Premature closure of the fetal ductus arteriosus after maternal use of non‐steroidal anti‐inflammatory drugs

1998 ◽  
Vol 169 (5) ◽  
pp. 270-271 ◽  
Keyword(s):  
Ductus Arteriosus ◽  
Premature Closure ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

scholarly journals Critical Ebstein’s anomaly with circular shunt: from successful fetal therapy with non-steroidal anti-inflammatory drugs to biventricular repair using Da Silva cone technique

2021 ◽  
pp. 1-4
Author(s):  
Lilian M. Lopes ◽  
Rodrigo F. Bezerra ◽  
Jose Pedro da Silva ◽  
Luciana da Fonseca da Silva
Keyword(s):  
Single Ventricle ◽  
Ductus Arteriosus ◽  
Ebstein’S Anomaly ◽  
Biventricular Repair ◽  
Fetal Demise ◽  
Ebstein's Anomaly ◽  
Gestational Week ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Single Ventricle Palliation

Abstract We report an innovative treatment strategy for fetal Ebstein’s anomaly with a circular shunt. We used transplacental non-steroidal anti-inflammatory drugs, at the 29th gestational week, to constrict the ductus arteriosus avoiding fetal demise. We addressed the critical neonate with an urgent Starnes procedure. Finally, instead of following the usual single-ventricle palliation pathway after the Starnes procedure, we achieved successful two-ventricle repair with the cone technique at 5 month old.

Non-steroid anti-inflammatory drugs in the treatment of patent ductus arteriosus in European newborns

2009 ◽  
Vol 22 (sup3) ◽  
pp. 77-80 ◽  
Author(s):  
Hercília Guimarães ◽  
Gustavo Rocha ◽  
Teresa Tomé ◽  
Fani Anatolitou ◽  
Kosmas Sarafidis ◽  
...  
Keyword(s):  
Patent Ductus Arteriosus ◽  
Ductus Arteriosus ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Patent Ductus

scholarly journals Organ and prenatal toxicity of nonsteroidal anti-inflammatory drugs

2015 ◽  
Vol 28 (3) ◽  
pp. 200-203
Author(s):  
Katarzyna Dyndor ◽  
Wojciech Dworzanski ◽  
Małgorzata Pliszczynska-Steuden ◽  
Monika Cendrowska-Pinkosz ◽  
Tomasz Chroscicki ◽  
...  
Keyword(s):  
Ductus Arteriosus ◽  
Late Pregnancy ◽  
Congenital Defects ◽  
Abdominal Wall Defects ◽  
Cox Inhibitors ◽  
Prenatal Toxicity ◽  
Developing Heart ◽  
Increased Risk ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

Abstract Non-selective cyclooxygenase (COX) inhibitors, commonly referred to as nonsteroidal anti-inflammatory drugs (NSAIDs), are among the most taken pharmaceuticals. In adults, they can have a series of side effects, including especially gastroenterotoxicity, hepatotoxicity, nephrotoxicity, chondrotoxicity, and neurotoxicity, and they can induce allergic reactions. Any exacerbation of symptoms depends on the chemical structure of the drug, its dosage and duration of exposure, individual sensitivity, comorbidities and the degree of inhibition of basic COX isoenzymes - the constitutive (COX-2) and induced (COX-1) expressions. However, data on prenatal toxicity are inconsistent. Classic nonselective COX inhibitors do not result in an increase in the risk of developing significant congenital defects; however, if used in the late-pregnancy period, they can have an adverse effect on the foetus, by inducing the premature closure of the ductus arteriosus and by producing a tocolytic effect. Individual reports also indicate the increased risk of developing heart and anterior abdominal wall defects, as well as hypospadias.

Complete closure of the ductus arteriosus in the foetus with transposition of the great arteries

2020 ◽  
Vol 30 (4) ◽  
pp. 588-590
Author(s):  
Agnieszka Grzyb ◽  
Adam Koleśnik ◽  
Dariusz Gruszfeld ◽  
Joanna Szymkiewicz-Dangel
Keyword(s):  
Pulmonary Hypertension ◽  
Organ Failure ◽  
Ductus Arteriosus ◽  
Persistent Pulmonary Hypertension ◽  
Multi Organ Failure ◽  
Complete Closure ◽  
Other Substances ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

AbstractPrenatal restriction of the ductus arteriosus can manifest as persistent pulmonary hypertension in the newborn, especially dangerous with the transposition of the great arteries. Its aetiology has long been related to maternal intake of non-steroidal anti-inflammatory drugs; however, some other substances, including polyphenols, may have similar properties. We describe a case of complete prenatal closure of the ductus arteriosus in the foetus with transposition of the great arteries. The newborn presented with pulmonary hypertension unresponsive to pharmacotherapy and died of multi-organ failure.

scholarly journals Foetal ductus arteriosus constriction unrelated to non-steroidal anti-Inflammatory drugs: a case report and literature review

2021 ◽  
Vol 53 (1) ◽  
pp. 860-873
Author(s):  
Giovanna Battistoni ◽  
Ramona Montironi ◽  
Jacopo Di Giuseppe ◽  
Luca Giannella ◽  
Giovanni Delli Carpini ◽  
...  
Keyword(s):  
Case Report ◽  
Literature Review ◽  
Ductus Arteriosus ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

Renal safety of Non Steroidal Anti Inflammatory Drugs (NSAIDs) in the pharmacologic treatment of patent ductus arteriosus

2011 ◽  
Vol 24 (sup1) ◽  
pp. 50-52 ◽  
Author(s):  
Vassilios Fanos ◽  
Maria Antonietta Marcialis ◽  
Pier Paolo Bassareo ◽  
Roberto Antonucci ◽  
Marco Zaffanello ◽  
...  
Keyword(s):  
Patent Ductus Arteriosus ◽  
Ductus Arteriosus ◽  
Pharmacologic Treatment ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Renal Safety ◽  
Patent Ductus
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