Non‐invasive prenatal testing: clinical utility and ethical concerns about recent advances

2021 ◽  
Author(s):  
Joseph Thomas ◽  
James Harraway ◽  
David Kirchhoffer
Keyword(s):  
Clinical Utility ◽  
Prenatal Testing ◽  
Ethical Concerns ◽  
Non Invasive ◽  
Recent Advances

scholarly journals The Clinical Utility of Non-invasive Prenatal Testing for Pregnant Women With Different Diagnostic Indications

2020 ◽  
Vol 11 ◽  
Author(s):  
Jianli Zheng ◽  
Haiyan Lu ◽  
Min Li ◽  
Yongjuan Guan ◽  
Fangfang Yang ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Clinical Utility ◽  
Prenatal Testing ◽  
Non Invasive

Limited Clinical Utility of Non-invasive Prenatal Testing for Subchromosomal Abnormalities

2016 ◽  
Vol 71 (4) ◽  
pp. 211-213
Author(s):  
Kitty K. Lo ◽  
Evangelia Karampetsou ◽  
Christopher Boustred ◽  
Fiona McKay ◽  
Sarah Mason ◽  
...  
Keyword(s):  
Clinical Utility ◽  
Prenatal Testing ◽  
Non Invasive

scholarly journals Limited Clinical Utility of Non-invasive Prenatal Testing for Subchromosomal Abnormalities

2016 ◽  
Vol 98 (1) ◽  
pp. 34-44 ◽  
Author(s):  
Kitty K. Lo ◽  
Evangelia Karampetsou ◽  
Christopher Boustred ◽  
Fiona McKay ◽  
Sarah Mason ◽  
...  
Keyword(s):  
Clinical Utility ◽  
Prenatal Testing ◽  
Non Invasive

scholarly journals Reviewing Articles Related to Recent Advances in Non-invasive Prenatal Testing and Nursing Implications

2013 ◽  
Vol 19 (4) ◽  
pp. 675-683 ◽  
Author(s):  
Myunghee Jun ◽  
Gyeyoung Shin ◽  
Myung Haeng Hur ◽  
Kyung-Sook Choi
Keyword(s):  
Prenatal Testing ◽  
Non Invasive ◽  
Recent Advances

scholarly journals Assessment and clinical utility of a non-Next Generation Sequencing based Non-Invasive Prenatal Testing technology

2021 ◽  
Author(s):  
Uzay Gormus ◽  
Alka Chaubey ◽  
Suresh Shenoy ◽  
Yong Wee Wong ◽  
Lee Yin Chan ◽  
...  
Keyword(s):  
Clinical Utility ◽  
Prenatal Testing ◽  
Trisomy 13 ◽  
Rolling Circle Replication ◽  
Rolling Circle ◽  
Non Invasive ◽  
Clinical Laboratories ◽  
Testing Technology ◽  
The Cost ◽  
Fetal Aneuploidies

Background: Rolling circle replication (RCR) is a novel technology that has not been applied to cell-free DNA (cfDNA) testing until recently. Given the cost and simplicity advantages of this technology compared to other platforms currently used in cfDNA analysis, an assessment of RCR in clinical laboratories was performed. Here, we present the first validation study from clinical laboratories utilizing RCR technology. Methods: 831 samples from spontaneously pregnant women carrying a singleton fetus and 25 synthetic samples were analyzed for the fetal risk of Trisomy 21, Trisomy 18 and Trisomy 13 by three laboratories on three continents. All women who provided the samples were followed to birth, where evaluation for fetal aneuploidies was performed using newborn examinations and any suspected aneuploidies were confirmed with karyotyping. Results: The study found rolling circle replication to be a highly viable technology for clinical assessment of fetal aneuploidies with 100% sensitivity for T21 (95% CI:82.35% - 100.00%); 100.00% sensitivity for T18 (71.51% - 100.00%) and 100.00% sensitivity for T13 analyses (66.37% - 100.00%). The specificities were >99% for each trisomies [99.7% (99.01% - 99.97%) for T21; 99.5% (98.62% - 99.85%) for T18; 99.7% (99.03% - 99.97%) for T13], along with a first pass no-call rate of 0.93%. Conclusions: The study showed that using a rolling circle replication-based cfDNA system for the evaluation of the common aneuploidies would provide greater accuracy and clinical utility compared to conventional biochemical screening and comparable results to other reported cfDNA methodologies.

Clinical utility and cost of non-invasive prenatal testing

2013 ◽  
Vol 27 (3) ◽  
pp. 320-321 ◽  
Author(s):  
Howard Cuckle ◽  
Peter Benn ◽  
Eugene Pergament
Keyword(s):  
Clinical Utility ◽  
Prenatal Testing ◽  
Non Invasive
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