scholarly journals Overexpression of bone morphogenetic protein 2 through aberrant canonical Wnt/β-catenin signaling pathway plays an important role in heterotopic ossification of adrenal myelolipoma

2014 ◽  
Vol 8 (1-2) ◽  
pp. 104 ◽  
Author(s):  
Yozo Mitsui ◽  
Hiroaki Yasumoto ◽  
Miho Hiraki ◽  
Naoko Arichi ◽  
Noriyoshi Ishikawa ◽  
...  
Keyword(s):  
Bone Formation ◽  
Heterotopic Ossification ◽  
Bone Morphogenetic Protein ◽  
Signaling Pathway ◽  
Bone Morphogenetic Protein 2 ◽  
Heterotopic Bone ◽  
Heterotopic Bone Formation ◽  
Adrenal Myelolipoma ◽  
Morphogenetic Protein ◽  
Canonical Wnt

The precise mechanism of heterotopic ossification caused by several types of tumours is largely unknown. However, recent studies have indicated that bone morphogenetic protein 2 (BMP2) is closely linked to the Wnt/β-catenin signaling pathway in this rare phenomenon of bone formation. We report a rare case of adrenal myelolipoma (ML) in a 27-year-old woman with heterotopic bone formation. Immunohistochemical findings showed BMP2 expression in the cytoplasm of tumour cells, as well as the matrix adjacent to newly developed bone tissue. In addition, β-catenin was prominent in the cytoplasm and nuclei of BMP2-positive tumour cells. To the best of our knowledge, this is the first report of adrenal ML showing heterotopic ossification with accelerated expression of both BMP2 and β-catenin. Our case findings indicate that BMP2 overexpression via aberrant canonical Wnt/β-catenin signaling may contribute to heterotopic bone formation occurring in adrenal ML.

scholarly journals Imaging symptomatic bone morphogenetic protein-2–induced heterotopic bone formation within the spinal canal: case report

2016 ◽  
Vol 24 (5) ◽  
pp. 857-861 ◽  
Author(s):  
Timothy Chryssikos ◽  
Kenneth M. Crandall ◽  
Charles A. Sansur
Keyword(s):  
Bone Formation ◽  
Bone Morphogenetic Protein ◽  
Spinal Canal ◽  
Imaging Techniques ◽  
Cauda Equina ◽  
Plain Film ◽  
Bone Morphogenetic Protein 2 ◽  
Heterotopic Bone ◽  
Heterotopic Bone Formation ◽  
Morphogenetic Protein

Heterotopic bone formation within the spinal canal is a known complication of bone morphogenetic protein–2 (BMP-2) and presents a clinical and surgical challenge. Imaging modalities are routinely used for operative planning in this setting. Here, the authors present the case of a 59-year-old woman with cauda equina syndrome following intraoperative BMP-2 administration. Plain film myelographic studies showed a region of severe stenosis that was underappreciated on CT myelography due to a heterotopic bony lesion mimicking the dorsal aspect of a circumferentially patent thecal sac. When evaluating spinal stenosis under these circumstances, it is important to carefully consider plain myelographic images in addition to postmyelography CT images as the latter may underestimate the true degree of stenosis due to the potentially similar radiographic appearances of evolving BMP-2–induced heterotopic bone and intrathecal contrast. Alternatively, comparison of sequentially acquired noncontrast CT scans with CT myelographic images may also assist in distinguishing BMP-2–induced heterotopic bony lesions from the thecal sac. Further studies are needed to elucidate the roles of the available imaging techniques in this setting and to characterize the connection between the radiographic and histological appearances of BMP-2–induced heterotopic bone.

scholarly journals Bone morphogenetic protein-induced heterotopic bone formation: What have we learned from the history of a half century?

2015 ◽  
Vol 51 (2) ◽  
pp. 42-50 ◽  
Author(s):  
Takenobu Katagiri ◽  
Kenji Osawa ◽  
Sho Tsukamoto ◽  
Mai Fujimoto ◽  
Arei Miyamoto ◽  
...  
Keyword(s):  
Bone Formation ◽  
Bone Morphogenetic Protein ◽  
Heterotopic Bone ◽  
Heterotopic Bone Formation ◽  
Half Century ◽  
Morphogenetic Protein ◽  
History Of

scholarly journals Heparin-mediated delivery of bone morphogenetic protein-2 improves spatial localization of bone regeneration

2020 ◽  
Vol 6 (1) ◽  
pp. eaay1240 ◽  
Author(s):  
Marian H. Hettiaratchi ◽  
Laxminarayanan Krishnan ◽  
Tel Rouse ◽  
Catherine Chou ◽  
Todd C. McDevitt ◽  
...  
Keyword(s):  
Bone Formation ◽  
Heterotopic Ossification ◽  
Bone Morphogenetic Protein ◽  
Spatial Localization ◽  
Bone Defects ◽  
Bone Morphogenetic Protein 2 ◽  
Morphogenetic Protein ◽  
Large Bone ◽  
Large Bone Defects

Supraphysiologic doses of bone morphogenetic protein-2 (BMP-2) are used clinically to promote bone formation in fracture nonunions, large bone defects, and spinal fusion. However, abnormal bone formation (i.e., heterotopic ossification) caused by rapid BMP-2 release from conventional collagen sponge scaffolds is a serious complication. We leveraged the strong affinity interactions between heparin microparticles (HMPs) and BMP-2 to improve protein delivery to bone defects. We first developed a computational model to investigate BMP-2–HMP interactions and demonstrated improved in vivo BMP-2 retention using HMPs. We then evaluated BMP-2–loaded HMPs as a treatment strategy for healing critically sized femoral defects in a rat model that displays heterotopic ossification with clinical BMP-2 doses (0.12 mg/kg body weight). HMPs increased BMP-2 retention in vivo, improving spatial localization of bone formation in large bone defects and reducing heterotopic ossification. Thus, HMPs provide a promising opportunity to improve the safety profile of scaffold-based BMP-2 delivery.

scholarly journals β-Catenin Signaling Pathway Is Crucial for Bone Morphogenetic Protein 2 to Induce New Bone Formation

2006 ◽  
Vol 282 (1) ◽  
pp. 526-533 ◽  
Author(s):  
Yan Chen ◽  
Heather C. Whetstone ◽  
Andrew Youn ◽  
Puviindran Nadesan ◽  
Edwin C. Y. Chow ◽  
...  
Keyword(s):  
Bone Formation ◽  
Bone Morphogenetic Protein ◽  
Signaling Pathway ◽  
Bone Morphogenetic Protein 2 ◽  
New Bone Formation ◽  
Morphogenetic Protein

Evaluation of Heterotopic Bone Formation Induced by Squalane and Bone Morphogenetic Protein Composite

1997 ◽  
Vol 337 ◽  
pp. 261-266 ◽  
Author(s):  
Toshiyuki Kawakami ◽  
Tatsushi Kawai ◽  
Noriyuki Takei ◽  
Toshihiko Kise ◽  
Shigeo Eda ◽  
...  
Keyword(s):  
Bone Formation ◽  
Bone Morphogenetic Protein ◽  
Heterotopic Bone ◽  
Heterotopic Bone Formation ◽  
Morphogenetic Protein
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