scholarly journals Genetic and Epigenetic Factors Affecting Cytochrome P450 Phenotype and Their Clinical Relevance

10.5772/36451 ◽  
2012 ◽  
Author(s):  
Viola Tamsi ◽  
Andrs Falus
Keyword(s):  
Cytochrome P450 ◽  
Clinical Relevance ◽  
Epigenetic Factors ◽  
Factors Affecting

Genotypes of cytochrome P450 and clinical response to clomipramine in patients with major depression

1995 ◽  
Vol 10 (8) ◽  
pp. 410-412 ◽  
Author(s):  
J Bouchez ◽  
V Dumur ◽  
M Lhermitte ◽  
M Goudemand
Keyword(s):  
Cytochrome P450 ◽  
Major Depression ◽  
Clinical Relevance ◽  
Tricyclic Antidepressant ◽  
Interindividual Variation ◽  
Individual Response ◽  
Poor Metaboliser ◽  
Factors Affecting ◽  
Hospitalised Patients ◽  
The Individual

SummaryThe genetic cytochrome P450 polymorphism is reported in factors affecting the individual response to drugs. The interindividual variation at steady-state levels or also in elimination of drugs, finds an explanation in genetic differences in the metabolism. In particular, activities of the P450-IID6 isoenzyme are related to the sparteine/debrisoquine oxidation polymorphism. Phenotyping such a system has been proposed to analyse variability in the tricyclic antidepressant level. To analyse clinical relevance of a pharmacogenetic approach, we studied the cytochrome P450 CYP2D6 genotypes and the clinical responses to clomipramine in 21 hospitalised patients who met DSM-III-R criteria for major depression. Three patients were predicted as poor metabolizers. We suggested a limitation of clomipramine (CMI) hydroxylation in poor metaboliser (PM) patients which is balanced by a desmethylation. The clinical efficacy pattern does not differ in poor metaboliser and early metaboliser patients. Firstly, there is no significant differences in the evolution of scores on MADRS and specific retardation scale into the two groups. Secondly, outcome of side effects does not occur more frequently in PM patients. Clinical relevance of such an approach needs further study.

The Role of Cytochrome P450 Enzymes in the Metabolism of Risperidone and Its Clinical Relevance for Drug Interactions

2004 ◽  
Vol 5 (6) ◽  
pp. 573-579 ◽  
Author(s):  
R. Berecz ◽  
P. Dorado ◽  
A. Rubia ◽  
M. Caceres ◽  
I. Degrell ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Drug Interactions ◽  
Clinical Relevance ◽  
Cytochrome P450 Enzymes

Cytochrome P450 2B6: function, genetics, and clinical relevance

2012 ◽  
Vol 27 (4) ◽  
Author(s):  
Miia Turpeinen ◽  
Ulrich M. Zanger
Keyword(s):  
Cytochrome P450 ◽  
Clinical Relevance ◽  
Cytochrome P450 2B6

Factors Affecting the Detection and Treatment of Occlusal Caries Using the International Caries Detection and Assessment System

2011 ◽  
Vol 36 (6) ◽  
pp. 597-607 ◽  
Author(s):  
AA Al-Khatrash ◽  
YM Badran ◽  
QD Alomari
Keyword(s):  
Dental Caries ◽  
Clinical Relevance ◽  
Assessment System ◽  
Caries Detection ◽  
Occlusal Caries ◽  
Factors Affecting ◽  
The World ◽  
Predominant Form ◽  
Dental Schools

Clinical Relevance Occlusal caries is the predominant form of dental caries at the present time. This study documents the variability in detection and treatment of occlusal caries among dentists graduating from different dental schools around the world and practicing in Kuwait. Furthermore, it shows that dentists tend to overtreat occlusal caries.

scholarly journals Review article: the prevalence and clinical relevance of cytochrome P450 polymorphisms

2007 ◽  
Vol 26 ◽  
pp. 211-219 ◽  
Author(s):  
P. A. H. M. WIJNEN ◽  
R. A. M. OP DEN BUIJSCH ◽  
M. DRENT ◽  
P. M. J. C. KUIPERS ◽  
C. NEEF ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Clinical Relevance ◽  
Review Article
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