Preliminary Study of the Antiemetic Effect of Garcinia Kola Seed Extract in Young Chicks

10.5580/204c ◽  
2010 ◽  
Vol 8 (2) ◽  
Keyword(s):  
Seed Extract ◽  
Antiemetic Effect ◽  
Garcinia Kola ◽  
Preliminary Study ◽  
Young Chicks

Kolaviron and Garcinia kola Seed Extract Protect Against Ischaemia/Reperfusion Injury on Isolated Rat Heart

Drug Research ◽  
2018 ◽  
Vol 68 (05) ◽  
pp. 286-295
Author(s):  
Ademola Oyagbemi ◽  
Dirk Bester ◽  
Johan Esterhuyse ◽  
Ebenezer Farombi
Keyword(s):  
Reperfusion Injury ◽  
Rat Heart ◽  
Caspase 3 ◽  
Isolated Rat Heart ◽  
Seed Extract ◽  
Parp Cleavage ◽  
Control Group ◽  
Ischaemia Reperfusion Injury ◽  
Garcinia Kola ◽  
Isolated Rat

Abstract Background The incidence of cardiovascular diseases and its associated complications have increased greatly in the past three decades. The purpose of this study was to evaluate the acute cardioprotective effects of Garcinia kola (GK) seed extract and Kolaviron (KV) and determine mechanisms of action involving RISK signalling pathways. Methods Male Wistar rats were used in this study. Hearts were excised and mounted on the Langendorff perfusion system. The control, group 1 was perfused with dimethyl sulfoxide (DMSO), group II with KV and group III with GK respectively. Western blot analyses were performed on frozen heart tissues. Results Isolated rat hearts perfused with KV and GK attenuated apoptotic pathways with significant reduction in p38 MAPK protein phosphorylation, as well as reduction in total caspase 3, cleaved caspase 3 (Asp 175) and PARP cleavage. KV and GK also down-regulated p-JNK1 (Tyr 185) and p-JNK 2 (Thr 183) protein expression at the 10 min reperfusion time ponit. Cardioprotection was achieved in part, by enhancement of the reperfusion injury signalling kinase (RISK) pathway; as evidenced by significant increases in protein expresion of Akt/PKB and p-Akt/PKB (Ser 473) in KV and GK respectively. Conclusions KV and GK supplementation led to significant increases in the expressions of survival proteins. It is noteworthy that both KV and GK supplementation offered cardioprotection in ischaemic/reperfusion injury rat heart model. In all, GK showed better cardioprotective effect that KV.

scholarly journals Evaluation of antispermatogenic effect of Garcinia kola seed extract in Albino rats

2013 ◽  
Vol 2 (1) ◽  
pp. 15-18 ◽  
Author(s):  
AH Abu ◽  
PO Amuta ◽  
E Buba ◽  
TR Inusa
Keyword(s):  
Seed Extract ◽  
Albino Rats ◽  
Garcinia Kola

The Effects of Methanolic Seed Extract of Garcinia kola on Some Specific and Non-Specific Immune Responses in Mice

2007 ◽  
Vol 3 (4) ◽  
pp. 347-351 ◽  
Author(s):  
C.S. Nworu . ◽  
P.A. Akah . ◽  
C.O. Okoli . ◽  
C.O. Esimone . ◽  
F.B.C. Okoye .
Keyword(s):  
Immune Responses ◽  
Seed Extract ◽  
Garcinia Kola

scholarly journals Evaluation of some metabolic activities and immuno-stimulatory potential of methanolic seed extract of Garcinia kola (Heckel) in female albino Wistar rats

2017 ◽  
Vol 11 (37) ◽  
pp. 470-474
Author(s):  
B. Bukar B. ◽  
W. Dayom D. ◽  
S. Okpeke O. ◽  
Ior L. ◽  
D. Falang K. ◽  
...  
Keyword(s):  
Wistar Rats ◽  
Seed Extract ◽  
Garcinia Kola ◽  
Metabolic Activities ◽  
Garcinia Kola Heckel

Phytochemical and <i>in vitro</i> antimicrobial properties of <i>n</i>-butanol seed extract of <i>Garcinia kola</i>

2013 ◽  
Vol 2 (1) ◽  
pp. 11
Author(s):  
Kyari Sanda ◽  
Mohammed Auwal ◽  
Falmata Sanda ◽  
Yagana Majama ◽  
Baba Gambo
Keyword(s):  
Antimicrobial Properties ◽  
Seed Extract ◽  
Garcinia Kola

scholarly journals Evaluation of Properties of Garcinia kola (Heckel) Seed Extract in Lipospheres Based on Fat from Capra hircus: An Antimicrobial Study.

2014 ◽  
Vol 4 (4) ◽  
pp. 1274-1280
Author(s):  
Chime Salome A . ◽  
Momoh M. A . ◽  
Onyishi V. I . ◽  
Abonyi A. C . ◽  
Onunkwo Godswill C . ◽  
...  
Keyword(s):  
Seed Extract ◽  
Capra Hircus ◽  
Garcinia Kola ◽  
Antimicrobial Study ◽  
Garcinia Kola Heckel

Anti-pyretic Activity of Garcinia kola Seed Extract

2014 ◽  
Vol 4 (5) ◽  
pp. 511-521 ◽  
Author(s):  
Kakjing Falang
Keyword(s):  
Seed Extract ◽  
Garcinia Kola
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