Efficiency of N-Nitro L-Arginine Methyl Ester Treatment on Experimentally Acute Lung Injury Occurred with Bilateral Blunt Chest Trauma Model on Rabbits

2015 ◽  
Vol 16 (1) ◽  
pp. 1-7
Author(s):  
Şerife ÖZDİNÇ ◽  
M. Ertuğrul KAFALI ◽  
Hasan KARA ◽  
Hatice TOY ◽  
Başar CANDER ◽  
...  
Keyword(s):  
Acute Lung Injury ◽  
Methyl Ester ◽  
Lung Injury ◽  
Blunt Chest Trauma ◽  
Chest Trauma ◽  
Trauma Model

ACTIVATION AND RECRUITMENT OF POLYMORPHONUCLEAR GRANULOCYTES DURING ACUTE LUNG INJURY FOLLOWING BLUNT CHEST TRAUMA

Shock ◽  
2006 ◽  
Vol 25 (Supplement 1) ◽  
pp. 24
Author(s):  
M.W. Kn??ferl ◽  
F. Gebhard ◽  
M. Kieninger ◽  
D.H. Seitz ◽  
S.T. Braum??ller ◽  
...  
Keyword(s):  
Acute Lung Injury ◽  
Lung Injury ◽  
Blunt Chest Trauma ◽  
Chest Trauma ◽  
Polymorphonuclear Granulocytes

scholarly journals Role of Complement C5 in Experimental Blunt Chest Trauma-Induced Septic Acute Lung Injury (ALI)

PLoS ONE ◽  
2016 ◽  
Vol 11 (7) ◽  
pp. e0159417 ◽  
Author(s):  
Miriam Kalbitz ◽  
Michael Karbach ◽  
Sonja Braumueller ◽  
Philipp Kellermann ◽  
Florian Gebhard ◽  
...  
Keyword(s):  
Acute Lung Injury ◽  
Lung Injury ◽  
Blunt Chest Trauma ◽  
Chest Trauma

Cytokine productive capacity of alveolar macrophages and Kupffer cells after femoral fracture and blunt chest trauma in a murine trauma model

2013 ◽  
Vol 152 (2) ◽  
pp. 159-166 ◽  
Author(s):  
Claudia Neunaber ◽  
Stefanie Oestern ◽  
Hagen Andruszkow ◽  
Christian Zeckey ◽  
Philipp Mommsen ◽  
...  
Keyword(s):  
Kupffer Cells ◽  
Alveolar Macrophages ◽  
Femoral Fracture ◽  
Blunt Chest Trauma ◽  
Chest Trauma ◽  
Productive Capacity ◽  
Trauma Model

Quantitation and pattern of parenchymal lung injury in blunt chest trauma diagnostic and therapeutic implications

1988 ◽  
Vol 12 (4) ◽  
pp. 270-281 ◽  
Author(s):  
Robert B. Wagner ◽  
William O. Crawford ◽  
Patrick P. Schimpf ◽  
Peter M. Jamieson ◽  
Krishna C.V.G. Rao
Keyword(s):  
Lung Injury ◽  
Blunt Chest Trauma ◽  
Chest Trauma ◽  
Therapeutic Implications ◽  
Parenchymal Lung

Inhibition of nitric oxide synthase attenuates NNMU-induced alveolar injury in vivo

1997 ◽  
Vol 273 (6) ◽  
pp. L1167-L1173 ◽  
Author(s):  
Wilhelm S. Cruz ◽  
Michael A. Moxley ◽  
John A. Corbett ◽  
William J. Longmore
Keyword(s):  
Nitric Oxide ◽  
Acute Lung Injury ◽  
Methyl Ester ◽  
Lung Injury ◽  
Protein Ratio ◽  
Nos Inhibitors ◽  
Elevated Expression ◽  
Nos Inhibitor ◽  
Oxide Synthase

The purpose of this study was to determine if the acute alveolar injury induced by subcutaneous injections of N-nitroso- N-methylurethane (NNMU) in rats is mediated by nitric oxide (NO ⋅). We show that intraperitoneal injections of the NO ⋅ synthase (NOS) inhibitor N ω-nitro-l-arginine methyl ester (l-NAME) or aminoguanidine significantly attenuate the NNMU-induced alveolar injury as assessed by 1) normalization of the alveolar-arterial O2difference, 2) attenuation of the lowered phospholipid-to-protein ratio in the crude surfactant pellet (CSP), 3) attenuation of the elevated minimal surface tension of the CSP, and 4) attenuation of polymorphonuclear neutrophilic infiltration into the alveolar space. Injections of N ω-nitro-d-arginine methyl ester, the inactive stereoisoform ofl-NAME, did not affect the acute lung injury. Western blot analysis of whole lung homogenates demonstrate an elevated expression of transcriptionally inducible, Ca2+-independent NOS (iNOS) in NNMU-injected rats compared with control saline-injected rats. NOS inhibitors did not affect NNMU-induced iNOS expression. These investigations demonstrate that the inhibition of NOS attenuates NNMU-induced acute lung injury, suggesting a role for NO ⋅ in the progression of acute respiratory distress syndrome.

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