Determining the Clearance of Degraded Protein via a Monoclonal Antibody Purification Process in Support of Cleaning Carryover Limits in Multiproduct Facilities

2020 ◽  
Vol 74 (4) ◽  
pp. 377-393
Author(s):  
Pao Lin Che ◽  
Alison P. Bailey ◽  
Chi Yan J. Tam ◽  
Melissa Alvarez ◽  
Adeyma Y. Arroyo
Keyword(s):  
Monoclonal Antibody ◽  
Purification Process ◽  
Antibody Purification

Nature of foulants and fouling mechanism in the Protein A MabSelect resin cycled in a monoclonal antibody purification process

2015 ◽  
Vol 113 (1) ◽  
pp. 141-149 ◽  
Author(s):  
Shaojie Zhang ◽  
William Daniels ◽  
Jeffrey Salm ◽  
Judy Glynn ◽  
Joseph Martin ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Protein A ◽  
Purification Process ◽  
Antibody Purification ◽  
Fouling Mechanism

A safe, effective, and facility compatible cleaning in place procedure for affinity resin in large-scale monoclonal antibody purification

2013 ◽  
Vol 1308 ◽  
pp. 86-95 ◽  
Author(s):  
Lu Wang ◽  
Jill Dembecki ◽  
Neil E. Jaffe ◽  
Brian W. O’Mara ◽  
Hui Cai ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Large Scale ◽  
Antibody Purification ◽  
Affinity Resin
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