Mechanistic modeling of hydrophobic interaction chromatography for monoclonal antibody purification: process optimization in the quality by design paradigm

Lalita Kanwar Shekhawat; Monu Chandak; Anurag S Rathore

doi:10.1002/jctb.5324

Mechanistic modeling of hydrophobic interaction chromatography for monoclonal antibody purification: process optimization in the quality by design paradigm

Journal of Chemical Technology & Biotechnology ◽

10.1002/jctb.5324 ◽

2017 ◽

Vol 92 (10) ◽

pp. 2527-2537 ◽

Cited By ~ 5

Author(s):

Lalita Kanwar Shekhawat ◽

Monu Chandak ◽

Anurag S Rathore

Keyword(s):

Monoclonal Antibody ◽

Process Optimization ◽

Hydrophobic Interaction ◽

Quality By Design ◽

Hydrophobic Interaction Chromatography ◽

Mechanistic Modeling ◽

Purification Process ◽

Antibody Purification ◽

Design Paradigm

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Mechanistic modeling of hydrophobic interaction chromatography for monoclonal antibody purification: process optimization in the quality by design paradigm

Journal of Chemical Technology & Biotechnology ◽

10.1002/jctb.5742 ◽

2018 ◽

Vol 93 (9) ◽

pp. 2784-2784 ◽

Cited By ~ 1

Author(s):

Lalita Kanwar Shekhawat ◽

Monu Chandak ◽

Anurag S Rathore

Keyword(s):

Monoclonal Antibody ◽

Process Optimization ◽

Hydrophobic Interaction ◽

Quality By Design ◽

Hydrophobic Interaction Chromatography ◽

Mechanistic Modeling ◽

Purification Process ◽

Antibody Purification ◽

Design Paradigm

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Comparison of standard and new generation hydrophobic interaction chromatography resins in the monoclonal antibody purification process

Journal of Chromatography A ◽

10.1016/j.chroma.2007.07.083 ◽

2008 ◽

Vol 1177 (2) ◽

pp. 272-281 ◽

Cited By ~ 74

Author(s):

Jie Chen ◽

Jenifer Tetrault ◽

Arthur Ley

Keyword(s):

Monoclonal Antibody ◽

Hydrophobic Interaction ◽

Hydrophobic Interaction Chromatography ◽

Purification Process ◽

Antibody Purification ◽

New Generation

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Native Hydrophobic Interaction Chromatography Hyphenated to Mass Spectrometry for Characterization of Monoclonal Antibody Minor Variants

Analytical Chemistry ◽

10.1021/acs.analchem.9b04467 ◽

2019 ◽

Vol 91 (24) ◽

pp. 15360-15364 ◽

Cited By ~ 10

Author(s):

Bingchuan Wei ◽

Guanghui Han ◽

Jia Tang ◽

Wendy Sandoval ◽

Yonghua Taylor Zhang

Keyword(s):

Mass Spectrometry ◽

Monoclonal Antibody ◽

Hydrophobic Interaction ◽

Hydrophobic Interaction Chromatography

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Defining process design space for a hydrophobic interaction chromatography (HIC) purification step: Application of quality by design (QbD) principles

Biotechnology and Bioengineering ◽

10.1002/bit.22894 ◽

2010 ◽

Vol 107 (6) ◽

pp. 985-997 ◽

Cited By ~ 51

Author(s):

Canping Jiang ◽

Lisa Flansburg ◽

Sanchayita Ghose ◽

Paul Jorjorian ◽

Abhinav A. Shukla

Keyword(s):

Hydrophobic Interaction ◽

Process Design ◽

Quality By Design ◽

Design Space ◽

Hydrophobic Interaction Chromatography ◽

Purification Step

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PROCESS DEVELOPMENT FOR ROBUST REMOVAL OF AGGREGATES USING CATION EXCHANGE CHROMATOGRAPHY IN MONOCLONAL ANTIBODY PURIFICATION WITH IMPLEMENTATION OF QUALITY BY DESIGN

Preparative Biochemistry & Biotechnology ◽

10.1080/10826068.2012.654572 ◽

2012 ◽

Vol 42 (2) ◽

pp. 183-202 ◽

Cited By ~ 19

Author(s):

Zhihao Xu ◽

Jason Li ◽

Joe X. Zhou

Keyword(s):

Monoclonal Antibody ◽

Cation Exchange ◽

Quality By Design ◽

Process Development ◽

Exchange Chromatography ◽

Cation Exchange Chromatography ◽

Antibody Purification

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Water on hydrophobic surfaces: Mechanistic modeling of hydrophobic interaction chromatography

Journal of Chromatography A ◽

10.1016/j.chroma.2016.07.085 ◽

2016 ◽

Vol 1465 ◽

pp. 71-78 ◽

Cited By ~ 13

Author(s):

Gang Wang ◽

Tobias Hahn ◽

Jürgen Hubbuch

Keyword(s):

Hydrophobic Interaction ◽

Hydrophobic Interaction Chromatography ◽

Mechanistic Modeling ◽

Hydrophobic Surfaces

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Recent Advancement in Application of Hydrophobic Interaction Chromatography for Aggregate Removal in Industrial Purification Process

Current Pharmaceutical Biotechnology ◽

10.2174/138920109788488897 ◽

2009 ◽

Vol 10 (4) ◽

pp. 427-433 ◽

Cited By ~ 36

Author(s):

Yuefeng Lu ◽

Brian Williamson ◽

Ronald Gillespie

Keyword(s):

Hydrophobic Interaction ◽

Hydrophobic Interaction Chromatography ◽

Purification Process ◽

Recent Advancement

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Paper-PEG-based membranes for hydrophobic interaction chromatography: Purification of monoclonal antibody

Biotechnology and Bioengineering ◽

10.1002/bit.21680 ◽

2008 ◽

Vol 99 (6) ◽

pp. 1434-1442 ◽

Cited By ~ 21

Author(s):

Deqiang Yu ◽

Xiaonong Chen ◽

Robert Pelton ◽

Raja Ghosh

Keyword(s):

Monoclonal Antibody ◽

Hydrophobic Interaction ◽

Hydrophobic Interaction Chromatography

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Characterization of recombinant monoclonal antibody variants detected by hydrophobic interaction chromatography and imaged capillary isoelectric focusing electrophoresis

Journal of Chromatography B ◽

10.1016/j.jchromb.2018.03.049 ◽

2018 ◽

Vol 1085 ◽

pp. 96-103 ◽

Cited By ~ 11

Author(s):

Cory King ◽

Rekha Patel ◽

Gomathinayagam Ponniah ◽

Christine Nowak ◽

Alyssa Neill ◽

...

Keyword(s):

Monoclonal Antibody ◽

Isoelectric Focusing ◽

Hydrophobic Interaction ◽

Hydrophobic Interaction Chromatography ◽

Capillary Isoelectric Focusing ◽

Recombinant Monoclonal Antibody

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Analytical characterization of a monoclonal antibody therapeutic reveals a three-light chain species that is efficiently removed using hydrophobic interaction chromatography

mAbs ◽

10.4161/mabs.26192 ◽

2013 ◽

Vol 5 (6) ◽

pp. 925-935 ◽

Cited By ~ 10

Author(s):

Rachel B Wollacott ◽

Paul L Casaz ◽

Trevor J Morin ◽

H Lily Zhu ◽

Roger S Anderson ◽

...

Keyword(s):

Monoclonal Antibody ◽

Light Chain ◽

Hydrophobic Interaction ◽

Hydrophobic Interaction Chromatography ◽

Analytical Characterization

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