Renata García-Franco ◽  
Dalia Méndez-Marín ◽  
Marlon García-Roa ◽  
Paulina Ramirez-Neria ◽  
Diego Valera-Cornejo ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Macular Thickness ◽  
Mexican Population ◽  
Central Macular Thickness ◽  
Optical Coherence

scholarly journals Central Macular Thickness in Children with Myopia, Emmetropia, and Hyperopia: An Optical Coherence Tomography Study

2015 ◽  
Vol 2015 ◽  
pp. 1-4 ◽  
Author(s):  
Gordon S. K. Yau ◽  
Jacky W. Y. Lee ◽  
Tiffany T. Y. Woo ◽  
Raymond L. M. Wong ◽  
Ian Y. H. Wong
Keyword(s):  
Optical Coherence Tomography ◽  
Axial Length ◽  
Retinal Nerve Fibre Layer ◽  
Macular Thickness ◽  
Chinese Children ◽  
Central Macular Thickness ◽  
Optical Coherence ◽  
The Mean ◽  
Nerve Fibre Layer ◽  
Chinese Subjects

Purpose.To investigate the central macular thickness (CMT) in myopic, emmetropic, and hyperopic Chinese children using Optical Coherence Tomography.Methods.168 right eyes of Chinese subjects aged 4–18 were divided into 3 groups based on their postcycloplegic spherical equivalent: myopes (<−1.0 D); emmetropes (≥−1.0 to ≤+1.0 D); and hyperopes (>+1.0 D) and the CMT was compared before/after age adjustment. The CMT was correlated with age, axial length, and peripapillary retinal nerve fibre layer (RNFL).Results.The mean CMT was274.9±50.3 μm and the mean population age was7.6±3.3years. The CMT was thickest in the myopes (283.3±57.3 μm,n=56), followed by the hyperopes (266.2±55.31 μm,n=60) and then emmetropes (259.8±28.7 μm,n=52) (allP<0.0001). When adjusted for age, myopes had a thicker CMT than the other 2 groups (allP<0.0001) but there was no CMT difference between the emmetropes and hyperopes (P>0.05). There was no significant correlation between CMT with age, axial length, or peripapillary RNFL (allP≥0.2).Conclusion.Chinese children with myopia had a thicker CMT than those with emmetropia or hyperopia. There was no correlation of the CMT with age, axial length, or peripapillary RNFL thickness.

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