In vitro Cytotoxicity of Hibiscus sabdariffa Linn Extracts on A549 Lung Cancer Cell Line

2020 ◽  
Vol 12 (1) ◽  
pp. 14-19 ◽  
Author(s):  
Qotrunnada Fithrotunnisa ◽  
Ade Arsianti ◽  
Gerry Kurniawan ◽  
Fona Qorina ◽  
Nadzila Anindya Tejaputri ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cell Line ◽  
Cancer Cell Line ◽  
In Vitro Cytotoxicity ◽  
Lung Cancer Cell Line ◽  
Hibiscus Sabdariffa ◽  
Lung Cancer Cell ◽  
A549 Lung Cancer Cell ◽  
A549 Lung

Cisplatin cytotoxicity is enhanced with zoledronic acid in A549 lung cancer cell line: Preliminary results of an in vitro study

2007 ◽  
Vol 31 (9) ◽  
pp. 1069-1071 ◽  
Author(s):  
O.H. Ozturk ◽  
H. Bozcuk ◽  
D. Burgucu ◽  
D. Ekinci ◽  
M. Ozdogan ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Zoledronic Acid ◽  
Cell Line ◽  
Cancer Cell Line ◽  
In Vitro Study ◽  
Lung Cancer Cell Line ◽  
Lung Cancer Cell ◽  
A549 Lung Cancer Cell ◽  
A549 Lung

scholarly journals Biosynthesized silver nanoparticles using Caulerpa taxifolia against A549 lung cancer cell line through cytotoxicity effect/morphological damage

2020 ◽  
Vol 27 (12) ◽  
pp. 3421-3427 ◽  
Author(s):  
Danjie Zhang ◽  
Govindan Ramachandran ◽  
Ramzi A. Mothana ◽  
Nasir A. Siddiqui ◽  
Riaz Ullah ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Silver Nanoparticles ◽  
Cell Line ◽  
Cancer Cell ◽  
Cancer Cell Line ◽  
Lung Cancer Cell Line ◽  
Caulerpa Taxifolia ◽  
Lung Cancer Cell ◽  
A549 Lung Cancer Cell ◽  
A549 Lung

scholarly journals RETRACTED ARTICLE: Synthesis, characterization and in vitro studies of doxorubicin-loaded magnetic nanoparticles grafted to smart copolymers on A549 lung cancer cell line

2012 ◽  
Vol 10 (1) ◽  
Author(s):  
Abolfazl Akbarzadeh ◽  
Mohammad Samiei ◽  
Sang Woo Joo ◽  
Maryam Anzaby ◽  
Younes Hanifehpour ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Magnetic Nanoparticles ◽  
Cancer Cell Line ◽  
Covalent Bonding ◽  
Lung Cancer Cell Line ◽  
Magnetic Nanocomposites ◽  
Lung Cancer Cell ◽  
A549 Lung Cancer Cell ◽  
A549 Lung

Abstract Background The aim of present study was to develop the novel methods for chemical and physical modification of superparamagnetic iron oxide nanoparticles (SPIONs) with polymers via covalent bonding entrapment. These modified SPIONs were used for encapsulation of anticancer drug doxorubicin. Method At first approach silane–grafted magnetic nanoparticles was prepared and used as a template for polymerization of the N-isopropylacrylamide (NIPAAm) and methacrylic acid (MAA) via radical polymerization. This temperature/pH-sensitive copolymer was used for preparation of DOX–loaded magnetic nanocomposites. At second approach Vinyltriethoxysilane-grafted magnetic nanoparticles were used as a template to polymerize PNIPAAm-MAA in 1, 4 dioxan and methylene-bis-acrylamide (BIS) was used as a cross-linking agent. Chemical composition and magnetic properties of Dox–loaded magnetic hydrogel nanocomposites were analyzed by FT-IR, XRD, and VSM. Results The results demonstrate the feasibility of drug encapsulation of the magnetic nanoparticles with NIPAAm–MAA copolymer via covalent bonding. The key factors for the successful prepardtion of magnetic nanocomposites were the structure of copolymer (linear or cross-linked), concentration of copolymer and concentration of drug. The influence of pH and temperature on the release profile of doxorubicin was examined. The in vitro cytotoxicity test (MTT assay) of both magnetic DOx–loaded nanoparticles was examined. The in vitro tests showed that these systems are no toxicity and are biocompatible. Conclusion IC50 of DOx–loaded Fe3O4 nanoparticles on A549 lung cancer cell line showed that systems could be useful in treatment of lung cancer.

Sign in / Sign up

Export Citation Format

Share Document