scholarly journals A Novel FECH Mutation Causes Erythropoietic Protoporphyria with Severe Liver Dysfunction

2018 ◽  
Vol In Press (In Press) ◽  
Author(s):  
Fang Xu ◽  
Xiaomei Wang ◽  
Xiumei Chi ◽  
Xiuting He ◽  
Yue Qi ◽  
...  
Keyword(s):  
Liver Dysfunction ◽  
Severe Liver ◽  
Erythropoietic Protoporphyria ◽  
Severe Liver Dysfunction

Erythropoietic protoporphyria with severe liver dysfunction and acute pancreatitis

2000 ◽  
Vol 35 (5) ◽  
pp. 391-395 ◽  
Author(s):  
Koga Komatsu ◽  
Tooru Shimosegawa ◽  
Midori Uchi ◽  
Yoshisuke Maruhama ◽  
Takayoshi Toyota
Keyword(s):  
Acute Pancreatitis ◽  
Liver Dysfunction ◽  
Severe Liver ◽  
Erythropoietic Protoporphyria ◽  
Severe Liver Dysfunction

scholarly journals Severe liver dysfunction complicating course of COVID-19 in the critically ill: multifactorial cause or direct viral effect?

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Kevin Roedl ◽  
Dominik Jarczak ◽  
Andreas Drolz ◽  
Dominic Wichmann ◽  
Olaf Boenisch ◽  
...  
Keyword(s):  
Critically Ill ◽  
Liver Dysfunction ◽  
Critically Ill Patients ◽  
Severity Of Illness ◽  
University Hospital ◽  
Severe Liver ◽  
Saps Ii ◽  
Severe Liver Dysfunction ◽  
Global Threat ◽  
The University

Abstract Background SARS-CoV-2 caused a pandemic and global threat for human health. Presence of liver injury was commonly reported in patients with coronavirus disease 2019 (COVID-19). However, reports on severe liver dysfunction (SLD) in critically ill with COVID-19 are lacking. We evaluated the occurrence, clinical characteristics and outcome of SLD in critically ill patients with COVID-19. Methods Clinical course and laboratory was analyzed from all patients with confirmed COVID-19 admitted to ICU of the university hospital. SLD was defined as: bilirubin ≥ 2 mg/dl or elevation of aminotransferase levels (> 20-fold ULN). Results 72 critically ill patients were identified, 22 (31%) patients developed SLD. Presenting characteristics including age, gender, comorbidities as well as clinical presentation regarding COVID-19 overlapped substantially in both groups. Patients with SLD had more severe respiratory failure (paO2/FiO2: 82 (58–114) vs. 117 (83–155); p < 0.05). Thus, required more frequently mechanical ventilation (95% vs. 64%; p < 0.01), rescue therapies (ECMO) (27% vs. 12%; p = 0.106), vasopressor (95% vs. 72%; p < 0.05) and renal replacement therapy (86% vs. 30%; p < 0.001). Severity of illness was significantly higher (SAPS II: 48 (39–52) vs. 40 (32–45); p < 0.01). Patients with SLD and without presented viremic during ICU stay in 68% and 34%, respectively (p = 0.002). Occurrence of SLD was independently associated with presence of viremia [OR 6.359; 95% CI 1.336–30.253; p < 0.05] and severity of illness (SAPS II) [OR 1.078; 95% CI 1.004–1.157; p < 0.05]. Mortality was high in patients with SLD compared to other patients (68% vs. 16%, p < 0.001). After adjustment for confounders, SLD was independently associated with mortality [HR3.347; 95% CI 1.401–7.999; p < 0.01]. Conclusion One-third of critically ill patients with COVID-19 suffer from SLD, which is associated with high mortality. Occurrence of viremia and severity of illness seem to contribute to occurrence of SLD and underline the multifactorial cause.

Purine Analogs for Patients with Non-Hodgkin Lymphoma and Severe Liver Dysfunction

2018 ◽  
Vol 18 ◽  
pp. S291-S292
Author(s):  
Tamer Khashab ◽  
Ashley Manganiello ◽  
Julianne Hibbs ◽  
Thomas Oliver ◽  
Jonathan Doroshow ◽  
...  
Keyword(s):  
Hodgkin Lymphoma ◽  
Liver Dysfunction ◽  
Severe Liver ◽  
Non Hodgkin Lymphoma ◽  
Purine Analogs ◽  
Severe Liver Dysfunction

Severe liver dysfunction in patients withMycoplasma pneumoniaeinfection

2010 ◽  
Vol 52 (2) ◽  
pp. e105-e107 ◽  
Author(s):  
Akitoshi Murayama ◽  
Daiki Abukawa ◽  
Keiko Watanabe ◽  
Hiroaki Umebayashi ◽  
Tetsuji Inagaki ◽  
...  
Keyword(s):  
Liver Dysfunction ◽  
Severe Liver ◽  
Severe Liver Dysfunction

scholarly journals Anorexia Nervosa with Severe Liver Dysfunction and Subsequent Critical Complications.

1999 ◽  
Vol 38 (7) ◽  
pp. 575-579 ◽  
Author(s):  
Sachiyo FURUTA ◽  
Yukako OZAWA ◽  
Kiyoshi MAEJIMA ◽  
Hirokazu TASHIRO ◽  
Tetsuji KITAHORA ◽  
...  
Keyword(s):  
Anorexia Nervosa ◽  
Liver Dysfunction ◽  
Severe Liver ◽  
Severe Liver Dysfunction

scholarly journals An evaluation of the usefulness of extracorporeal liver support techniques in patients with severe liver dysfunction

2019 ◽  
Vol 15 (1) ◽  
pp. 99-112 ◽  
Author(s):  
Mariusz Piechota ◽  
Anna Piechota ◽  
Małgorzata Misztal ◽  
Szymon Bernas ◽  
Iwona Pietraszek-Grzywaczewska
Keyword(s):  
Liver Dysfunction ◽  
Severe Liver ◽  
Liver Support ◽  
Extracorporeal Liver Support ◽  
Severe Liver Dysfunction
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