scholarly journals Comparison of myocardial reperfusion between intracoronary versus intravenous cangrelor administration in patients undergoing primary percutaneous coronary intervention

2021 ◽  
Author(s):  
Iacopo Muraca ◽  
Matteo Pennesi ◽  
Alessio Mattesini ◽  
Angela Migliorini ◽  
Nazario Carrabba ◽  
...  
Keyword(s):  
Percutaneous Coronary Intervention ◽  
Primary Percutaneous Coronary Intervention ◽  
Coronary Intervention ◽  
Myocardial Reperfusion ◽  
Percutaneous Coronary

P3591Residual atherothrombotic burden after primary percutaneous coronary intervention and myocardial reperfusion - An optical frequency domain imaging study

2019 ◽  
Vol 40 (Supplement_1) ◽  
Author(s):  
V Roule ◽  
L Schwob ◽  
A Lemaitre ◽  
M Bignon ◽  
P Ardouin ◽  
...  
Keyword(s):  
Percutaneous Coronary Intervention ◽  
Frequency Domain ◽  
Primary Percutaneous Coronary Intervention ◽  
Imaging Study ◽  
Coronary Intervention ◽  
Myocardial Reperfusion ◽  
Optical Frequency ◽  
Primary Pci ◽  
Optical Frequency Domain Imaging ◽  
Percutaneous Coronary

Abstract Background The clinical significance of residual in-stent atherothrombotic burden (ATB) after primary percutaneous coronary intervention (PCI) remains unclear. Several methods of ATB quantification using optical frequency domain imaging (OFDI) exist. Objectives We aimed to assess the relationship between residual ATB after primary PCI measured in OFDI using different methods and myocardial blush grade (MBG). Methods We prospectively included 60 ST-elevation myocardial infarction patients pre-treated with aspirin and ticagrelor. OFDI volumetric quantification using planimetry (with intervals every frame or every millimeter) and semi-quantitative score were used to determine ATB. Patients were divided into two groups according to final MBG 3 or <3. Results MBG 3 was identified in 28 (46%) patients. Altogether, 13318 OFDI cross-sections were analyzed. The mean ATB was 10.08±5.21%. ATB was lower in patients with normal final MBG compared to those with impaired MBG, regardless of the method used (8.15±5.58 vs 11.77±4.28%; p=0.007 for quantification per frame; 7.8±5.19 vs 11.07±4.07%; p=0.009 for quantification per mm and 11.21±11.75 vs 22.91±17.35; p=0.003 for the semi-quantitative thrombus score, respectively). Table 1. Post stenting OFDI findings OFDI measures All Final Blush <3 Final Blush 3 p n=60 (100%) n=32 (53%) n=28 (47%) Stent volume (mm3) 219.42±135.76 226.08±168.69 211.82±86.57 0.68 Evaluation per frame   Atherothrombotic volume (mm3) 21.66±16.81 25.83±18.86 16.89±12.83 0.035   Atherothrombotic burden (%) 10.08±5.21 11.77±4.28 8.15±5.58 0.007 Evaluation per millimeter   Atherothrombotic volume (mm3) 20.71±16.16 24.57±18.15 16.29±12.43 0.042   Atherothrombotic burden (%) 9.5±4.88 11.07±4.07 7.8±5.19 0.009 Thrombus score 17.45±16 22.91±17.35 11.21±11.75 0.003 Optical frequency domain imaging example Conclusion Residual post-stenting ATB remains substantial after primary PCI in STEMI patients, even when pre-treated with ticagrelor and aspirin. Mostly, it appears as an important surrogate of clinical outcome as patients with normal myocardial reperfusion presented lower residual ATB.

scholarly journals NT-proBNP: a marker for successful myocardial reperfusion in AMI patients treated with primary percutaneous coronary intervention

2004 ◽  
Vol 6 (6) ◽  
pp. 749-752 ◽  
Author(s):  
Jaap-Ronald Blom ◽  
Arnoud W.J. van ‘t Hof ◽  
Jose P.S. Henriques ◽  
J. Hans Geertman ◽  
Robbert Slingerland ◽  
...  
Keyword(s):  
Percutaneous Coronary Intervention ◽  
Primary Percutaneous Coronary Intervention ◽  
Coronary Intervention ◽  
Myocardial Reperfusion ◽  
Percutaneous Coronary

Residual platelet reactivity after pre-treatment with ticagrelor prior to primary percutaneous coronary intervention is associated with suboptimal myocardial reperfusion

2019 ◽  
pp. 204887261986021
Author(s):  
Vincent Roule ◽  
Thibaut Heudel ◽  
Adrien Lemaitre ◽  
Mathieu Bignon ◽  
Pierre Ardouin ◽  
...  
Keyword(s):  
Percutaneous Coronary Intervention ◽  
Primary Percutaneous Coronary Intervention ◽  
Platelet Reactivity ◽  
Point Of Care ◽  
Coronary Intervention ◽  
Myocardial Reperfusion ◽  
Primary Pci ◽  
P2y12 Inhibitors ◽  
Percutaneous Coronary ◽  
Pre Treatment

Background: The evidence of a clinical benefit of P2Y12 inhibitor pre-treatment in primary percutaneous coronary intervention (PCI) and the relation between the level of platelet inhibition and myocardial reperfusion with newer potent P2Y12 inhibitors remain unclear. We aimed to assess the relationship between platelet reactivity at the time of primary PCI after pre-treatment with aspirin and ticagrelor and the post-PCI myocardial blush grade (MBG). Methods: We prospectively included 61 patients. Platelet reaction units for ticagrelor (PRU) and aspirin reaction units (ARU) were measured using the point-of-care test VerifyNow before PCI. The high on-ticagrelor (PRU >208) and on-aspirin (ARU ⩾ 550) platelet reactivity (HPR and HaPR) were assessed. Patients were divided into two groups according to MBG 3 or <3. Results: MBG 3 was identified in 28 (46%) patients. Mean PRU was lower in such patients as compared with those with MBG <3 (155.82 ± 90.91 vs. 227.42 ± 65.18; p=0.001) while mean ARU was similar between groups. HPR and HaPR were observed in 30 (49.2%) and 11 patients (18%), respectively. HPR but not HaPR was more frequent in the group with impaired MBG (66.7 vs. 28.6%; p=0.003 and 21.2 vs. 14.3%; p=0.48 respectively). Conclusion: Our study shows that higher PRU and the subsequent HPR at the time of primary PCI, after pretreatment with ticagrelor, are the only correlates of post PCI MBG. These findings support the earliest possible loading with ticagrelor prior to primary PCI.

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